2. Gene
  3. Jak2 - Janus kinase 2 Gene

Jak2 - Janus kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 24514 | Gene type: protein coding

About Jak2

Primary_assembly 1: 226,995,334-227,054,189 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 265 orthologues, 32 paralogues and is associated with 95 phenotypes. Biased expression in Thymus (RPKM 325.), Spleen (RPKM 258.4) and 9 other tissues.

Summary

Enables several functions, including Insulin Receptor substrate binding activity; protein C-terminus binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of protein transport; and regulation of apoptotic process. Located in cytosol; euchromatin; and nucleolus. Is active in glutamatergic synapse and postsynapse. Used to study several diseases, including hyperuricemia; liver disease (multiple); non-alcoholic fatty liver disease; retinal detachment; and thrombocytosis. Biomarker of gastrointestinal system Cancer (multiple); heart disease; liver cirrhosis; and obesity. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Jak2 Products(1)

mRNA Protein Name
NM_031514.1 NP_113702.1 tyrosine-protein kinase JAK2

Jak2 Protein Structure

FERM_F1

FERM_F1: pfam18379 (38 - 133)

FERM_F2

FERM_F2: pfam18377 (142 - 260)

FERM_C_JAK2

FERM_C_JAK2: cd13333 (265 - 385)

SH2_Jak2

SH2_Jak2: cd10379 (385 - 481)

PTK_Jak2_rpt1

PTK_Jak2_rpt1: cd05078 (544 - 805)

PTKc_Jak2_rpt2

PTKc_Jak2_rpt2: cd14205 (843 - 1126)

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  • 1132 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase JAK2

JAK-2

Janus kinase 2 (a protein tyrosine kinase)

