FGF4 - fibroblast growth factor 4 Gene

Also Known as HST; KFGF; FGF-4; HST-1; HSTF1; K-FGF; HBGF-4; HSTF-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2249

About FGF4

Cytogenetic location: 11q13.3 Genomic coordinates (GRCh38): 11:69,771,022-69,775,341 (from NCBI)

This gene has 2 transcripts (splice variants), 258 orthologues and 21 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the Fibroblast Growth Factor (FGF) family. FGF Family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic Hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]

FGF4 Products (1)

mRNA Protein Name
NM_002007.4 NP_001998.1 fibroblast growth factor 4 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in chondroblast differentiation IDA
IDA: Inferred from direct assay
17167778 GOA
acts upstream of or within fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
8663044 GOA
involved in mesenchymal cell proliferation IDA
IDA: Inferred from direct assay
11023873 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
17167778 GOA
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
8663044 GOA
involved in regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
IDA: Inferred from direct assay
16756958 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGF4 Protein Structure

FGF

FGF: Fibroblast growth factor (82 - 203)

  • 0
  • 100
  • 206 a.a.
Protein Preferred Names Protein Names

fibroblast growth factor 4

  • heparin secretory transforming protein 1

Recombinant FGF4 Proteins

Cat. No. Product Name Accession Purity
HY-P7014 FGF-4 Protein, Human P08620-1 (A31-L206) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70694 FGF-4 Protein, Human (153a.a) P08620-1 (S54-L206) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700066AF Animal-Free FGF-4 Protein, Human (His) P08620-1 (G25-L206) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700288 FGF-4 Protein, Human (136a.a) P08620-1 (S71-L206) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Embryonal Carcinoma

