Prmt7 - protein arginine N-methyltransferase 7 Gene

Also Known as 4933402B05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 214572

About Prmt7

Chromosome 8: 106,937,568-106,979,426 forward strand.GRCm39:CM001001.3

This gene has 7 transcripts (splice variants), 206 orthologues, 7 paralogues and is associated with 47 phenotypes. Ubiquitous expression in testis adult (RPKM 37.9), ovary adult (RPKM 19.4) and 28 other tissues.

Summary

Enables Histone Methyltransferase activity (H4-R3 specific) and protein-arginine omega-N symmetric methyltransferase activity. Involved in DNA methylation involved in gamete generation; histone arginine methylation; and regulation of gene expression by genetic imprinting. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Is expressed in several structures, including brain and retina nuclear layer. Orthologous to human PRMT7 (protein arginine methyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]

Prmt7 Products (1)

mRNA Protein Name
NM_145404.1 NP_663379.1 protein arginine N-methyltransferase 7

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables histone H4R3 methyltransferase activity IDA
IDA: Inferred from direct assay
17048991 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17048991 MGI
enables protein-arginine omega-N symmetric methyltransferase activity IDA
IDA: Inferred from direct assay
17048991 MGI
Biological Process GO Annotation Evidence References Source
involved in genomic imprinting IDA
IDA: Inferred from direct assay
17048991 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prmt7 Protein Structure

COG4076

COG4076: cl44002 (36 - 185)

  • 0
  • 200
  • 400
  • 600
  • 692 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 7

  • [Myelin basic protein]-arginine N-methyltransferase PRMT7

  • histone-arginine N-methyltransferase PRMT7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112445 SGC3027 Inhibitor 98.06% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-124131 DS-437 Inhibitor 99.22% Unkown
HY-114211 SGC8158 Inhibitor 97.6% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-175821 PRMT1-IN-3 Inhibitor / Unkown
HY-111367 MS2734 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prmt7 NCBI NCBI:54496