Ttr - transthyretin Gene

Also Known as prealbumin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22139

About Ttr

Chromosome 18: 20,798,337-20,807,378 forward strand.GRCm39:CM001011.3

This gene has 1 transcript (splice variant), 178 orthologues, 2 paralogues and is associated with 10 phenotypes. Biased expression in liver adult (RPKM 3655.3), liver E18 (RPKM 293.2) and 7 other tissues.

Summary

This gene encodes a carrier protein responsible for the transport of thyroid Hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease. [provided by RefSeq, Mar 2010]

Ttr Products (1)

mRNA Protein Name
NM_013697.5 NP_038725.1 transthyretin precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23105095 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ttr Protein Structure

TR_THY

TR_THY: smart00095 (26 - 146)

  • 0
  • 100
  • 147 a.a.
Protein Preferred Names Protein Names

transthyretin

Recombinant Ttr Proteins

Cat. No. Product Name Accession Purity
HY-P73580 Transthyretin/TTR Protein, Mouse (HEK293, His) P07309 (G21-N147) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132609 Patisiran sodium 99.09% Unkown
HY-14852 Tafamidis Inhibitor 99.93% Yes
HY-132608 Inotersen sodium 96.44% Unkown
HY-132589A Vutrisiran sodium Inhibitor 97.37% Unkown
HY-14852A Tafamidis meglumine 99.95% Yes
HY-148089A Eplontersen sodium Inhibitor 96.95% Unkown
HY-109165 Acoramidis 98.47% Unkown
HY-112974 Inotersen Inhibitor 96.44% Unkown
HY-109165A Acoramidis hydrochloride 98.70% Unkown
HY-14852R Tafamidis (Standard) Inhibitor 99.24% Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-132589 Vutrisiran 97.37% Phase 3
HY-148089 Eplontersen Inhibitor 98.70% Phase 3
HY-177650 Nucresiran Inhibitor 97.24% Phase 3
HY-185504 Nexiguran / Phase 3
HY-132590 Revusiran / Phase 3
HY-177650A Nucresiran sodium Inhibitor / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990734 Coramitug Inhibitor 99.00% Phase 1

Pre-clinical Phase

Bioactive Molecules (22)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N1957 Gamma-Mangostin 99.91% Unkown
HY-113283 Homogentisic acid 99.68% Unkown
HY-132590A Revusiran sodium Inhibitor 93.16% Unkown
HY-153609 AS-Patisiran sodium Inhibitor 95.10% Unkown
HY-W331198 Tralopyril Inducer 99.70% Unkown
HY-113950 Dichlorophenyl-ABA 99.79% Unkown
HY-153577 WT-TTR inhibitor 1 Inhibitor 98.03% Unkown
HY-RS15238 TTR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-165604 C14-490 98% Unkown
HY-146137 Transthyretin-IN-1 / Unkown
HY-147366 RBP4 ligand-1 Inhibitor / Unkown
HY-14852S Tafamidis-d3 / Unkown
HY-155299 PITB Inhibitor / Unkown
HY-159658 TTR stabilizer 1 Modulator / Unkown
HY-161505 Transthyretin-IN-3 Inhibitor / Unkown
HY-P10615 Abz-YGGRASDQ-EDDnp / Unkown
HY-P11698 Guanidino-G-Clamp-PNA Inhibitor / Unkown
HY-RS15239 Ttr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15240 Ttr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-126927 TTR stabilizer L6 Modulator / Unkown
HY-160612 Transthyretin-IN-2 Inhibitor / Unkown
HY-176233 Transthyretin-IN-4 Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991128 Cliramitug 97.0% Unkown
HY-P991412 NI-301 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ttr NCBI NCBI:7276