Gls - glutaminase Gene

Also Known as Glut; RATGLUT

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24398

About Gls

Primary_assembly 9: 49,344,781-49,416,900 forward strand.mRatBN7.2:CM026982.1

This gene has 3 transcripts (splice variants), 305 orthologues, 1 paralogue and is associated with 9 phenotypes. Biased expression in Kidney (RPKM 45.8), Brain (RPKM 295.5) and 9 other tissues.

Summary

Predicted to enable Glutaminase activity and identical protein binding activity. Predicted to be involved in glutamate homeostasis; glutamine family amino acid metabolic process; and protein homotetramerization. Predicted to act upstream of or within chemical synaptic transmission; regulation of respiratory gaseous exchange by nervous system process; and suckling behavior. Located in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to human GLS (Glutaminase). [provided by Alliance of Genome Resources, Apr 2022]

Gls Products (2)

mRNA Protein Name
NM_001109968.3 NP_001103438.2 glutaminase kidney isoform, mitochondrial isoform b
NM_012569.4 NP_036701.3 glutaminase kidney isoform, mitochondrial isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16899818 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gls Protein Structure

EF-hand_14

EF-hand_14: pfam17959 (142 - 225)

Glutaminase

Glutaminase: pfam04960 (247 - 531)

Ank_2

Ank_2: pfam12796 (560 - 652)

ANK

ANK: sd00045 (560 - 586)

ANK

ANK: sd00045 (588 - 620)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
Protein Preferred Names Protein Names

glutaminase kidney isoform, mitochondrial

  • K-glutaminase

  • L-glutamine amidohydrolase

  • kidney-type glutaminase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-12248 Telaglenastat 99.82% Phase 2
HY-108917 Morphothiadin Inhibitor 99.79% Phase 2
HY-128357 Ibezapolstat Inhibitor 98.0% Phase 2
HY-12248A Telaglenastat hydrochloride 98.03% Phase 2
HY-P2760 Glutaminase Control / Phase 2
HY-108917A Morphothiadin mesylate Inhibitor / Phase 2
HY-128357A Ibezapolstat hydrochloride Inhibitor / Phase 2
HY-103671 IPN60090 Inhibitor 98.96% Phase 1
HY-103671A IPN60090 dihydrochloride Inhibitor 99.68% Phase 1
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99109 Zimberelimab Inhibitor 99.90% Phase 3

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150109A Purinostat Inhibitor 98.04% Unkown
HY-136704 GLS1 Inhibitor-1 Inhibitor 98.59% Unkown
HY-79583 Glutaminase-IN-3 Inhibitor 99.88% Unkown
HY-144666 GLS-1-IN-1 Inhibitor 99.83% Unkown
HY-RS05500 GLS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-151434 GLS1 Inhibitor-6 / Unkown
HY-146616 GLS1 Inhibitor-3 Inhibitor / Unkown
HY-146617 GLS1 Inhibitor-4 / Unkown
HY-146658 Glutaminase-IN-4 Inhibitor / Unkown
HY-148241 A-446 Inhibitor / Unkown
HY-152207 LWG-301 / Unkown
HY-155138 GLS1 Inhibitor-7 Inhibitor / Unkown
HY-174211 JNK-IN-23 Inhibitor / Unkown
HY-179003 mTOR/GLS1-IN-1 / Unkown
HY-181890 TRG-192 Inhibitor / Unkown
HY-RS05501 Gls Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05502 Gls Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05503 GLS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17808 Gls2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24276 Gls2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990976 Brivestobart 99.198% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gls NCBI NCBI:2744