Il3 - interleukin 3 Gene

Also Known as BPA; PSF; HCGF; Il-3; MCGF; Csfmu

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16187

About Il3

Chromosome 11: 54,156,129-54,158,103 reverse strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 42 orthologues and is associated with 10 phenotypes.

Summary

Enables cytokine activity; growth factor activity; and interleukin-3 receptor binding activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; monocyte differentiation; and regulation of phosphate metabolic process. Located in extracellular space. Is expressed in skin; stomach; thymus; and vascular system. Human ortholog(s) of this gene implicated in Graves' disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3). [provided by Alliance of Genome Resources, Apr 2022]

Il3 Products (1)

mRNA Protein Name
NM_010556.4 NP_034686.2 interleukin-3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
1350248 MGI
enables growth factor activity IDA
IDA: Inferred from direct assay
7957045 MGI
enables interleukin-3 receptor binding IPI
IPI: Inferred from physical interaction
19109256 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of B cell apoptotic process IDA
IDA: Inferred from direct assay
7736574 MGI
acts upstream of B cell proliferation IDA
IDA: Inferred from direct assay
7736574 MGI
acts upstream of JNK cascade IDA
IDA: Inferred from direct assay
14967141 MGI
acts upstream of JNK cascade IMP
IMP: Inferred from mutant phenotype
14967141 MGI
acts upstream of T cell proliferation IDA
IDA: Inferred from direct assay
12714518 MGI
acts upstream of or within activation of Janus kinase activity IDA
IDA: Inferred from direct assay
8378315 MGI
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
1350248 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
7690439 MGI
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
7519779 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: Inferred from direct assay
11527400 MGI
acts upstream of hematopoietic progenitor cell differentiation IGI
IGI: Inferred from genetic interaction
1375116 MGI
acts upstream of or within interleukin-3-mediated signaling pathway IDA
IDA: Inferred from direct assay
19109256 MGI
acts upstream of mast cell apoptotic process IDA
IDA: Inferred from direct assay
12714518 MGI
acts upstream of mast cell proliferation IDA
IDA: Inferred from direct assay
12714518 MGI
acts upstream of or within monocyte differentiation IGI
IGI: Inferred from genetic interaction
19109256 MGI
acts upstream of myeloid cell apoptotic process IDA
IDA: Inferred from direct assay
10652277 MGI
acts upstream of or within myeloid cell apoptotic process IDA
IDA: Inferred from direct assay
9202146 MGI
acts upstream of myeloid leukocyte differentiation IGI
IGI: Inferred from genetic interaction
1375116 MGI
acts upstream of or within negative regulation of B cell apoptotic process IDA
IDA: Inferred from direct assay
7736574 MGI
acts upstream of or within negative regulation of autophagy IDA
IDA: Inferred from direct assay
15680329 MGI
acts upstream of or within negative regulation of mast cell apoptotic process IDA
IDA: Inferred from direct assay
12714518 MGI
acts upstream of or within negative regulation of myeloid cell apoptotic process IDA
IDA: Inferred from direct assay
10652277 MGI
acts upstream of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
10872802 MGI
acts upstream of or within positive regulation of B cell proliferation IDA
IDA: Inferred from direct assay
7736574 MGI
acts upstream of or within positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
14967141 MGI
acts upstream of or within positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
14967141 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
12714518 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
1350248 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
7690439 MGI
acts upstream of or within positive regulation of hematopoietic progenitor cell differentiation IGI
IGI: Inferred from genetic interaction
1375116 MGI
acts upstream of or within positive regulation of mast cell proliferation IDA
IDA: Inferred from direct assay
12714518 MGI
acts upstream of or within positive regulation of myeloid leukocyte differentiation IGI
IGI: Inferred from genetic interaction
1375116 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
7519779 MGI
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
14967141 MGI
acts upstream of or within protein dephosphorylation IDA
IDA: Inferred from direct assay
12944463 MGI
acts upstream of protein phosphorylation IDA
IDA: Inferred from direct assay
14967141 MGI
acts upstream of or within regulation of cell growth IGI
IGI: Inferred from genetic interaction
19109256 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
9697835 MGI
acts upstream of or within regulation of glycolytic process IGI
IGI: Inferred from genetic interaction
17437992 MGI
acts upstream of or within response to hypoxia IGI
IGI: Inferred from genetic interaction
17437992 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
7690439 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il3 Protein Structure

IL3

IL3: pfam02059 (34 - 137)

  • 0
  • 100
  • 166 a.a.
Protein Preferred Names Protein Names

interleukin-3

  • P-cell-stimulating factor

  • hematopoietic growth factor

  • mast cell growth factor

  • multipotential colony-stimulating factor

Recombinant Il3 Proteins

Cat. No. Product Name Accession Purity
HY-P7062A IL-3 Protein, Mouse (His) P01586 (D33-C166) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7062 IL-3 Protein, Mouse P01586 (D33-C166) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70685 IL-3 Protein, Mouse (HEK293, His) P01586 (A27-C166) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73207 IL-3 Protein, Mouse (HEK293) P01586 (A27-C166)/NP_034686.2 ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78313 IL-3 Protein, Mouse (HEK293, Fc) P01586 (A27-C166) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700205AF Animal-Free IL-3 Protein, Mouse (His) P01586 (D33-C166) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1402 Hydrocortisone hemisuccinate Inhibitor 99.83% Unkown
HY-B1402B Hydrocortisone hemisuccinate sodium Inhibitor 99.66% Unkown
HY-B1402A Hydrocortisone hemisuccinate hydrate Inhibitor 96.42% Unkown
HY-B1402R Hydrocortisone hemisuccinate (Standard) 99.67% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-113271 5-Androstenetriol Activator / Phase 4
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P99395 Talacotuzumab Inhibitor 98.82% Phase 3
HY-P990905 Bexatamig Inhibitor 97.06% Phase 2
HY-P99234 Pivekimab Inhibitor 97.19% Phase 1
HY-P991282 KHK2823 Inhibitor / Phase 1
HY-P991648 CSL-360 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126619 Aspochalasin D 95.0% Unkown
HY-164393 ON044580 99.11% Unkown
HY-P1111 Lyn peptide inhibitor Inhibitor 99.35% Unkown
HY-RS06764 IL3RA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-112378 D-65476 Inhibitor / Unkown
HY-121874 EP009 Inhibitor / Unkown
HY-155951 JAK3-IN-14 Inhibitor 99.10% Unkown
HY-168444 CDK4/6-IN-23 Inhibitor / Unkown
HY-B1402G Hydrocortisone hemisuccinate (GMP) Inhibitor / Unkown
HY-P1111A Lyn peptide inhibitor TFA Inhibitor / Unkown
HY-RS06751 IL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06752 Il3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06753 Il3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-14271 Acreozast / Unkown
HY-174605 Human IL3RA mRNA / Unkown
HY-174610 Human IL3 mRNA / Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990094 Trabikibart 99.17% Unkown
HY-P990214 Anti-Mouse IL-3 Antibody (MP2-8F8) Inhibitor 95.00% Unkown
HY-P991699 Lixarkitug Inhibitor 99% Unkown
HY-P990451 Anti-IL-3Ra/CD123 Antibody (SNG-CD123A) Inhibitor 95.01% Unkown
HY-P992032 TPP-9476 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il3 NCBI NCBI:3562