CAND2 - cullin associated and neddylation dissociated 2 (putative) Gene

Also Known as Tp120b; TIP120B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23066

About CAND2

Cytogenetic location: 3p25.2 Genomic coordinates (GRCh38): 3:12,796,680-12,834,803 (from NCBI)

This gene has 6 transcripts (splice variants), 191 orthologues and 1 paralogue. Broad expression in heart (RPKM 9.1), testis (RPKM 8.9) and 16 other tissues.

Summary

Predicted to enable TBP-class protein binding activity. Predicted to be involved in SCF complex assembly; positive regulation of transcription, DNA-templated; and protein ubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CAND2 Products (2)

mRNA Protein Name
NM_001162499.2 NP_001155971.1 cullin-associated NEDD8-dissociated protein 2 isoform 1
NM_012298.3 NP_036430.1 cullin-associated NEDD8-dissociated protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12207886 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
12692129 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAND2 Protein Structure

HEAT_EZ

HEAT_EZ: HEAT-like repeat (842 - 888)

TIP120

TIP120: TATA-binding protein interacting (TIP20) (1044 - 1209)

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  • 1000
  • 1236 a.a.
Protein Preferred Names Protein Names

cullin-associated NEDD8-dissociated protein 2

  • TBP interacting protein

CAND2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CAND2 O75155 FHL2 Homo sapiens Q14192
Validated Y2H
32296183
Intra
CAND2 O75155 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra
CAND2 O75155 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra
CAND2 O75155 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra
CAND2 O75155 SYP Homo sapiens P08247
Validated Y2H
32296183
Intra
CAND2 O75155 SYP Homo sapiens P08247
Y2H Array
32296183
Intra
CAND2 O75155 SYP Homo sapiens P08247
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Clubfoot

  • Congenital Talipes Equinovarus

  • Congenital Clubfoot

  • Congenital Equinovarus

  • Equinovarus Deformity Of Foot

  • Club Foot
Prostatic Adenoma

  • Prostatic Hyperplasia

  • Adenoma - Prostate

  • Adenoma Of Prostate

  • Benign Adenoma Of Prostate

  • Prostate Adenoma

  • Benign Prostatic Hyperplasia
Male Reproductive Organ Benign Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01877 CAND2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CAND2 RGD RGD:620480
Macaca mulatta CAND2 VGNC VGNC:84220
Canis familiaris CAND2 VGNC VGNC:54586
Felis catus CAND2 VGNC VGNC:102018
Mus musculus CAND2 MGD MGI:1914338
Others CAND2 NCBI