Related Agents

Approval
Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50856 Ruxolitinib Inhibitor 99.99% Yes
HY-40354 Tofacitinib Inhibitor 99.99% Yes
HY-15315 Baricitinib Inhibitor 99.97% Yes
HY-19569 Upadacitinib Inhibitor 99.98% Yes
HY-10409 Fedratinib Inhibitor 99.87% Yes
HY-50858 Ruxolitinib phosphate Inhibitor 99.98% Yes
HY-16379 Pacritinib Inhibitor 99.93% Yes
HY-40354A Tofacitinib citrate Inhibitor 99.98% Yes
HY-18300 Filgotinib Inhibitor 99.68% Yes
HY-107429 Abrocitinib Inhibitor 99.26% Unkown
HY-19568 Peficitinib Inhibitor 99.43% Yes
HY-15315A Baricitinib phosphate Inhibitor 99.91% Yes
HY-109053 Delgocitinib Inhibitor 99.87% Unkown
HY-10409A Fedratinib hydrochloride hydrate Inhibitor 99.89% Yes
HY-13577A Oclacitinib maleate Inhibitor 99.63% Unkown
HY-13577 Oclacitinib Inhibitor 99.23% Unkown
HY-19569A Upadacitinib tartrate tetrahydrate Inhibitor / Unkown
HY-16379A Pacritinib hydrochloride Inhibitor / Unkown
HY-18300A Filgotinib maleate Inhibitor / Unkown
HY-50859 Ruxolitinib sulfate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Phase
HY-10961 Momelotinib Inhibitor 99.37% Phase 3
HY-15999 Cerdulatinib Inhibitor 98.96% Phase 3
HY-12469 Decernotinib Inhibitor 99.67% Phase 3
HY-50867 Lestaurtinib Inhibitor 99.17% Phase 3
HY-10962 Momelotinib sulfate Inhibitor 98.06% Phase 3
HY-112724 Ivarmacitinib Inhibitor 99.82% Phase 3
HY-15999A Cerdulatinib hydrochloride Inhibitor 99.89% Phase 3
HY-50856S Deuruxolitinib Inhibitor 99.18% Phase 3
HY-10963 Momelotinib Mesylate Inhibitor / Phase 3
HY-50514 AT9283 Inhibitor 99.70% Phase 2
HY-13034 Gandotinib Inhibitor 99.82% Phase 2
HY-15270 BMS-911543 Inhibitor 98.53% Phase 2
HY-112708A Brepocitinib P-Tosylate Inhibitor 99.86% Phase 2
HY-19631A Ilginatinib Inhibitor 99.53% Phase 2
HY-112708 Brepocitinib Inhibitor 98.64% Phase 2
HY-109179 Itacnosertib Inhibitor 99.77% Phase 2
HY-19631B Ilginatinib hydrochloride Inhibitor ≥98.0% Phase 2
HY-19631 Ilginatinib maleate Inhibitor 99.87% Phase 2
HY-15312 WP1066 Inhibitor 99.77% Phase 1
HY-10193 AZD-1480 Inhibitor 99.56% Phase 1
HY-13775 XL019 Inhibitor ≥98.0% Phase 1
HY-15504 RGB-286638 Inhibitor 99.84% Phase 1
HY-112809 GSK2646264 Inhibitor 98.39% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.07% Phase 1
Pre-clinical Phase
Bioactive Molecules (69)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148748 Butyzamide Activator 99.62% Unkown
HY-18960 CHZ868 Inhibitor 99.56% Unkown
HY-N1405 Cucurbitacin I Inhibitor 99.44% Unkown
HY-15166 (E/Z)-Zotiraciclib Inhibitor 99.96% Unkown
HY-14435 Pyridone 6 Inhibitor 98.13% Unkown
HY-10410 TG101209 Inhibitor 99.22% Unkown
HY-15343 CEP-33779 Inhibitor 99.23% Unkown
HY-10411 AZ960 Inhibitor 97.15% Unkown
HY-15480 NSC 42834 Inhibitor 98.01% Unkown
HY-100895 SAR-20347 Inhibitor 97.12% Unkown
HY-N2963 Broussonin E Activator 98.18% Unkown
HY-145696 SJ10542 Inhibitor 99.92% Unkown
HY-137756 JAK2-IN-6 Inhibitor 99.14% Unkown
HY-14722 NVP-BSK805 Inhibitor 99.89% Unkown
HY-14722A NVP-BSK805 dihydrochloride Inhibitor 99.36% Unkown
HY-N1356 Reticuline Inhibitor 98.91% Unkown
HY-151262 JAK-IN-23 Inhibitor 98.90% Unkown
HY-130247 JAK2/FLT3-IN-1 Inhibitor 99.79% Unkown
HY-113573 Protosappanin A 99.98% Unkown
HY-151902 SJ988497 Inhibitor 98.05% Unkown
HY-131906 JAK2-IN-7 Inhibitor 99.15% Unkown
HY-130247A JAK2/FLT3-IN-1 TFA Inhibitor 99.77% Unkown
HY-146186 JAK2 JH2 binder-1 Modulator 95.47% Unkown
HY-108264 TCS 21311 Inhibitor 99.18% Unkown
HY-15166B (E/Z)-Zotiraciclib citrate Inhibitor 98.06% Unkown
HY-139423 JAK1-IN-8 Inhibitor ≥95.0% Unkown
HY-15166A (E/Z)-Zotiraciclib hydrochloride Inhibitor 99.45% Unkown
HY-120469 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Inhibitor 98.78% Unkown
HY-124858 SC99 Inhibitor 98.96% Unkown
HY-19544 JAK3-IN-1 Inhibitor 99.23% Unkown
HY-147330B SJ1008030 formic Inhibitor 97.66% Unkown
HY-147330A SJ1008030 TFA Inhibitor 99.81% Unkown
HY-115452 G5-7 Inhibitor 99.55% Unkown
HY-13961 GLPG0634 analog Inhibitor 98.58% Unkown
HY-116505 JAK1-IN-4 Inhibitor / Unkown
HY-111750 JAK-IN-3 Inhibitor 98.92% Unkown
HY-112391 SD-1029 Inhibitor / Unkown
HY-152080 TUL01101 Inhibitor / Unkown
HY-14722C NVP-BSK805 trihydrochloride Inhibitor / Unkown
HY-155951 JAK3-IN-14 Inhibitor 99.32% Unkown
HY-154994 JAK-IN-30 Inhibitor / Unkown
HY-161139 JAK1-IN-14 Inhibitor / Unkown
HY-151259 TK4b Inhibitor / Unkown
HY-149296 JAK1-IN-12 Inhibitor / Unkown
HY-151258 TK4g Inhibitor / Unkown
HY-143444 JAK-IN-20 Inhibitor / Unkown
HY-143885 JAK1/TYK2-IN-3 Inhibitor / Unkown
HY-155746 JAK2-IN-9 Inhibitor / Unkown
HY-147975 JAK3-IN-12 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-10652 JAK-2/3-IN-1 Inhibitor / Unkown
HY-148060 JAK-IN-21 Inhibitor 99.72% Unkown
HY-155785 MTP Inhibitor / Unkown
HY-146727 JAK3-IN-11 Inhibitor / Unkown
HY-100849 JAK 3i Inhibitor / Unkown
HY-150720 TYK2-IN-12 Inhibitor / Unkown
HY-157121 JAK-IN-34 Inhibitor / Unkown
HY-143884 JAK2/TYK2-IN-1 Inhibitor / Unkown
HY-124727 ZT55 Inhibitor / Unkown
HY-108342 PF-00956980 Inhibitor / Unkown
HY-18293 NSC 33994 Inhibitor / Unkown
HY-147754 JAK3/BTK-IN-6 Inhibitor / Unkown
HY-151285 JAK-2/3-IN-3 Inhibitor / Unkown
HY-151256 JAK-2/3-IN-2 Inhibitor / Unkown
HY-144440 JAK1-IN-9 Inhibitor / Unkown
HY-153440 JAK-IN-25 Inhibitor 98.44% Unkown
HY-162248 JAK1/2-IN-1 Inhibitor / Unkown
HY-10058 AT9283 lactic acid Inhibitor / Unkown
HY-107595 SD-1008 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jak2 NCBI NCBI:3717