2. Gene
  3. PIM3 - Pim-3 proto-oncogene, serine/threonine kinase Gene

PIM3 - Pim-3 proto-oncogene, serine/threonine kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as pim-3

Gene ID: 415116 | Gene type: protein coding

About PIM3

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:49,960,772-49,964,072 (from NCBI)

This gene has 2 transcripts (splice variants), 220 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 36.0), stomach (RPKM 21.6) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and Pim subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]

PIM3 Products(1)

mRNA Protein Name
NM_001001852.4 NP_001001852.2 serine/threonine-protein kinase pim-3

PIM3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (40 - 293)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase pim-3

pim-3 oncogene

serine/threonine kinase Pim-3

Related Diseases

Diseases Alias
Spinocerebellar Ataxia, X-Linked 5

SCAX5

X-Linked Spinocerebellar Ataxia 5

X-Linked Non Progressive Cerebellar Ataxia
Hepatic Flexure Cancer

Ca Hepatic Flexure - Colon

Malignant Neoplasm Of Hepatic Flexure

Malignant Tumor Of Hepatic Flexure

Carcinoma Of Hepatic Flexure

Malignant Neoplasm Of Hepatic Flexure Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-101870B Uzansertib phosphate Inhibitor 99.39% Phase 2
HY-19322B PIM-447 dihydrochloride Inhibitor 99.94% Phase 1
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16976 GDC-0339 Inhibitor 99.77% Unkown
HY-120758 SEL24-B489 Inhibitor 98.58% Unkown
HY-111552 PIM1-IN-1 Inhibitor 99.51% Unkown
HY-122665 HTH-01-091 Inhibitor 98.64% Unkown
HY-101870 Uzansertib Inhibitor / Unkown
HY-101783 GNE-955 Inhibitor / Unkown
HY-123983 HS56 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PIM3 VGNC VGNC:107916
Mus musculus PIM3 MGD MGI:1355297
Bos taurus PIM3 VGNC VGNC:32901
Rattus norvegicus PIM3 RGD RGD:620462
Others PIM3 NCBI