Ptpn11 - protein tyrosine phosphatase, non-receptor type 11 Gene

Also Known as Shp2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25622

Summary

Enables several functions, including Insulin Receptor substrate binding activity; Phospholipase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to peptide hormone stimulus; and positive regulation of focal adhesion assembly. Located in cytosol; mitochondrion; and plasma membrane raft. Part of protein-containing complex. Used to study glaucoma. Biomarker of glaucoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine Phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn11 Products (2)

mRNA Protein Name
NM_001177593.1 NP_001171064.1 tyrosine-protein phosphatase non-receptor type 11 isoform 1
NM_013088.2 NP_037220.2 tyrosine-protein phosphatase non-receptor type 11 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables D1 dopamine receptor binding IPI
IPI: Inferred from physical interaction
23328768 RGD
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
9388260 RGD
enables insulin receptor binding IDA
IDA: Inferred from direct assay
7711057 RGD
enables insulin receptor substrate binding IPI
IPI: Inferred from physical interaction
12891559 RGD
enables phospholipase binding IDA
IDA: Inferred from direct assay
16814162 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7545675 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
10973965 RGD
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
16690621 RGD
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
7512964 RGD
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
15115663 RGD
Biological Process GO Annotation Evidence Références Source
involved in cellular response to angiotensin IEP
IEP: Inferred from expression pattern
9139682 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
19348936 RGD
involved in cellular response to insulin-like growth factor stimulus IEP
IEP: Inferred from expression pattern
9139682 RGD
involved in cellular response to mechanical stimulus IPI
IPI: Inferred from physical interaction
18757826 RGD
involved in positive regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
16905534 RGD
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
7711057 RGD
involved in smooth muscle cell proliferation IEP
IEP: Inferred from expression pattern
12117720 RGD
Cellular Component GO Annotation Evidence Références Source
located in plasma membrane raft IDA
IDA: Inferred from direct assay
19348936 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
10973965 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein phosphatase non-receptor type 11

  • PTP-1D

  • SH-PTP2 protein tyrosine phosphatase, non-receptor type 11

  • SHP-2

  • encodes catalytic domain

  • protein tyrosine phosphatase SH-PTP2

  • protein-tyrosine phosphatase 1D

  • protein-tyrosine phosphatase SYP

Ptpn11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Cross
Ptpn11 P41499 PDGFRB Homo sapiens P09619
Phosphatase Assay
7545675
Intra
Ptpn11 P41499 Sirpa Rattus norvegicus P97710
Far-WB
8810330
Intra
Ptpn11 P41499 Jak2 Rattus norvegicus Q62689
Anti Bait CoIP
8912646
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-131132A JAB-3068 hydrochloride Inhibitor 98.88% Phase 2

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-101964 SPI-112 Inhibitor 98.01% Unkown
HY-131132 JAB-3068 Inhibitor 99.49% Unkown
HY-114460 SHP2-IN-1 Inhibitor ≥99.0% Unkown
HY-120159 GS-493 Inhibitor / Unkown
HY-125257 SHP2 inhibitor LY6 / Unkown
HY-125259 SHP504 Inhibitor / Unkown
HY-RS11416 PTPN11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16733 Ptpn11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23169 Ptpn11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptpn11 NCBI NCBI:5781