PHLPP2 - PH domain and leucine rich repeat protein phosphatase 2 Gene

Homo sapiens

Also known as PPM3B; PHLPPL

Gene ID: 23035 | Gene type: protein coding

About PHLPP2

Cytogenetic location: 16q22.2 Genomic coordinates (GRCh38): 16:71,644,924-71,724,701 (from NCBI)

This gene has 7 transcripts (splice variants), 186 orthologues and 31 paralogues. Broad expression in small intestine (RPKM 11.5), colon (RPKM 5.9) and 22 other tissues.

Summary

Predicted to enable protein serine/threonine Phosphatase activity. Predicted to be involved in signal transduction. Located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PHLPP2 Products(2)

mRNA	Protein	Name
NM_001289003.1	NP_001275932.1	PH domain leucine-rich repeat-containing protein phosphatase 2 isoform 2
NM_015020.3	NP_055835.2	PH domain leucine-rich repeat-containing protein phosphatase 2 isoform 1

PHLPP2 Protein Structure

LRR_1

LRR_8

PP2C

0
300
600
900
1200
1323 a.a.

Protein Preferred Names

Protein Names

PH domain leucine-rich repeat-containing protein phosphatase 2

protein phosphatase, Mg2+/Mn2+ dependent 3B

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Optic Atrophy 8

OPA8

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-19820A	NSC45586 sodium	≥98.0%	Unkown
HY-19820	NSC45586	/	Unkown
HY-RS10448	PHLPP2 Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PHLPP2	VGNC	VGNC:44505
Bos taurus	PHLPP2	VGNC	VGNC:32841
Felis catus	PHLPP2	VGNC	VGNC:97553
Macaca mulatta	PHLPP2	VGNC	VGNC:81494
Rattus norvegicus	PHLPP2	RGD	RGD:1562857
Mus musculus	PHLPP2	MGD	MGI:2444928

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