1. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling Autophagy
  2. JAK Autophagy
  3. NSC 33994

NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM.

For research use only. We do not sell to patients.

NSC 33994 Chemical Structure

NSC 33994 Chemical Structure

CAS No. : 82058-16-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products

View All JAK Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM[1].

IC50 & Target[1]

JAK2

60 nM (IC50, JAK2 Val617Phe kinase activity )

In Vitro

NSC 33994 (G6) reduces the levels of phospho-JAK2 in both a dose- and time-dependent manner[1].
NSC 33994 (G6, 0-25 μM, 0-48 h) inhibits phospho-JAK2 (pY1007/pY1008) in a dose-dependent and time-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

438.65

Formula

C28H42N2O2

CAS No.
SMILES

CC/C(C1=CC=C(O)C(CN(CC)CC)=C1)=C(C2=CC=C(O)C(CN(CC)CC)=C2)/CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
NSC 33994
Cat. No.:
HY-18293
Quantity:
MCE Japan Authorized Agent: