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PDGFRA - platelet derived growth factor receptor alpha Gene

Also Known as APDGFR; PDGFACE

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25267

About PDGFRA

Primary_assembly 14: 33,005,839-33,054,335 reverse strand.mRatBN7.2:CM026987.1

This gene has 2 transcripts (splice variants), 204 orthologues, 54 paralogues and is associated with 53 phenotypes. Biased expression in Uterus (RPKM 247.4), Kidney (RPKM 24.5) and 9 other tissues.

Summary

Enables phosphatidylinositol 3-kinase binding activity and platelet-derived growth factor alpha-receptor activity. Involved in several processes, including animal organ development; cellular response to interleukin-1; and positive regulation of branching involved in lung morphogenesis. Located in several cellular components, including axon; nucleus; and plasma membrane. Used to study middle cerebral artery infarction. Biomarker of chronic ulcer of skin; hypertension; oligohydramnios; pulmonary fibrosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in hematologic Cancer (multiple); hypereosinophilic syndrome; and pancreatic Cancer. Orthologous to human PDGFRA (platelet derived growth factor receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

PDGFRA Products (2)

mRNA	Protein	Name
NM_012802.1	NP_036934.1	platelet-derived growth factor receptor alpha precursor
NM_012802.1	NP_036934.1	platelet-derived growth factor receptor alpha precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylinositol 3-kinase binding	IPI IPI: Inferred from physical interaction	18421086	RGD
enables platelet-derived growth factor alpha-receptor activity	IDA IDA: Inferred from direct assay	2157969	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	14593115	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	7546776	RGD
involved in inner ear development	IEP IEP: Inferred from expression pattern	15267171	RGD
involved in lung growth	IMP IMP: Inferred from mutant phenotype	8879189	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	11870082	RGD
involved in positive regulation of branching involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	8879189	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15267171	RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	2157969	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	15155567	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	14724432	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	14724432	RGD
involved in response to formaldehyde	IEP IEP: Inferred from expression pattern	18045764	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	15534218	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	15722379	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	19909480	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	11788434	RGD
located in nucleus	IDA IDA: Inferred from direct assay	11788434	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	11788434	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDGFRA Protein Structure

Ig_3

Ig4_PDGFR

PTKc_PDGFR_alpha

0
200
400
600
800
1000
1088 a.a.

Protein Preferred Names	Protein Names
platelet-derived growth factor receptor alpha	CD140 antigen-like family member A PDGF-R-alpha PDGFR-alpha alpha platelet-derived growth factor receptor alpha-type platelet-derived growth factor receptor platelet derived growth factor receptor, alpha polypeptide platelet-derived growth factor alpha receptor platelet-derived growth factor receptor alpha-like

Recombinant PDGFRA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73721	PDGFRA Protein, Rat (HEK293, His)	P20786 (L24-E523)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73722	PDGFRA Protein, Rat (HEK293, Fc)	G3V6A0 (L24-E523)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13001	Quizartinib		99.08%	Yes
HY-101561	Avapritinib	Inhibitor	99.85%	Yes
HY-112306	Ripretinib		98.90%	Yes
HY-14217	Quizartinib dihydrochloride		99.81%	Unkown
HY-13001R	Quizartinib (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132166	Velzatinib	Inhibitor	99.40%	Phase 3

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10254	PDGFRA Human Pre-designed siRNA Set A		/	Unkown
HY-108444	(Z)-FeCP-oxindole	Inhibitor	99.62%	Unkown
HY-13001S	Quizartinib-d8		/	Unkown
HY-108444A	(E)-FeCP-oxindole	Inhibitor	/	Unkown
HY-149510	MET/PDGFRA-IN-1		/	Unkown
HY-149511	MET/PDGFRA-IN-2		/	Unkown
HY-170911	KIT/PDGFRA-IN-1	Inhibitor	/	Unkown
HY-173124	CDK2/FLT4/PDGFRA-IN-1		/	Unkown
HY-175212	PDGFRA-IN-1	Inhibitor	/	Unkown
HY-181108	GSK190937	Inhibitor	/	Unkown
HY-181587	PDGFRA/CAIX/XII-IN-1		98.10%	Unkown
HY-181886	AK177		/	Unkown
HY-RS10255	Pdgfra Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS10256	PDGFRA Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174549	Human PDGFRA mRNA		/	Unkown
HY-W754911	Avapritinib-d3	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	PDGFRA	NCBI	NCBI:5156