JAK-2/3-IN-3
Based on 1 Customer Validation
JAK-2-/3-IN-3 (compound ST4j) is a potent JAK2/3 inhibitor with IC50s of 13.00 and 14.86 nM for JAK2 and JAK3, respectively. JAK-2-/3-IN-3 inhibits autophosphorylation of JAK2 and induces apoptosis in a dose- and time-dependent manner. JAK-2-/3-IN-3 can be used in studies of lymph derived diseases and leukemia.
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- CAS No.: 2242031-31-6
- 화학식: C13H10Cl2N4O2
- 분자량:325.15
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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JAK2 13.00 nM (IC50) |
JAK3 14.86 nM (IC50) |
JAK-2/3-IN-3 (0-100 μM; 72 h) specifically inhibits human erythroleukemia cells with low toxicity to the normal cells[1].
JAK-2/3-IN-3 inhibits human erythroleukemia TF1 cell growth via the JAK2/STAT5 signaling pathway[1].
JAK-2/3-IN-3 (15.53 μM; 24, 48, 72 h) induces cytotoxicity via apoptosis in a time-dependent manner in TF1 cells[1].
JAK-2/3-IN-3 (IC25, IC50, IC75; 24 h) induces cytotoxicity via apoptosis in a dose-dependent manner in TF1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:TF1 cells
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Concentration:15.53 μM
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Incubation Time:24, 48, 72 h
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Result:Increased cells apoptotic by ∼20%, ∼40% and ∼70%, after 24-, 48- and 72-h incubations, respectively.
Increased cells apoptotic by ∼15%, 20%, and 30% with concentration of IC25, IC50 and IC75, respectively.
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Cell Line:TF1, HEL, Vero and HepG2 cells
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Concentration:0-100 μM
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Incubation Time:72 h
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Result:Inhibited growth of TF1 and HEL cells, with IC50s of 15.53 and 17.90 μM.
Showed low toxic to normal Vero cells and HepG2 cells (IC50 of >100 μM in Vero cells and of >50 μM in HepG2 cells).
Chemical Information
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CAS No. 2242031-31-6
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Appearance Solid
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분자량 325.15
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화학식 C13H10Cl2N4O2
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Color Light yellow to yellow
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SMILES
O=C1NC2=C(N=C1C3=C(N(C)N=C3C)O)C=C(Cl)C(Cl)=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 87.5 mg/mL (269.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (276 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0755 mL | 15.3775 mL | 30.7550 mL | 76.8876 mL |
| 5 mM | 0.6151 mL | 3.0755 mL | 6.1510 mL | 15.3775 mL | |
| 10 mM | 0.3076 mL | 1.5378 mL | 3.0755 mL | 7.6888 mL | |
| 15 mM | 0.2050 mL | 1.0252 mL | 2.0503 mL | 5.1258 mL | |
| 20 mM | 0.1538 mL | 0.7689 mL | 1.5378 mL | 3.8444 mL | |
| 25 mM | 0.1230 mL | 0.6151 mL | 1.2302 mL | 3.0755 mL | |
| 30 mM | 0.1025 mL | 0.5126 mL | 1.0252 mL | 2.5629 mL | |
| 40 mM | 0.0769 mL | 0.3844 mL | 0.7689 mL | 1.9222 mL | |
| 50 mM | 0.0615 mL | 0.3076 mL | 0.6151 mL | 1.5378 mL | |
| 60 mM | 0.0513 mL | 0.2563 mL | 0.5126 mL | 1.2815 mL | |
| 80 mM | 0.0384 mL | 0.1922 mL | 0.3844 mL | 0.9611 mL | |
| 100 mM | 0.0308 mL | 0.1538 mL | 0.3076 mL | 0.7689 mL |
JAK-2/3-IN-3 Related Classifications
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