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Cat. No.: HY-136734

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JAK2-IN-5

JAK2-IN-5 (Compound 13) is a selective JAK kinase inhibitor, with an IC₅₀ of 0.078 μM against JAK-2 and an IC₅₀ of 0.206 μM against JAK-2^V617F. JAK2-IN-5 can be used for the research of myeloproliferative disorders.

For research use only. We do not sell to patients.

CAS No.: 1110502-30-1
Formula: C₁₇H₂₀N₄O₂S
Molecular Weight:344.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

JAK2-IN-5 Chemical Structure

CAS No.: 1110502-30-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

JAK2

0.078 μM (IC₅₀)

JAK2^V617F

0.206 μM (IC₅₀)

All JAK Isoforms :

In Vitro

JAK2-IN-5 potently inhibits JAK-2 WT kinase with an IC₅₀ of 78 nM and a ligand efficiency of 0.41 kcal mol^-1^[1].
JAK2-IN-5 inhibits JAK-2^V617F mutant kinase with an IC₅₀ of 206 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1110502-30-1
Molecular Weight 344.43
Formula C₁₇H₂₀N₄O₂S
SMILES

O=S(=O)(NC(C)(C)C)C=1C=CC(=CC1)C2=CC=C3NN=C(N)C3=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Antonysamy S, et al. Fragment-based discovery of JAK-2 inhibitors. Bioorg Med Chem Lett. 2009;19(1):279-282. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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