2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. JAK2-IN-5

JAK2-IN-5 (Compound 13) is a selective JAK kinase inhibitor, with an IC50 of 0.078 μM against JAK-2 and an IC50 of 0.206 μM against JAK-2V617F. JAK2-IN-5 can be used for the research of myeloproliferative disorders.

For research use only. We do not sell to patients.

JAK2-IN-5

JAK2-IN-5 Chemical Structure

CAS No. : 1110502-30-1

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JAK2-IN-5 Related Antibodies

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Description

JAK2-IN-5 (Compound 13) is a selective JAK kinase inhibitor, with an IC50 of 0.078 μM against JAK-2 and an IC50 of 0.206 μM against JAK-2V617F. JAK2-IN-5 can be used for the research of myeloproliferative disorders[1].

IC50 & Target[1]

JAK2

0.078 μM (IC50)

JAK2V617F

0.206 μM (IC50)

In Vitro

JAK2-IN-5 potently inhibits JAK-2 WT kinase with an IC50 of 78 nM and a ligand efficiency of 0.41 kcal mol-1[1].
JAK2-IN-5 inhibits JAK-2V617F mutant kinase with an IC50 of 206 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JAK2-IN-5 Related Antibodies
Molecular Weight

344.43

Formula

C17H20N4O2S
CAS No.
SMILES

O=S(=O)(NC(C)(C)C)C=1C=CC(=CC1)C2=CC=C3NN=C(N)C3=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JAK2-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK2-IN-51110502-30-1JAKJanus kinasewild-type JAK-2JAK-2myeloproliferative disordersJAK-3JAK-2 V617FJAK-2 WT kinaseJAK kinaseInhibitorinhibitorinhibit

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