Mip - major intrinsic protein of lens fiber Gene

Also Known as Aqp0

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25480

Summary

Enables water channel activity. Involved in canalicular bile acid transport and water transport. Located in intracellular canaliculus and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in cataract and cataract 15 multiple types. Orthologous to human MIP (major intrinsic protein of lens fiber). [provided by Alliance of Genome Resources, Apr 2022]

Mip Products (1)

mRNA Protein Name
NM_001105719.2 NP_001099189.1 lens fiber major intrinsic protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables water channel activity IDA
IDA: Inferred from direct assay
11932260 RGD
Biological Process GO Annotation Evidence References Source
involved in canalicular bile acid transport IDA
IDA: Inferred from direct assay
11932260 RGD
involved in water transport IDA
IDA: Inferred from direct assay
11932260 RGD
Cellular Component GO Annotation Evidence References Source
located in intracellular canaliculus IDA
IDA: Inferred from direct assay
11932260 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lens fiber major intrinsic protein

  • MIP26

  • MP26

  • aquaporin-0

  • major intrinsic protein of eye lens fiber

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1829A Dexamethasone phosphate disodium 99.94% Yes
HY-B1829AR Dexamethasone phosphate disodium (Standard) 99.88% Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-B0498 Bindarit Inhibitor 99.59% Phase 3
HY-B0155 Vicriviroc / Phase 3
HY-118962 E913 / Phase 3
HY-19974 TAK-220 99.95% Phase 1
HY-P3627 Nagrestipen / Phase 1

Pre-clinical Phase

Bioactive Molecules (36)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156371 MIPS-21335 Inhibitor 99.61% Unkown
HY-139644 MIPS521 Agonist 98.21% Unkown
HY-P4191A Met-RANTES (human) acetate Antagonist 99.39% Unkown
HY-P5523A iE-DAP dihydrochloride 99.72% Unkown
HY-120265 MIPS-9922 Inhibitor 99.25% Unkown
HY-123733A MIP-1095 TFA Inhibitor 99.76% Unkown
HY-149650 TLR4 agonist-1 Agonist / Unkown
HY-161901 BC-1293 Inhibitor 98.40% Unkown
HY-N10116A Calamenene / Unkown
HY-P4191 Met-RANTES (human) Antagonist / Unkown
HY-W014081 Ethyl 3-coumarincarboxylate 99.81% Unkown
HY-B1829 Dexamethasone phosphate 98.89% Yes
HY-110391 BX-513 Antagonist / Unkown
HY-123661 MIPS1455 / Unkown
HY-123733 MIP-1095 Inhibitor / Unkown
HY-129615 MIP-1072 Inhibitor / Unkown
HY-149650A TLR4 agonist-1 TEA Agonist / Unkown
HY-149861 Mip-IN-1 Inhibitor / Unkown
HY-15544 CCR1 antagonist 10 Antagonist / Unkown
HY-179277 MIPS3526 Agonist / Unkown
HY-B0155B Vicriviroc malate / Unkown
HY-P11093 Papiliocin / Unkown
HY-P11502 COG112 Inhibitor / Unkown
HY-P5523 iE-DAP / Unkown
HY-RS08460 MIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08461 MIPEP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14859 TNPO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-103360B trans-J-113863 Antagonist / Unkown
HY-168149 Mip-IN-2 Inhibitor / Unkown
HY-174744 Human CCR4 mRNA / Unkown
HY-B1829R Dexamethasone phosphate (Standard) / Unkown
HY-N10175 Berkeleyacetal C / Unkown
HY-RS19300 Mip Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20118 Tnpo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22639 Mipep Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25791 Mip Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mip NCBI NCBI:4284
Mus musculus Mip NCBI NCBI:17339
Macaca mulatta Mip NCBI NCBI:712901