Sod1 - superoxide dismutase 1, soluble Gene

Also Known as Ipo1; SODC; Ipo-1; Sod-1; CuZnSOD; Cu/Zn-SOD; B430204E11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20655

Summary

Enables superoxide dismutase activity. Involved in axonal transport; negative regulation of inflammatory response; and positive regulation of phagocytosis. Acts upstream of or within several processes, including hydrogen peroxide biosynthetic process; muscle cell cellular homeostasis; and neurogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study amyotrophic lateral sclerosis type 1; dry eye syndrome; and low tension glaucoma. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sod1 Products (1)

mRNA Protein Name
NM_011434.2 NP_035564.1 superoxide dismutase [Cu-Zn]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
2960971 MGI
enables superoxide dismutase activity IDA
IDA: Inferred from direct assay
291939 MGI
enables superoxide dismutase activity IMP
IMP: Inferred from mutant phenotype
8673102 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within action potential initiation IMP
IMP: Inferred from mutant phenotype
30952836 MGI
involved in anterograde axonal transport IMP
IMP: Inferred from mutant phenotype
20510358 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
16036348 MGI
acts upstream of or within auditory receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
10464373 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
16377630 MGI
acts upstream of ectopic germ cell programmed cell death IMP
IMP: Inferred from mutant phenotype
16036348 MGI
acts upstream of or within embryo implantation IMP
IMP: Inferred from mutant phenotype
9516486 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
30952836 MGI
acts upstream of or within glutathione metabolic process IMP
IMP: Inferred from mutant phenotype
16377630 MGI
acts upstream of or within heart contraction IMP
IMP: Inferred from mutant phenotype
10679476 MGI
acts upstream of or within hydrogen peroxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
14679182 MGI
acts upstream of or within intracellular iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
16377630 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
10433959 MGI
acts upstream of or within muscle cell cellular homeostasis IMP
IMP: Inferred from mutant phenotype
16716900 MGI
acts upstream of or within myeloid cell homeostasis IGI
IGI: Inferred from genetic interaction
11493445 MGI
acts upstream of or within myeloid cell homeostasis IMP
IMP: Inferred from mutant phenotype
11493445 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
12223545 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16036348 MGI
acts upstream of or within negative regulation of developmental process IMP
IMP: Inferred from mutant phenotype
16036348 MGI
involved in negative regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
25381879 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
10464373 MGI
acts upstream of or within negative regulation of reproductive process IMP
IMP: Inferred from mutant phenotype
16036348 MGI
acts upstream of or within neurofilament cytoskeleton organization IGI
IGI: Inferred from genetic interaction
11343650 MGI
acts upstream of or within neurofilament cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
11343650 MGI
acts upstream of or within neuronal action potential IMP
IMP: Inferred from mutant phenotype
30952836 MGI
acts upstream of or within ovarian follicle development IMP
IMP: Inferred from mutant phenotype
9724058 MGI
acts upstream of or within peripheral nervous system myelin maintenance IMP
IMP: Inferred from mutant phenotype
10433959 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
12223545 MGI
involved in positive regulation of phagocytosis IGI
IGI: Inferred from genetic interaction
25381879 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
12433839 MGI
acts upstream of or within regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
16377630 MGI
acts upstream of or within relaxation of vascular associated smooth muscle IMP
IMP: Inferred from mutant phenotype
12433839 MGI
acts upstream of or within removal of superoxide radicals IGI
IGI: Inferred from genetic interaction
11493445 MGI
acts upstream of or within removal of superoxide radicals IMP
IMP: Inferred from mutant phenotype
8673102 MGI
acts upstream of or within response to axon injury IMP
IMP: Inferred from mutant phenotype
8673102 MGI
acts upstream of or within response to ethanol IMP
IMP: Inferred from mutant phenotype
17448893 MGI
acts upstream of or within response to heat IMP
IMP: Inferred from mutant phenotype
16942767 MGI
acts upstream of or within response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
15642323 MGI
acts upstream of or within response to oxidative stress IDA
IDA: Inferred from direct assay
12223545 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
16716900 MGI
acts upstream of or within response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
17059387 MGI
acts upstream of or within response to superoxide IMP
IMP: Inferred from mutant phenotype
9516486 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
16831125 MGI
acts upstream of or within retina homeostasis IMP
IMP: Inferred from mutant phenotype
16844785 MGI
involved in retrograde axonal transport IMP
IMP: Inferred from mutant phenotype
20510358 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
10436316 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
16036348 MGI
acts upstream of or within superoxide anion generation IDA
IDA: Inferred from direct assay
15317809 MGI
acts upstream of or within superoxide metabolic process IMP
IMP: Inferred from mutant phenotype
11404260 MGI
acts upstream of or within transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
10433959 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
15634772 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

superoxide dismutase [Cu-Zn]

  • Cu(2+)-Zn2+ superoxide dismutase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132580 Tofersen Inhibitor 96.53% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16074 ATN-224 98.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W115718 Cuprizone 99.61% Unkown
HY-115445 LCS-1 99.81% Unkown
HY-132580A Tofersen sodium Inhibitor 97.55% Unkown
HY-153019 NUCC-0000323 Inhibitor 99.86% Unkown
HY-173025 Nurr1 agonist 12 Agonist 99.62% Unkown
HY-148901 CMB-087229 Inhibitor 98.05% Unkown
HY-E70377 Cu/Zn Superoxide dismutase / Unkown
HY-123982 SOD1-Derlin-1 inhibitor-2 Inhibitor 99.86% Unkown
HY-138131 SOD1-Derlin-1 inhibitor-1 Inhibitor 99.93% Unkown
HY-RS13559 SOD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W073128 Perfluorotetradecanoic acid 98.0% Unkown
HY-145294 ROCK2-IN-5 Inhibitor / Unkown
HY-163772 Fraxinellone analog 1 Activator / Unkown
HY-172152 MP-010 / Unkown
HY-176827 SOD1-IN-1 Inhibitor / Unkown
HY-179533 SOD1-aggregation-IN-1 Inhibitor / Unkown
HY-182304 CLR01 sodium Inhibitor / Unkown
HY-182446 SRI-22818 Activator / Unkown
HY-182648 K811 Inhibitor / Unkown
HY-184165 F2F-202 Inhibitor / Unkown
HY-P10627 SOD1 (147-153) human / Unkown
HY-132580S Tofersen-d27 Inhibitor / Unkown
HY-161612 Mycosporine 2 glycine Inhibitor / Unkown
HY-183933 K812 Inhibitor / Unkown
HY-RS16926 Sod1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23369 Sod1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sod1 NCBI NCBI:6647