Ccl3 - chemokine (C-C motif) ligand 3 Gene

Also Known as Mip1a; Scya3; G0S19-1; MIP1-(a); LD78alpha; MIP-1alpha; MIP1-alpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20302

Summary

Enables chemokine activity. Involved in several processes, including astrocyte cell migration; macrophage chemotaxis; and positive regulation of macromolecule metabolic process. Located in extracellular space. Is expressed in articular cartilage; cartilage; knee joint; lung; and radius. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease. Orthologous to several human genes including CCL3 (C-C motif chemokine ligand 3). [provided by Alliance of Genome Resources, Apr 2022]

Ccl3 Products (1)

mRNA Protein Name
NM_011337.2 NP_035467.1 C-C motif chemokine 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chemokine activity IDA
IDA: Inferred from direct assay
7594543 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7594543 MGI
Biological Process GO Annotation Evidence References Source
involved in astrocyte cell migration IDA
IDA: Inferred from direct assay
15155903 MGI
involved in macrophage chemotaxis IGI
IGI: Inferred from genetic interaction
21784977 MGI
involved in positive regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
21784977 MGI
involved in positive regulation of interleukin-1 beta production IGI
IGI: Inferred from genetic interaction
21784977 MGI
involved in positive regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
15155903 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15155903 MGI
involved in positive regulation of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
21784977 MGI
involved in regulation of cell shape IDA
IDA: Inferred from direct assay
15155903 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
19139201 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-C motif chemokine 3

  • L2G25B

  • MIP-1-alpha

  • MIP1 (a)

  • SIS-alpha

  • TY-5

  • heparin-binding chemotaxis protein

  • macrophage inflammatory protein 1-alpha

  • macrophage inflammatory protein-1alpha

  • small-inducible cytokine A3

Recombinant Ccl3 Proteins

Cat. No. Product Name Accession Purity
HY-P7255 MIP-1 alpha/CCL3 Protein, Mouse (HEK293) P10855 (A24-A92) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7768 MIP-1 alpha/CCL3 Protein, Mouse (His) P10855/Q5SVU3 (A24-A92) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7768AF Animal-Free MIP-1 alpha/CCL3 Protein, Mouse (His) P10855 (A24-A92) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-B0498 Bindarit Inhibitor 99.59% Phase 3
HY-152846 Flizasertib Inhibitor 99.9% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149202 UT-11 Inhibitor 98.25% Unkown
HY-RS02099 CCL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-147660 IMMH001 Agonist 98.10% Unkown
HY-RS02100 CCL3L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120406 PLS-123 / Unkown
HY-124668 CCR1 antagonist 12 Antagonist / Unkown
HY-RS02101 CCL3L3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W505771 Seselin Inhibitor 99.55% Unkown
HY-174753 Human CCL3L1 mRNA / Unkown
HY-RS16642 Ccl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23076 Ccl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccl3 NCBI NCBI:6348