PIM3 - Pim-3 proto-oncogene, serine/threonine kinase Gene

Also Known as pim-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 415116

About PIM3

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:49,960,772-49,964,072 (from NCBI)

This gene has 2 transcripts (splice variants), 220 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 36.0), stomach (RPKM 21.6) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and Pim subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]

PIM3 Products (1)

mRNA	Protein	Name
NM_001001852.4	NP_001001852.2	serine/threonine-protein kinase pim-3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17270021	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18593906	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17270021	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	18593906	GOA
involved in regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	17270021	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIM3 Protein Structure

Pkinase

0
100
200
300
326 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase pim-3	pim-3 oncogene serine/threonine kinase Pim-3

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia, X-Linked 5	SCAX5 X-Linked Spinocerebellar Ataxia 5 X-Linked Non Progressive Cerebellar Ataxia
Hepatic Flexure Cancer	Ca Hepatic Flexure - Colon Malignant Neoplasm Of Hepatic Flexure Malignant Tumor Of Hepatic Flexure Carcinoma Of Hepatic Flexure Malignant Neoplasm Of Hepatic Flexure Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101870B	Uzansertib phosphate	Inhibitor	99.77%	Phase 2
HY-101870	Uzansertib	Inhibitor	99.45%	Phase 2
HY-19322	PIM447	Inhibitor	99.52%	Phase 1
HY-19322B	PIM-447 dihydrochloride	Inhibitor	99.82%	Phase 1

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16976	GDC-0339	Inhibitor	99.87%	Unkown
HY-120758	SEL24-B489	Inhibitor	99.02%	Unkown
HY-122665	HTH-01-091	Inhibitor	99.81%	Unkown
HY-111552	PIM1-IN-1	Inhibitor	99.83%	Unkown
HY-164460	AZD1897	Inhibitor	99.69%	Unkown
HY-123983	HS56	Inhibitor	99.6%	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-101783	GNE-955	Inhibitor	/	Unkown
HY-186146	SGI-1776-VHL-02	Degrader	96.67%	Unkown
HY-181925	FD2024	Inhibitor	/	Unkown
HY-122670	VS-II-173	Inhibitor	/	Unkown
HY-N13352	Bufothionine	Inhibitor	/	Unkown
HY-163442A	PIM3-IN-1 hydrochloride	Inhibitor	/	Unkown
HY-168479	VB1080	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PIM3	VGNC	VGNC:107916
Mus musculus	PIM3	MGD	MGI:1355297
Bos taurus	PIM3	VGNC	VGNC:32901
Rattus norvegicus	PIM3	RGD	RGD:620462
Others	PIM3	NCBI