Pim3 - proviral integration site 3 Gene

Also Known as Kid1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 223775

About Pim3

Chromosome 15: 88,746,389-88,749,929 forward strand.GRCm39:CM001008.3

This gene has 2 transcripts (splice variants), 220 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in adrenal adult (RPKM 73.4), duodenum adult (RPKM 37.2) and 26 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activity. Involved in negative regulation of Insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in spleen. Orthologous to human PIM3 (Pim-3 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Pim3 Products (1)

mRNA Protein Name
NM_145478.2 NP_663453.1 serine/threonine-protein kinase pim-3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21099329 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
21099329 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pim3 Protein Structure

PKc_like

PKc_like: cl21453 (38 - 292)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase pim-3

  • KID-1/kinase induced by depolarization

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-101870B Uzansertib phosphate Inhibitor 99.77% Phase 2
HY-101870 Uzansertib Inhibitor 99.45% Phase 2
HY-19322 PIM447 Inhibitor 99.52% Phase 1
HY-19322B PIM-447 dihydrochloride Inhibitor 99.82% Phase 1

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16976 GDC-0339 Inhibitor 99.87% Unkown
HY-120758 SEL24-B489 Inhibitor 99.02% Unkown
HY-122665 HTH-01-091 Inhibitor 99.81% Unkown
HY-111552 PIM1-IN-1 Inhibitor 99.83% Unkown
HY-164460 AZD1897 Inhibitor 99.69% Unkown
HY-123983 HS56 Inhibitor 99.6% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-101783 GNE-955 Inhibitor / Unkown
HY-186146 SGI-1776-VHL-02 Degrader 96.67% Unkown
HY-181925 FD2024 Inhibitor / Unkown
HY-122670 VS-II-173 Inhibitor / Unkown
HY-N13352 Bufothionine Inhibitor / Unkown
HY-163442A PIM3-IN-1 hydrochloride Inhibitor / Unkown
HY-168479 VB1080 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pim3 NCBI NCBI:415116