SB1578
SB1578 (CT-1578) is a selective JAK2 and FLT3 inhibitor with an IC50 of 46 nM and 60 nM, respectively. SB1578 exhibits high selectivity for other kinase targets. SB1578 can be used for the study of non-oncology indication rheumatoid arthritis.
For research use only. We do not sell to patients.
- CAS No.: 937273-04-6
- Formula: C26H30N4O4
- Molecular Weight:462.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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JAK2 46 nM (IC50) |
FLT3 60 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SET-2 | IC50 |
0.246 nM
Compound: 14l, SB1578, 67:33 trans/Cis mixture
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Antiproliferative activity against human SET2 cells expressing JAK2 V617F mutan
Antiproliferative activity against human SET2 cells expressing JAK2 V617F mutan
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[PMID: 22339472] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 937273-04-6
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Molecular Weight 462.54
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Formula C26H30N4O4
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SMILES
N1(CCCC1)CCOC2=CC=C3C=C2COC/C=C/COCC4=CC=C(O4)C5=CC=N/C(N5)=N/3
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Synonyms
CT-1578
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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