Vdr - vitamin D (1,25-dihydroxyvitamin D3) receptor Gene

Also Known as Nr1i1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22337

About Vdr

Chromosome 15: 97,752,306-97,808,511 reverse strand.GRCm39:CM001008.3

This gene has 6 transcripts (splice variants), 462 orthologues, 19 paralogues and is associated with 131 phenotypes. Biased expression in duodenum adult (RPKM 78.3), colon adult (RPKM 58.5) and 3 other tissues.

Summary

Enables DNA binding activity and nuclear receptor activity. Involved in regulation of calcidiol 1-monooxygenase activity. Acts upstream of or within several processes, including intestinal absorption; mammary gland development; and positive regulation of apoptotic process involved in mammary gland involution. Predicted to be located in several cellular components, including T-tubule; chromatin; and nuclear lumen. Predicted to be part of RNA polymerase II transcription regulator complex and receptor complex. Predicted to colocalize with caveola. Is expressed in several structures, including alimentary system; metanephros; nervous system; sensory organ; and skeleton. Used to study osteoporosis and rickets. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); lipid storage disease (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2022]

Vdr Products (1)

mRNA Protein Name
NM_009504.4 NP_033530.2 vitamin D3 receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15601870 MGI
enables nuclear receptor activity IDA
IDA: Inferred from direct assay
15322135 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8978696 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
9241280 MGI
acts upstream of apoptotic process involved in mammary gland involution IMP
IMP: Inferred from mutant phenotype
15178742 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
11687634 MGI
acts upstream of or within intestinal absorption IMP
IMP: Inferred from mutant phenotype
11687634 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
9241280 MGI
acts upstream of or within lactation IMP
IMP: Inferred from mutant phenotype
15178742 MGI
acts upstream of or within mammary gland branching involved in pregnancy IMP
IMP: Inferred from mutant phenotype
15178742 MGI
acts upstream of or within multicellular organism development IMP
IMP: Inferred from mutant phenotype
9241280 MGI
acts upstream of or within positive regulation of apoptotic process involved in mammary gland involution IMP
IMP: Inferred from mutant phenotype
15178742 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15322135 MGI
involved in regulation of calcidiol 1-monooxygenase activity IMP
IMP: Inferred from mutant phenotype
9295274 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
9241280 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Vdr Protein Structure

NR_DBD_VDR

NR_DBD_VDR: cd06955 (15 - 121)

NR_LBD_VDR

NR_LBD_VDR: cd06933 (123 - 420)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 422 a.a.
Protein Preferred Names Protein Names

vitamin D3 receptor

  • 1,25-dihydroxyvitamin D3 receptor

  • nuclear receptor subfamily 1 group I member 1

  • vitamin D receptor

Recombinant Vdr Proteins

Cat. No. Product Name Accession Purity
HY-P73542 Vitamin D Receptor/VDR Protein, Mouse (sf9, His) P48281 (M1-S422) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10002 Calcitriol Agonist 99.94% Unkown
HY-32351 Calcifediol 99.94% Unkown
HY-10003 Alfacalcidol Activator 99.96% Unkown
HY-32339 Maxacalcitol Activator 99.71% Unkown
HY-32351A Calcifediol monohydrate 99.98% Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-32344 Inecalcitol 98.44% Phase 2
HY-32345 Elocalcitol 99.2% Phase 2
HY-14863 Lunacalcipol / Phase 2
HY-32351S3 Calcifediol-d9 / Phase 2
HY-B1844 Flucythrinate / Phase 1

Pre-clinical Phase

Bioactive Molecules (60)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147337 MeTC7 Antagonist 98.50% Unkown
HY-32343 Secalciferol Activator 99.85% Unkown
HY-12407 ZK168281 Antagonist 98.0% Unkown
HY-76814 Calcitriol-d6 Activator 99.27% Unkown
HY-32350 Ercalcitriol Activator 99.71% Unkown
HY-13332 Calcifediol-d6 Activator 99.09% Unkown
HY-12398 TEI-9647 Agonist 99.10% Unkown
HY-103053 PS121912 Inhibitor 96.40% Unkown
HY-10002A (1S)-Calcitriol 98.52% Unkown
HY-12397 ZK159222 Antagonist 99.23% Unkown
HY-12398A TEI-9648 Inhibitor 99.24% Unkown
HY-77278 25-Hydroxytachysterol3 Agonist 98.07% Unkown
HY-15329 Maxacalcitol-d6 Activator 96.03% Unkown
HY-32351S Calcifediol-d3 98.96% Unkown
HY-131492 Δ4-Dafachronic acid Ligand 96.93% Unkown
HY-RS15632 VDR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-131961 Triciferol 98.61% Unkown
HY-N10508 Calcitroic acid Agonist 85.0% Unkown
HY-13294 Impurity C of Alfacalcidol Activator 99.81% Unkown
HY-15332 Alfacalcidol-d6 Activator 98.0% Unkown
HY-32351AS Calcifediol-d6 monohydrate 97.50% Unkown
HY-13293 Impurity C of Calcitriol Activator 99.84% Unkown
HY-RS15633 Vdr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-154825 20-Hydroxyvitamin D3 ≥98.0% Unkown
HY-77274 Calcitriol Impurities D Activator 95.18% Unkown
HY-114310 VDR agonist 1 / Unkown
HY-10002B (1R,5Z)-Calcitriol Control / Unkown
HY-119612 XCT0135908 / Unkown
HY-10002AS (1S)-Calcitriol-d3 / Unkown
HY-10002AS2 (1S)-Calcitriol-d6 / Unkown
HY-10002S1 Calcitriol-d3 / Unkown
HY-10002S2 Calcitriol-d9 / Unkown
HY-10003S Alfacalcidol-d7 Activator / Unkown
HY-117182 LG190178 / Unkown
HY-118970 LG190155 / Unkown
HY-131492S Δ4-Dafachronic Acid-d3 Ligand / Unkown
HY-149899 VDR agonist 2 Agonist / Unkown
HY-15364 19-nor-1α,25-Dihydroxyvitamin D3 Ligand / Unkown
HY-161778 ZG-126 / Unkown
HY-163947 UG-480 Modulator / Unkown
HY-166525S 24R-Calcipotriol-d4 Activator / Unkown
HY-170975 UG-650 Ligand / Unkown
HY-172087 VDR agonist 3 Agonist / Unkown
HY-173393 LXRα agonist 1 Agonist / Unkown
HY-178328 VDR agonist 4 / Unkown
HY-178336 AC-340 / Unkown
HY-179431 VDR ligand-1 Agonist / Unkown
HY-181486 VDR agonist 5 Agonist / Unkown
HY-182038 TGF-β1/Smad3-IN-2 / Unkown
HY-19380 Ro-65-2299 Agonist / Unkown
HY-32351AS1 Calcifediol-13C5 monohydrate / Unkown
HY-N10508S Calcitroic acid-13C / Unkown
HY-RS03451 CYP27B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15634 Vdr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-10002S Calcitriol-13C3 Inhibitor 97.0% Unkown
HY-177795 5β-Cholanic acid-3,6-dione / Unkown
HY-180503 19-Nor-22-oxa-1a,25(OH)2-VD3 / Unkown
HY-32350S1 Ercalcitriol-d3 Activator / Unkown
HY-RS16287 Cyp27b1 Mouse Pre-designed siRNA Set A / Unkown
HY-107218 11-Hydroxysugiol Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vdr NCBI NCBI:7421