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Cat. No.: HY-188002

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JAK2-IN-23

JAK2-IN-23 is a highly selective JH2-binding JAK2 inhibitor, with an IC₅₀ ≤ 10 nM for binding to both wild-type and V617F-mutated JH2. JAK2-IN-23 can be used in studies of JAK2-related diseases, such as cancer.

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CAS No.: 3057053-16-1
Formule: C₂₅H₂₇N₇O₄
Masse moléculaire:489.53

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

JAK2-IN-23 Chemical Structure

CAS No.: 3057053-16-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

JAK2 JH2

Voir tous les produits spécifiques à Isoform JAK :

In Vitro

JAK2-IN-23 (Example 5) exhibits an IC₅₀ > 1000 nM for JH1 binding, an IC₅₀ ≤ 10 nM for binding to wild-type and V617F-mutated JH2, and an IC₅₀ ranging from 500 to 1000 nM for inhibiting the enzymatic activity of the V617F mutant^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3057053-16-1
Masse moléculaire 489.53
Formule C₂₅H₂₇N₇O₄
SMILES

O=C1N([C@H]2C[C@@H](CC2)NC(OC)=O)C3=CC(NC4=CC=CC(C5=CN=C(OC)C=C5)=N4)=NC=C3N1C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Li X, et al. Bicyclic ureas as kinase inhibitors. WO2024191996A1. WIPO. 2024.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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JAK2-IN-23

Voir tous les produits spécifiques à Isoform JAK

Activité biologique

Description

IC50 & Target

In Vitro

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

JAK2-IN-23 Related Classifications

HY-188002 Related Classifications

Bioz

Keywords

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