Phgdh - 3-phosphoglycerate dehydrogenase Gene

Also Known as A10; PGD; PGAD; PGDH; SERA; 3PGDH; 3-PGDH; 4930479N23

Species: Mus musculus

Gene Type: protein coding

Gene ID: 236539

About Phgdh

Chromosome 3: 98,220,486-98,247,306 reverse strand.GRCm39:CM000996.3

This gene has 4 transcripts (splice variants), 217 orthologues, 3 paralogues and is associated with 56 phenotypes. Broad expression in placenta adult (RPKM 138.), genital fat pad adult (RPKM 127.9) and 25 other tissues.

Summary

Predicted to enable phosphoglycerate dehydrogenase activity. Acts upstream of or within several processes, including G1 to G0 transition; cellular amino acid metabolic process; and nervous system development. Located in myelin sheath. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Phgdh Products (1)

mRNA	Protein	Name
NM_016966.3	NP_058662.2	D-3-phosphoglycerate dehydrogenase

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within G1 to G0 transition	IMP IMP: Inferred from mutant phenotype	19114063	MGI
acts upstream of or within L-serine metabolic process	IMP IMP: Inferred from mutant phenotype	19114063	MGI
acts upstream of or within gamma-aminobutyric acid metabolic process	IMP IMP: Inferred from mutant phenotype	19114063	MGI
acts upstream of or within glial cell development	IMP IMP: Inferred from mutant phenotype	19114063	MGI
acts upstream of or within glutamine metabolic process	IMP IMP: Inferred from mutant phenotype	19114063	MGI
acts upstream of or within glycine metabolic process	IMP IMP: Inferred from mutant phenotype	19114063	MGI
acts upstream of or within neural tube development	IMP IMP: Inferred from mutant phenotype	19114063	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	19114063	MGI
acts upstream of or within neuron projection development	IMP IMP: Inferred from mutant phenotype	19114063	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19114063	MGI
acts upstream of or within spinal cord development	IMP IMP: Inferred from mutant phenotype	19114063	MGI
acts upstream of or within taurine metabolic process	IMP IMP: Inferred from mutant phenotype	19114063	MGI
acts upstream of or within threonine metabolic process	IMP IMP: Inferred from mutant phenotype	19114063	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Phgdh Protein Structure

PGDH_4

PGDH_inter

0
100
200
300
400
500
533 a.a.

Protein Preferred Names	Protein Names
D-3-phosphoglycerate dehydrogenase	3-phosphoglycerate dehyrogenase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (24)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101966	NCT-503	Inhibitor	99.69%	Unkown
HY-100012	CBR-5884		99.02%	Unkown
HY-141412	D-(-)-3-Phosphoglyceric acid disodium	Inhibitor	99.43%	Unkown
HY-123269	PKUMDL-WQ-2101	Inhibitor	99.94%	Unkown
HY-126253	BI-4916		98.67%	Unkown
HY-117240	NCT-502		98.59%	Unkown
HY-126254	BI-4924		99.55%	Unkown
HY-121733	PHGDH-inactive		99.93%	Unkown
HY-123418	PKUMDL-WQ-2201	Inhibitor	98.45%	Unkown
HY-148570	PHGDH-IN-3	Inhibitor	99.34%	Unkown
HY-177742	LXH-3-71	Degrader	97.19%	Unkown
HY-161456	PHGDH-IN-5	Inhibitor	98.12%	Unkown
HY-165298	DGY-09-192		99.50%	Unkown
HY-RS10432	PHGDH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10433	Phgdh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-125273	DNS-pE	Inhibitor	/	Unkown
HY-126278	Z1609609733	Inhibitor	/	Unkown
HY-145860	PHGDH-IN-2		/	Unkown
HY-179652	PHGDH-IN-6	Inhibitor	/	Unkown
HY-184416	GDD-261		/	Unkown
HY-184449	PHGDH-IN-7		/	Unkown
HY-RS10434	Phgdh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-101966R	NCT-503 (Standard)		/	Unkown
HY-160252	PHGDH-IN-4	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Phgdh	NCBI	NCBI:26227