Il3 - interleukin 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24495

About Il3

Primary_assembly 10: 38,405,716-38,408,066 reverse strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 42 orthologues and is associated with 29 phenotypes. Low expression observed in reference dataset.

Summary

Enables cytokine activity and interleukin-3 receptor binding activity. Involved in several processes, including hemopoiesis; positive regulation of cell population proliferation; and regulation of cell growth. Located in extracellular space. Used to study osteosarcoma. Biomarker of prostatic hypertrophy and pyelonephritis. Human ortholog(s) of this gene implicated in Graves' disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3). [provided by Alliance of Genome Resources, Apr 2022]

Il3 Products (1)

mRNA Protein Name
NM_031513.2 NP_113701.2 interleukin-3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
3263940 RGD
enables cytokine activity IMP
IMP: Inferred from mutant phenotype
3086845 RGD
enables interleukin-3 receptor binding IMP
IMP: Inferred from mutant phenotype
3086845 RGD
Biological Process GO Annotation Evidence References Source
involved in hemopoiesis IMP
IMP: Inferred from mutant phenotype
9573350 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
3263940 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
9573350 RGD
involved in regulation of cell growth IMP
IMP: Inferred from mutant phenotype
3086845 RGD
involved in response to hormone IMP
IMP: Inferred from mutant phenotype
3086845 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
9573350 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il3 Protein Structure

IL3

IL3: pfam02059 (33 - 139)

  • 0
  • 100
  • 166 a.a.
Protein Preferred Names Protein Names

interleukin-3

  • IL-3

  • MCGF

  • P-cell-stimulating factor

  • hematopoietic growth factor

  • mast cell growth factor

  • multipotential colony-stimulating factor

Recombinant Il3 Proteins

Cat. No. Product Name Accession Purity
HY-P73208 IL-3 Protein, Rat (sf9, His) P97688 (I27-C169) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1402 Hydrocortisone hemisuccinate Inhibitor 99.83% Unkown
HY-B1402B Hydrocortisone hemisuccinate sodium Inhibitor 99.66% Unkown
HY-B1402A Hydrocortisone hemisuccinate hydrate Inhibitor 96.42% Unkown
HY-B1402R Hydrocortisone hemisuccinate (Standard) 99.67% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-113271 5-Androstenetriol Activator / Phase 4
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P99395 Talacotuzumab Inhibitor 98.82% Phase 3
HY-P990905 Bexatamig Inhibitor 97.06% Phase 2
HY-P99234 Pivekimab Inhibitor 97.19% Phase 1
HY-P991282 KHK2823 Inhibitor / Phase 1
HY-P991648 CSL-360 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126619 Aspochalasin D 95.0% Unkown
HY-164393 ON044580 99.11% Unkown
HY-P1111 Lyn peptide inhibitor Inhibitor 99.35% Unkown
HY-RS06764 IL3RA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-112378 D-65476 Inhibitor / Unkown
HY-121874 EP009 Inhibitor / Unkown
HY-155951 JAK3-IN-14 Inhibitor 99.10% Unkown
HY-168444 CDK4/6-IN-23 Inhibitor / Unkown
HY-B1402G Hydrocortisone hemisuccinate (GMP) Inhibitor / Unkown
HY-P1111A Lyn peptide inhibitor TFA Inhibitor / Unkown
HY-RS06751 IL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06752 Il3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06753 Il3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-14271 Acreozast / Unkown
HY-174605 Human IL3RA mRNA / Unkown
HY-174610 Human IL3 mRNA / Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990094 Trabikibart 99.17% Unkown
HY-P990214 Anti-Mouse IL-3 Antibody (MP2-8F8) Inhibitor 95.00% Unkown
HY-P991699 Lixarkitug Inhibitor 99% Unkown
HY-P990451 Anti-IL-3Ra/CD123 Antibody (SNG-CD123A) Inhibitor 95.01% Unkown
HY-P992032 TPP-9476 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il3 NCBI NCBI:3562