JAK2-IN-23
JAK2-IN-23 is a highly selective JH2-binding JAK2 inhibitor, with an IC50 ≤ 10 nM for binding to both wild-type and V617F-mutated JH2. JAK2-IN-23 can be used in studies of JAK2-related diseases, such as cancer.
For research use only. We do not sell to patients.
- CAS No.: 3057053-16-1
- Formula: C25H27N7O4
- Molecular Weight:489.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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JAK2 JH2 |
JAK2-IN-23 (Example 5) exhibits an IC50 > 1000 nM for JH1 binding, an IC50 ≤ 10 nM for binding to wild-type and V617F-mutated JH2, and an IC50 ranging from 500 to 1000 nM for inhibiting the enzymatic activity of the V617F mutant[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3057053-16-1
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Molecular Weight 489.53
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Formula C25H27N7O4
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SMILES
O=C1N([C@H]2C[C@@H](CC2)NC(OC)=O)C3=CC(NC4=CC=CC(C5=CN=C(OC)C=C5)=N4)=NC=C3N1C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK2-IN-23 Related Classifications
HY-188002 Related Classifications
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