2. Gene
  3. Ctsl - cathepsin L Gene

Ctsl - cathepsin L Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as CatL; CATHL; Ctsl1

Gene ID: 25697 | Gene type: protein coding

About Ctsl

Primary_assembly 17: 764,309-770,548 forward strand.mRatBN7.2:CM026990.1

This gene has 2 transcripts (splice variants), 711 orthologues, 27 paralogues and is associated with 26 phenotypes. Biased expression in Kidney (RPKM 13282.8), Liver (RPKM 4121.4) and 6 other tissues.

Summary

Enables kininogen binding activity; peptidase activity; and peptide binding activity. Involved in several processes, including autophagic cell death; reproductive structure development; and response to odorant. Located in several cellular components, including external side of plasma membrane; microvillus; and perikaryon. Colocalizes with apical part of cell and secretory granule. Used to study hepatocellular carcinoma. Biomarker of several diseases, including brain ischemia; hyperthyroidism; muscular atrophy; otitis media; and pancreatitis. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSV (Cathepsin V). [provided by Alliance of Genome Resources, Apr 2022]

Ctsl Products(1)

mRNA Protein Name
NM_013156.2 NP_037288.1 procathepsin L preproprotein

Ctsl Protein Structure

Inhibitor_I29

Inhibitor_I29: smart00848 (28 - 86)

Peptidase_C1

Peptidase_C1: pfam00112 (113 - 331)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

procathepsin L

CP-2

MEP

cathepsin L1

cyclic protein 2

major excreted protein

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-137978A Ezurpimtrostat hydrochloride Inhibitor 98.29% Phase 2
HY-137978 Ezurpimtrostat Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-128140 Z-FY-CHO Inhibitor 96.18% Unkown
HY-119293 K777 99.77% Unkown
HY-157477 SARS-CoV-2 3CLpro-IN-22 Inhibitor / Unkown
HY-158022 CTSL/CAPN1-IN-1 Inhibitor / Unkown
HY-161342 CTSL/CAPN1-IN-2 Inhibitor / Unkown
HY-RS03340 CTSL Human Pre-designed siRNA Set A / Unkown
HY-RS03341 Ctsl Mouse Pre-designed siRNA Set A / Unkown
HY-RS03342 Ctsl Rat Pre-designed siRNA Set A / Unkown
HY-163029 CTSL/B-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsl NCBI NCBI:1514
Mus musculus Ctsl NCBI NCBI:13039