Stat2 - signal transducer and activator of transcription 2 Gene

Also Known as 1600010G07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20847

Summary

Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and ubiquitin-like protein Ligase binding activity. Involved in negative regulation of type I interferon-mediated signaling pathway and type I interferon signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in Zika fever; immunodeficiency 44; and neutropenia. Orthologous to human STAT2 (signal transducer and activator of transcription 2). [provided by Alliance of Genome Resources, Apr 2022]

Stat2 Products (1)

mRNA Protein Name
NM_019963.2 NP_064347.1 signal transducer and activator of transcription 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18234692 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
28165510 MGI
involved in type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
24598055 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12634107 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12634107 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

signal transducer and activator of transcription 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W722277A LCC-12 formate Inhibitor 99.90% Unkown
HY-169853 M351-0056 99.48% Unkown
HY-172946 SD-2301 Degrader / Unkown
HY-RS13887 STAT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17307 Stat2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23762 Stat2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-150895 SI-191 Ligand / Unkown
HY-172907 SMU-1k Inhibitor / Unkown
HY-174428 PROTAC JAK2 degrader-1 / Unkown
HY-178936 JAK2-IN-15 Inhibitor / Unkown
HY-184119 Pabgraminone C / Unkown
HY-174665 Human IFNAR2 mRNA / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99666 Interferon alfa-2b Agonist ≥95.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stat2 NCBI NCBI:6773