METTL7A - methyltransferase like 7A Gene

Also Known as AAMB; AAM-B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25840

About METTL7A

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,925,015-50,932,508 (from NCBI)

This gene has 5 transcripts (splice variants), 311 orthologues and 4 paralogues. Broad expression in liver (RPKM 132.2), thyroid (RPKM 109.3) and 24 other tissues.

Summary

Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Located in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]

METTL7A Products (1)

mRNA Protein Name
NM_014033.4 NP_054752.3 putative methyltransferase-like protein 7A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA methyltransferase activity IDA
IDA: Inferred from direct assay
34980213 GOA
enables mRNA m(6)A methyltransferase activity IMP
IMP: Inferred from mutant phenotype
34226523 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
enables thiol S-methyltransferase activity IDA
IDA: Inferred from direct assay
37137720 GOA
Biological Process GO Annotation Evidence References Source
involved in lncRNA processing IMP
IMP: Inferred from mutant phenotype
34980213 GOA
involved in odontogenesis IMP
IMP: Inferred from mutant phenotype
34790668 GOA
involved in osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
34226523 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
19773358 GOA
located in lipid droplet IDA
IDA: Inferred from direct assay
18477614 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL7A Protein Structure

Methyltransf_11

Methyltransf_11: Methyltransferase domain (75 - 172)

  • 0
  • 100
  • 200
  • 244 a.a.
Protein Preferred Names Protein Names

putative methyltransferase-like protein 7A

  • methyltransferase-like protein 7A

METTL7A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMT1A Q9H8H3 NDUFS3 Homo sapiens O75489
Y2H Array
32814053
Intra
TMT1A Q9H8H3 NDUFS3 Homo sapiens O75489
Y2H Pooling
32814053
Intra
TMT1A Q9H8H3 NDUFS3 Homo sapiens O75489
Validated Y2H
32814053
Intra
TMT1A Q9H8H3 PRKCA Homo sapiens P17252
Validated Y2H
32814053
Intra
TMT1A Q9H8H3 PRKCA Homo sapiens P17252
Y2H Pooling
32814053
Intra
TMT1A Q9H8H3 PRKCA Homo sapiens P17252
Y2H Array
32814053
Intra
TMT1A Q9H8H3 PPIA Homo sapiens P62937-2
Y2H Pooling
32814053
Intra
TMT1A Q9H8H3 PPIA Homo sapiens P62937-2
Validated Y2H
32814053
Intra
TMT1A Q9H8H3 PPIA Homo sapiens P62937-2
Y2H Array
32814053
Intra
TMT1A Q9H8H3 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
TMT1A Q9H8H3 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
TMT1A Q9H8H3 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
TMT1A Q9H8H3 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
TMT1A Q9H8H3 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
TMT1A Q9H8H3 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
TMT1A Q9H8H3 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
TMT1A Q9H8H3 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
TMT1A Q9H8H3 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
TMT1A Q9H8H3 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
Intra
TMT1A Q9H8H3 KAT5 Homo sapiens Q92993
Y2H Array
32814053
Intra
TMT1A Q9H8H3 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
Intra
TMT1A Q9H8H3 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
TMT1A Q9H8H3 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Intra
TMT1A Q9H8H3 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Malignant Otitis Externa

  • Necrotising Otitis Externa

  • Pseudomonas Aeruginosa Osteomyelitis Of The Temporal Bone
Pulmonary Aspergilloma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08368 METTL7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta METTL7A VGNC VGNC:74567
Felis catus METTL7A VGNC VGNC:97506
Rattus norvegicus METTL7A RGD RGD:1308407
Canis familiaris METTL7A VGNC VGNC:43180