1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. JAK2-IN-6

JAK2-IN-6 

Cat. No.: HY-137756
Handling Instructions

JAK2-IN-6, a multiple-substituted aminothiazole derivative, is a potent and selective JAK2 inhibitor with an IC50 of 22.86 μg/mL. JAK2-IN-6 shows no activity against JAK1 and JAK3. JAK2-IN-6 has anti-proliferative effect against cancer cells.

For research use only. We do not sell to patients.

JAK2-IN-6 Chemical Structure

JAK2-IN-6 Chemical Structure

CAS No. : 353512-04-6

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Description

JAK2-IN-6, a multiple-substituted aminothiazole derivative, is a potent and selective JAK2 inhibitor with an IC50 of 22.86 μg/mL. JAK2-IN-6 shows no activity against JAK1 and JAK3. JAK2-IN-6 has anti-proliferative effect against cancer cells[1].

IC50 & Target[1]

JAK2

22.86 μg/mL (IC50)

In Vitro

JAK2-IN-6 (Compound B2; 6.3-50 μg/mL; 48 hours; PC-9, H1975 and PANC-1 cells) treatment exhibits significantly antiproliferative activity against all of these cancer cell lines, with IC50 values of 18.1 μg/mL, 58.3 μg/mL, 40.6 μg/mL against PC-9, H1975 and PANC-1, respectively[1].
JAK2-IN-6 (Compound B2), an intramolecular hydrogen bond is formed, holding the chlorothiophene substituent coplanar with the aminothiazole core. The chlorothiophene moiety is found to be located in the binding pocket adjacent to Val863 and Leu983, and extends towards the Asp994 of activation loop and the Gly993 of glycine-rich loop[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: PC-9, H1975 and PANC-1 cells
Concentration: 6.3 μg/mL, 12.5 μg/mL, 25 μg/mL, 50 μg/mL
Incubation Time: 48 hours
Result: Exhibited significantly antiproliferative activity against all of these cancer cell lines.
Molecular Weight

335.83

Formula

C₁₄H₁₀ClN₃OS₂

CAS No.

353512-04-6

SMILES

O=C(C1=C(N)N=C(NC2=CC=CC=C2)S1)C3=CC=C(Cl)S3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

JAK2-IN-6JAKJanus kinaseJAK2anti-canceranti-proliferativeglycine-richaminothiazoleInhibitorinhibitorinhibit

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JAK2-IN-6
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HY-137756
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