PHLPP2 - PH domain and leucine rich repeat protein phosphatase 2 Gene

Also Known as PPM3B; PHLPPL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23035

About PHLPP2

Cytogenetic location: 16q22.2 Genomic coordinates (GRCh38): 16:71,644,924-71,724,701 (from NCBI)

This gene has 7 transcripts (splice variants), 186 orthologues and 31 paralogues. Broad expression in small intestine (RPKM 11.5), colon (RPKM 5.9) and 22 other tissues.

Summary

Predicted to enable protein serine/threonine Phosphatase activity. Predicted to be involved in signal transduction. Located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PHLPP2 Products (2)

mRNA Protein Name
NM_001289003.1 NP_001275932.1 PH domain leucine-rich repeat-containing protein phosphatase 2 isoform 2
NM_015020.3 NP_055835.2 PH domain leucine-rich repeat-containing protein phosphatase 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18162466 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHLPP2 Protein Structure

LRR_1

LRR_1: Leucine Rich Repeat (324 - 344)

LRR_1

LRR_1: Leucine Rich Repeat (346 - 367)

LRR_8

LRR_8: Leucine rich repeat (572 - 632)

LRR_8

LRR_8: Leucine rich repeat (645 - 703)

PP2C

PP2C: Protein phosphatase 2C (849 - 1026)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1323 a.a.
Protein Preferred Names Protein Names

PH domain leucine-rich repeat-containing protein phosphatase 2

  • protein phosphatase, Mg2+/Mn2+ dependent 3B

PHLPP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PHLPP2 Q6ZVD8 NHERF1 Homo sapiens O14745
Filter Binding
21804599
Intra
PHLPP2 Q6ZVD8 NHERF1 Homo sapiens O14745
Anti Tag CoIP
27880917
Intra
PHLPP2 Q6ZVD8 NHERF1 Homo sapiens O14745
Pull Down
21804599
Intra
PHLPP2 Q6ZVD8 NHERF1 Homo sapiens O14745
Anti Tag CoIP
19615732
Intra
PHLPP2 Q6ZVD8 PRKCB Homo sapiens P05771-2
Cosedimentation
18162466
Cross: Cross-species interaction Intra: Intraspecies interaction

PHLPP2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81348 PHLPP2 Antibody (YA1093) IHC-P Human
HY-P81348A PHLPP2 Antibody (YA1093)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Optic Atrophy 8

  • OPA8
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19820A NSC45586 sodium 98.0% Unkown
HY-19820 NSC45586 / Unkown
HY-RS10448 PHLPP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19800 Phlpp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26296 Phlpp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PHLPP2 VGNC VGNC:44505
Bos taurus PHLPP2 VGNC VGNC:32841
Felis catus PHLPP2 VGNC VGNC:97553
Macaca mulatta PHLPP2 VGNC VGNC:81494
Rattus norvegicus PHLPP2 RGD RGD:1562857
Mus musculus PHLPP2 MGD MGI:2444928
Others PHLPP2 NCBI