Git1 - GIT ArfGAP 1 Gene

Also Known as Cat-1; p95Cat

Species: Mus musculus

Gene Type: protein coding
Gene ID: 216963

Summary

Predicted to enable several functions, including GTPase activator activity; gamma-tubulin binding activity; and small GTPase binding activity. Predicted to be a structural constituent of postsynaptic specialization. Involved in several processes, including cell redox homeostasis; modulation of chemical synaptic transmission; and nervous system development. Acts upstream of or within Ephrin Receptor signaling pathway. Located in calyx of Held and postsynapse. Is expressed in embryo. Used to study attention deficit hyperactivity disorder. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human GIT1 (GIT ArfGAP 1). [provided by Alliance of Genome Resources, Apr 2022]

Git1 Products (2)

mRNA Protein Name
NM_001004144.1 NP_001004144.1 ARF GTPase-activating protein GIT1 isoform 1
NM_001374758.1 NP_001361687.1 ARF GTPase-activating protein GIT1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10428811 MGI
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17310244 MGI
Biological Process GO Annotation Evidence References Source
involved in brain development IMP
IMP: Inferred from mutant phenotype
25792865 MGI
involved in cell redox homeostasis IMP
IMP: Inferred from mutant phenotype
32460388 MGI
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
32460388 MGI
acts upstream of or within ephrin receptor signaling pathway IDA
IDA: Inferred from direct assay
17310244 MGI
involved in intramembranous ossification IMP
IMP: Inferred from mutant phenotype
32460388 MGI
involved in locomotory behavior IMP
IMP: Inferred from mutant phenotype
25792865 MGI
involved in motor learning IMP
IMP: Inferred from mutant phenotype
25792865 MGI
involved in negative regulation of glycolytic process IMP
IMP: Inferred from mutant phenotype
32460388 MGI
involved in negative regulation of inflammatory response to wounding IMP
IMP: Inferred from mutant phenotype
32460388 MGI
involved in negative regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
32460388 MGI
involved in neuron development IMP
IMP: Inferred from mutant phenotype
25792865 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
26637799 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
26637799 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
26637799 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
26637799 MGI
Cellular Component GO Annotation Evidence References Source
is active in calyx of Held IDA
IDA: Inferred from direct assay
26637799 MGI
is active in calyx of Held IMP
IMP: Inferred from mutant phenotype
26637799 MGI
located in postsynapse IDA
IDA: Inferred from direct assay
24297929 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
26637799 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ARF GTPase-activating protein GIT1

  • ARF GAP GIT1

  • G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

  • G protein-coupled receptor kinase-interactor 1

  • GRK-interacting protein 1

Git1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Git1 Q68FF6 Arhgef7 Mus musculus Q9ES28
Anti Bait CoIP
16959763
Intra
Git1 Q68FF6 Arhgef7 Mus musculus Q9ES28
Anti Bait CoIP
19022416
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-152095 PPI-GIT1/β-Pix PPI-IN-1 Inhibitor 99.01% Unkown
HY-181978 GIT1-IN-1 / Unkown
HY-RS05438 GIT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19605 Git1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26101 Git1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Git1 NCBI NCBI:28964