1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. NSC 33994

NSC 33994 

Cat. No.: HY-18293
Handling Instructions

NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM.

For research use only. We do not sell to patients.

NSC 33994 Chemical Structure

NSC 33994 Chemical Structure

CAS No. : 82058-16-0

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Description

NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM[1].

IC50 & Target[1]

JAK2

60 nM (IC50, JAK2 Val617Phe kinase activity )

In Vitro

NSC 33994 (G6) reduces the levels of phospho-JAK2 in both a dose- and time-dependent manner[1].
NSC 33994 (G6, 0-25 μM, 0-48 h) inhibits phospho-JAK2 (pY1007/pY1008) in a dose-dependent and time-dependent manner[1].

Molecular Weight

438.65

Formula

C₂₈H₄₂N₂O₂

CAS No.

82058-16-0

SMILES

CC/C(C1=CC=C(O)C(CN(CC)CC)=C1)=C(C2=CC=C(O)C(CN(CC)CC)=C2)/CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

NSC 33994NSC33994NSC-33994JAKJanus kinaseInhibitorinhibitorinhibit

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NSC 33994
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