Anti-Mouse IL-3 Antibody (MP2-8F8)
Based on 1 Customer Validation
Anti-Mouse IL-3 Antibody (MP2-8F8) is an anti-mouse IL-3 IgG1 monoclonal antibody. Anti-Mouse IL-3 Antibody (MP2-8F8) relieves joint inflammation by reducing synovial leukocyte infiltration and cytokine levels. Anti-Mouse IL-3 Antibody (MP2-8F8) can reduce the accumulation of basophils. Anti-Mouse IL-3 Antibody (MP2-8F8) can be used for researches on inflammation or infection conditions such as arthritis and parasitic infections.
For research use only. We do not sell to patients.
- Purity: 95.00%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
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Biological Activity
Rat IgG1
Mouse
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IL-3 |
Anti-Mouse IL-3 Antibody (MP2-8F8) (2 mg, i.p., once every 3 days) reduces the accumulation of basophils in the liver after infection in Rag2-/- mice with a parasitic infection model[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CII (100-200 μg) induced male DBA/1 mice[1]
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Dosage:35 μg for early blockade, 50 for late blockade
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Administration:Intraperitoneal injection (i.p.), once daily, 15 days for early blockade or 7 days for late blockade
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Result:Significantly reduced the score of arthritis, synovitis, and antibody titers for early blockade.
Had no significant impact on arthritis for late blockade.
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Animal Model:Rag2-/- mice injected with 600 third stage infectious larvae of Nippostrongylus brasiliensis[3]
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Dosage:2 mg
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Administration:Intraperitoneal injection (i.p.), once every 3 days
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Result:Reduced eosinophils to 14 %.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo IL-3 neutralization; in vitro IL-3 neutralization; in vivo IL-3 receptor stimulation (as a
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse IL-3 Antibody (MP2-8F8)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Brühl H, et al. Important role of interleukin-3 in the early phase of collagen-induced arthritis. Arthritis Rheum. 2009 May;60(5):1352-61. [Content Brief]
[2]. Drube S, et al. IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt+ Treg generation via enhanced IL-6 induction. Immunology. 2021 May;163(1):86-97. [Content Brief]
[3]. Min B, et al. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J Exp Med. 2004 Aug 16;200(4):507-17. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse IL-3 Antibody (MP2-8F8) Related Classifications
HY-P990214 Related Classifications
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