2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. TK4b

TK4b is a dual JAK2/3 inhibitor with human JAK2 and JAK3 IC50s of 19.40 nM and 18.42 nM, respectively. TK4b can be used for the research of leukemia and myelofibrosis.

For research use only. We do not sell to patients.

TK4b

TK4b Chemical Structure

CAS No. : 2232890-81-0

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TK4b Related Antibodies

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Description

TK4b is a dual JAK2/3 inhibitor with human JAK2 and JAK3 IC50s of 19.40 nM and 18.42 nM, respectively. TK4b can be used for the research of leukemia and myelofibrosis[1].

IC50 & Target[1]

JAK2

19.40 nM (IC50)

JAK3

18.42 nM (IC50)

In Vitro

TK4b (1 μM; 1 h) potently inhibits purified JAK2 with an IC50 of 19.40 nM and purified JAK3 with an IC50 of 18.42 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TK4b Related Antibodies
Molecular Weight

334.41

Formula

C21H22N2O2
CAS No.
SMILES

O=C1N(C2=CC=C(C)C(C)=C2)N(CC)C(C)=C1C(C3=CC=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TK4b Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TK4b2232890-81-0JAKJanus kinaselymphoid-derived diseasesmyelofibrosisJanus kinase 2leukemiaJAK2JAK3Janus kinase 3tofacitinibInhibitorinhibitorinhibit

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