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GCA - grancalcin Gene

Also Known as GCL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25801

About GCA

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:162,318,763-162,375,396 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues and 20 paralogues. Broad expression in bone marrow (RPKM 47.3), appendix (RPKM 18.4) and 18 other tissues.

Summary

This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Aug 2016]

GCA Products (7)

mRNA	Protein	Name
NM_001330265.1	NP_001317194.1	grancalcin isoform a
NM_001330266.1	NP_001317195.1	grancalcin isoform a
NM_001330267.1	NP_001317196.1	grancalcin isoform a
NM_001330268.1	NP_001317197.1	grancalcin isoform c
NM_001330270.2	NP_001317199.1	grancalcin isoform d
NM_001330271.2	NP_001317200.1	grancalcin isoform d
NM_012198.5	NP_036330.1	grancalcin isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	11717497	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	12804766	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	11717497	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GCA Protein Structure

EF-hand_8

EF-hand_6

0
100
200
217 a.a.

Protein Preferred Names	Protein Names
grancalcin	grancalcin, EF-hand calcium-binding protein

GCA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GCA	P28676	MAGEA8	Homo sapiens	P43361	Validated Y2H	32296183
Intra	GCA	P28676	MAGEA8	Homo sapiens	P43361	Y2H Array	31515488
Intra	GCA	P28676	MAGEA8	Homo sapiens	P43361	Y2H Prey Pooling	32296183
Intra	GCA	P28676	MAGEA8	Homo sapiens	P43361	Y2H Array	32296183
Intra	GCA	P28676	MAGEA8	Homo sapiens	P43361	Y2H Array	25416956
Intra	GCA	P28676	MAGEA8	Homo sapiens	P43361	Y2H Array	29892012
Intra	GCA	P28676	MAGEA8	Homo sapiens	P43361	Validated Y2H	25416956
Intra	GCA	P28676	GSTO2	Homo sapiens	Q9H4Y5	Y2H Array	32296183
Intra	GCA	P28676	GSTO2	Homo sapiens	Q9H4Y5	Validated Y2H	32296183
Intra	GCA	P28676	GSTO2	Homo sapiens	Q9H4Y5	Y2H Prey Pooling	32296183
Intra	GCA	P28676	ABHD11	Homo sapiens	Q8NFV4-4	Validated Y2H	32296183
Intra	GCA	P28676	ABHD11	Homo sapiens	Q8NFV4-4	Y2H Array	32296183
Intra	GCA	P28676	ABHD11	Homo sapiens	Q8NFV4-4	Y2H Prey Pooling	32296183
Intra	GCA	P28676	C10orf55	Homo sapiens	Q5SWW7	Y2H Prey Pooling	32296183
Intra	GCA	P28676	C10orf55	Homo sapiens	Q5SWW7	Validated Y2H	32296183
Intra	GCA	P28676	C10orf55	Homo sapiens	Q5SWW7	Y2H Array	32296183
Intra	GCA	P28676	CSTPP1	Homo sapiens	Q9H6J7-2	Validated Y2H	32296183
Intra	GCA	P28676	CSTPP1	Homo sapiens	Q9H6J7-2	Y2H Array	32296183
Intra	GCA	P28676	CSTPP1	Homo sapiens	Q9H6J7-2	Y2H Prey Pooling	32296183
Intra	GCA	P28676	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	GCA	P28676	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	GCA	P28676	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	GCA	P28676	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	GCA	P28676	TRAF1	Homo sapiens	Q13077	Validated Y2H	32296183
Intra	GCA	P28676	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	GCA	P28676	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	GCA	P28676	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	GCA	P28676	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	GCA	P28676	PSMB4	Homo sapiens	P28070	Y2H Array	32296183
Intra	GCA	P28676	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	32296183
Intra	GCA	P28676	CALCOCO2	Homo sapiens	Q13137	Y2H Array	32296183
Intra	GCA	P28676	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	32296183
Intra	GCA	P28676	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	GCA	P28676	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	GCA	P28676	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	GCA	P28676	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	GCA	P28676	BPIFA1	Homo sapiens	Q9NP55	Validated Y2H	32296183
Intra	GCA	P28676	BPIFA1	Homo sapiens	Q9NP55	Y2H Array	32296183
Intra	GCA	P28676	BPIFA1	Homo sapiens	Q9NP55	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GCA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70334	Grancalcin/GCA Protein, Human (His)	P28676 (M1-I217)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72635	Grancalcin/GCA Protein, Human (GST)	P28676 (M1-I217)	≥ 95%, as determined by reducing SDS-PAGE.

GCA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811277	Grancalcin Antibody	WB, ICC/IF	Human, Mouse

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108753	Eteplirsen	Inducer	98.50%	Phase 3
HY-142118	Trabedersen	Inhibitor	91.24%	Phase 3
HY-132596	Tivanisiran	Inhibitor	97.48%	Phase 3
HY-145721	Mongersen	Inhibitor	98.57%	Phase 3
HY-145728	Alicaforsen	Inhibitor	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100540	Golgicide A	Inhibitor	99.94%	Unkown
HY-143230	Custirsen	Inducer	96.12%	Unkown
HY-149453	MCUF-651	Modulator	99.85%	Unkown
HY-148100	Emapticap pegol	Inhibitor	91.38%	Unkown
HY-100540B	Golgicide A-2	Inhibitor	99.53%	Unkown
HY-100540C	Golgicide A-1	Control	99.94%	Unkown
HY-100540A	(Rac)-Golgicide A	Inhibitor	/	Unkown
HY-116528	GCA-186	Inhibitor	/	Unkown
HY-150213	ODN BW001	Inhibitor	/	Unkown
HY-RS05317	GCA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16824	Gca Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18627	Npr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19509	Guca1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23264	Gca Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25113	Npr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GCA	MGD	MGI:1918521
Macaca mulatta	GCA	VGNC	VGNC:72726
Canis familiaris	GCA	VGNC	VGNC:41137
Rattus norvegicus	GCA	RGD	RGD:1306589
Felis catus	GCA	VGNC	VGNC:80217
Bos taurus	GCA	VGNC	VGNC:29278
Others	GCA	NCBI