Ece1 - endothelin converting enzyme 1 Gene

Also Known as ECE-1; ECE-1a; ECE-1b; ECE-1d; ECE-1c1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230857

Summary

Predicted to enable metalloendopeptidase activity; protein homodimerization activity; and zinc ion binding activity. Involved in axonogenesis; embryonic heart tube development; and gene expression. Acts upstream of or within pharyngeal system development. Predicted to be located in several cellular components, including cytoplasmic vesicle; external side of plasma membrane; and perinuclear region of cytoplasm. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; male reproductive gland or organ; respiratory system; and sensory organ. Used to study double outlet right ventricle. Human ortholog(s) of this gene implicated in Alzheimer's disease; congestive heart failure; coronary artery disease; essential hypertension; and hypertension. Orthologous to human ECE1 (endothelin converting enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]

Ece1 Products (4)

mRNA Protein Name
NM_001369177.1 NP_001356106.1 endothelin-converting enzyme 1 isoform a
NM_001369178.1 NP_001356107.1 endothelin-converting enzyme 1 isoform b
NM_001369179.1 NP_001356108.1 endothelin-converting enzyme 1 isoform c
NM_199307.2 NP_955011.1 endothelin-converting enzyme 1 isoform c

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in axon guidance IMP
IMP: Inferred from mutant phenotype
30735130 MGI
involved in axonogenesis involved in innervation IMP
IMP: Inferred from mutant phenotype
30735130 MGI
involved in embryonic heart tube development IMP
IMP: Inferred from mutant phenotype
30735130 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
30735130 MGI
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
24875861 MGI
acts upstream of or within pharyngeal system development IMP
IMP: Inferred from mutant phenotype
12950083 MGI
involved in semaphorin-plexin signaling pathway involved in axon guidance IMP
IMP: Inferred from mutant phenotype
30735130 MGI
involved in sympathetic neuron axon guidance IMP
IMP: Inferred from mutant phenotype
30735130 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endothelin-converting enzyme 1

  • endothelin-converting enzyme-1a

  • endothelin-converting enzyme-1b

  • endothelin-converting enzyme-1c1

  • endothelin-converting enzyme-1d

Orthologs Information

Species Symbol Source ID
Homo sapiens Ece1 NCBI NCBI:1889