  • Embryonal Neoplasm

  • Embryonal Cancer

  • Primary Extragonadal Embryonal Carcinoma

  • Embryo Neoplasm

  • Carcinoma Embryonal

  • Cancer Embryonal

  • Carcinoma, Embryonal

  • Extragonadal Embryonal Carcinoma

  • Cancer, Embryonal
Germ Cell Cancer

  • Malignant Germ Cell Tumor

  • Neoplasms, Germ Cell And Embryonal

  • Germ Cell Neoplasm

  • Germ Cell Tumour

  • Malignant Tumor Of The Germ Cell

  • Neoplasms Germ Cell

  • Malignant Germ Cell Neoplasm
Teratocarcinoma

  • Mixed Embryonal Carcinoma And Teratoma
Kaposi Sarcoma

  • Kaposi'S Sarcoma

  • Kaposi Sarcoma, Susceptibility To

  • Kaposi'S Sarcoma Of Lung

  • Kaposi'S Sarcoma Of Palate

  • Kaposi'S Sarcoma Of Soft Tissue

  • Kaposi'S Sarcoma-Associated Herpesvirus

  • Multiple Idiopathic Pigmented Hemangiosarcoma

  • Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To

  • African Lymphadenopathic Kaposi'S Sarcoma

  • Anal Kaposi'S Sarcoma

  • Cardiac Kaposi'S Sarcoma

  • Central Nervous System Kaposi'S Sarcoma

  • Conjunctival Kaposi'S Sarcoma

  • Corneal Kaposi'S Sarcoma

  • Cutaneous Kaposi'S Sarcoma

  • Esophageal Kaposi'S Sarcoma

  • Gallbladder Kaposi'S Sarcoma

  • Gastric Kaposi'S Sarcoma

  • Intestinal Kaposi'S Sarcoma

  • Kaposi'S Sarcoma Of Anus

  • Kaposi'S Sarcoma Of Central Nervous System

  • Kaposi'S Sarcoma Of Conjunctiva

  • Kaposi'S Sarcoma Of Cornea

  • Kaposi'S Sarcoma Of Esophagus

  • Kaposi'S Sarcoma Of Gastrointestinal Sites

  • Kaposi'S Sarcoma Of Heart

  • Kaposi'S Sarcoma Of Lymph Nodes

  • Kaposi'S Sarcoma Of Penis

  • Kaposi'S Sarcoma Of Skin

  • Kaposi'S Sarcoma Of Soft Tissues

  • Kaposi'S Sarcoma Of The Cns

  • Kaposi'S Sarcoma Of The Gallbladder

  • Kaposi'S Sarcoma Of The Prostate

  • Kaposi'S Sarcoma, Lung

  • Kaposi'S Sarcoma, Skin

  • Lymph Node Kaposi'S Sarcoma

  • Lymphadenopathic Kaposi'S Sarcoma

  • Palate Kaposi'S Sarcoma

  • Penis Kaposi'S Sarcoma

  • Prostate Kaposi'S Sarcoma

  • Pulmonary Kaposi'S Sarcoma

  • Soft Tissue Kaposi'S Sarcoma

  • Hhv8

  • Human Herpesvirus 8

  • Kshv

  • Kaposi Sarcoma Herpesvirus

  • Mediterranean Kaposi Sarcoma

  • Non Aids Related Kaposi Sarcoma

  • Sarcoma, Kaposi

  • Sarcoma, Kaposi, Susceptibility To

  • Non-Aids-Related Kaposi Sarcoma

  • Angiolymphoid Hyperplasia

  • Angiofollicular Ganglionic Hyperplasia

  • Multi-Centric Castleman'S Disease
Apert Syndrome

  • Acrocephalosyndactyly Type I

  • Acs1

  • Acrocephalosyndactylia

  • Acrocephalosyndactyly

  • Acs I

  • Apert-Crouzon Disease

  • Acrocephalosyndactyly Type 1

  • Acrocephalosyndactyly, Type I

  • Acs 1

  • Acrocephalo-Syndactyly Type 1

  • Syndactylic Oxycephaly

  • Apert'S Syndrome

  • Type I Acrocephalosyndactyly

  • APRS
Craniosynostosis

  • Premature Closure Of Cranial Sutures

  • Craniostenosis

  • Craniosynostosis Syndrome

  • Cso

  • Craniosynostoses

  • Congenital Ossification Of Cranial Sutures

  • Congenital Ossification Of Sutures Of Skull

  • Craniostosis

  • Imperfect Fusion Of Skull

  • Congenital Imperfect Closure Skull

  • Imperfect Closure Skull

  • Premature Closure Cranium Sutures

  • Deficiency Of Craniofacial Axis
Sarcoma

  • Connective And Soft Tissue Neoplasm

  • Tumor Of Soft Tissue And Skeleton

  • Sarcomas

  • Sarcoma - Category
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Polydactyly

  • Non-Syndromic Polydactyly

  • Polydactyly, Postaxial

  • Postaxial Polydactyly

  • Supernumerary Digit

  • Extra Digits

  • Hyperdactyly

  • Polydactylia

  • Polydactylism

  • Supernumerary Digits
Intellectual Developmental Disorder With Short Stature And Behavioral Abnormalities

  • IDDSSBA
Male Urethral Cancer

  • Male Urethral Malignant Neoplasm
Lacrimoauriculodentodigital Syndrome

  • Ladd Syndrome

  • Levy-Hollister Syndrome

  • Lacrimo-Auriculo-Dento-Digital Syndrome

  • LADD

  • Lacrimoauriculodento-Digital Syndrome

  • Levy Hollister Syndrome

  • Lard Syndrome

  • Lacrimoauriculoradiodental Syndrome

  • LADDS

  • Congenital Duodenal Obstruction Due To Malrotation Of Intestine
Endometrial Cancer

