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Cat. No.: HY-188001

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JAK2-IN-22

JAK2-IN-22 is a bicyclic urea compound with potent binding inhibitory activity against wild-type and V617F mutant JH2 kinases (IC₅₀ ≤ 10 nM). JAK2-IN-22 can be used in research related to various diseases including cancer.

For research use only. We do not sell to patients.

CAS No.: 3057053-13-8
Formula: C₃₃H₃₄FN₇O₅
Molecular Weight:627.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

JAK2-IN-22 Chemical Structure

CAS No.: 3057053-13-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

JAK2^wt

JAK2^V617F

All JAK Isoforms :

In Vitro

JAK2-IN-22 (Example 2) exhibits potent binding inhibitory activity against wild-type/V617F mutant JH2 (IC₅₀ ≤ 10 nM), but shows almost no binding inhibitory effect on JH1 and no enzymatic inhibitory activity against V617F JAK2 (IC₅₀ > 1000 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 3057053-13-8
Molecular Weight 627.67
Formula C₃₃H₃₄FN₇O₅
SMILES

O=C1N([C@H]2C[C@@H](CC2)NC(OC)=O)C3=CC(NC4=CC(C5=CC(C#N)=CC=C5)=CC(NC(C6(CCOCC6)F)=O)=C4)=NC=C3N1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li X, et al. Bicyclic ureas as kinase inhibitors. WO2024191996A1. WIPO. 2024.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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