  • Endometrial Carcinoma

  • Endometrial Neoplasm

  • Malignant Neoplasm Of Endometrium

  • Endometrioid Carcinoma

  • Endometrial Neoplasms

  • Carcinoma, Endometrioid

  • Endometrial Cancer, Familial

  • Endometrial Carcinoma, Somatic

  • Endometrial Cancer, Susceptibility To

  • Endometrial Ca

  • Malignant Endometrial Neoplasm

  • Neoplasm Of Endometrium

  • Primary Malignant Neoplasm Of Endometrium

  • Tumor Of Endometrium

  • Carcinoma Of The Endometrium

  • Endometrioid Carcinoma Of Female Reproductive System

  • ENDMC

  • Carcinoma Endometrioid

  • Endometrial Cancers

  • Cancer, Endometrial

  • Uterine Corpus Cancer
Esophageal Cancer

  • Esophageal Carcinoma

  • Carcinoma Of Esophagus

  • Esophageal Squamous Cell Carcinoma, Somatic

  • Esophageal Carcinoma, Somatic

  • Esophagus Cancer

  • Gastric Cardia Adenocarcinoma

  • Esophageal Neoplasms

  • Esophageal Cancer, Somatic

  • Cancer Of Esophagus

  • Cancer Of Oesophagus

  • Carcinoma Of Oesophagus

  • Ca Lower Third Oesophagus

  • Ca Middle Third Oesophagus

  • Malignant Neoplasm Of Distal Third Of Esophagus

  • Malignant Neoplasm Of Lower Third Of Oesophagus

  • Malignant Neoplasm Of Middle Third Of Oesophagus

  • Malignant Neoplasm Of Proximal Third Of Esophagus

  • Malignant Neoplasm Of Upper Third Esophagus

  • Malignant Tumor Of Abdominal Esophagus

  • Malignant Tumor Of Distal Third Of Esophagus

  • Malignant Tumor Of Proximal Third Of Esophagus

  • Malignant Tumor Of The Middle Third Of The Esophagus

  • ESCR

  • Aerodigestive Tract Cancer

  • Escc

  • Esophageal Squamous Cell Carcinoma

  • Cancer, Esophageal

  • Malignant Neoplasm Of Esophagus

  • Squamous Cell Carcinoma Of Esophagus

  • Malignant Neoplasm Of Middle Third Of Esophagus
Crouzon Syndrome

  • Crouzon Craniofacial Dysostosis

  • Craniofacial Dysostosis

  • Cfd1

  • Craniofacial Dysostosis Type 1

  • Crouzon Disease

  • Crouzon'S Disease

  • Craniofacial Dysostosis, Type I

  • Craniofacial Dysarthrosis

  • Craniofacial Dysostosis Syndrome

  • CS

  • Craniofacial Dysostosis Type I

  • Vogt Cephalosyndactyly
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Chromosome 2q35 Duplication Syndrome

  • Syndactyly

  • Syndactyly Type 1

  • Sdty1

  • Zygodactyly

  • Syndactyly, Type I

  • Sd1

  • Syndactyly, Type 1, With Or Without Craniosynostosis

  • Symphalangism

  • Non-Syndromic Syndactyly

  • Symphalangy

  • Webbing Of Digits

  • Syndactyly, Type 1
Osteochondrodysplasia

  • Skeletal Dysplasia

  • Chondrodystrophy

  • Congenital Anomaly Of Cartilage

  • Osteochondrodysplasias

  • Cartilage Development Disorder

  • Osteochondrodysplasia Syndrome

  • Dysplasia, Skeletal

  • Mucopolysaccharidosis Iv
Tooth Agenesis

  • Oligodontia

  • Hypodontia

  • Selective Tooth Agenesis

  • Tooth Agenesis, Selective

  • Familial Tooth Agenesis

  • Anodontia

  • Congenital Absence Of One Tooth
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04902 FGF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174696 Human FGF4 mRNA / Unkown
HY-RS16649 Fgf4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23084 Fgf4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FGF4 VGNC VGNC:110505
Mus musculus FGF4 MGD MGI:95518
Felis catus FGF4 VGNC VGNC:102886
Canis familiaris FGF4 VGNC VGNC:40850
Rattus norvegicus FGF4 RGD RGD:620127
Others FGF4 NCBI