Mapk1 - mitogen-activated protein kinase 1 Gene

Also Known as ERK; Erk2; MAPK2; PRKM2; Prkm1; p41mapk; p42mapk; 9030612K14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26413

About Mapk1

Chromosome 16: 16,801,246-16,865,317 forward strand.GRCm39:CM001009.3

This gene has 9 transcripts (splice variants), 214 orthologues, 19 paralogues and is associated with 35 phenotypes. Ubiquitous expression in frontal lobe adult (RPKM 69.7), cortex adult (RPKM 53.9) and 28 other tissues.

Summary

Enables several functions, including identical protein binding activity; phosphotyrosine residue binding activity; and protein kinase activity. Involved in peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and response to nicotine. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and cellular response to cytokine stimulus. Located in several cellular components, including cytosol; mitochondrion; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome; autism spectrum disorder; and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in Noonan syndrome 13; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mapk1 Products (3)

mRNA Protein Name
NM_011949.3 NP_036079.1 mitogen-activated protein kinase 1
NM_001357115.1 NP_001344044.1 mitogen-activated protein kinase 1
NM_001038663.1 NP_001033752.1 mitogen-activated protein kinase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MAP kinase activity IDA
IDA: Inferred from direct assay
1659995 MGI
enables MAP kinase activity IMP
IMP: Inferred from mutant phenotype
11841548 MGI
enables RNA polymerase II CTD heptapeptide repeat kinase activity IDA
IDA: Inferred from direct assay
12721286 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
26267534 MGI
enables kinase activity IDA
IDA: Inferred from direct assay
12808090 MGI
enables phosphatase binding IPI
IPI: Inferred from physical interaction
8221888 MGI
enables phosphotyrosine residue binding IMP
IMP: Inferred from mutant phenotype
14636584 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10419510 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
14744933 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11854404 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell receptor signaling pathway IDA
IDA: Inferred from direct assay
9254656 MGI
acts upstream of or within Bergmann glial cell differentiation IGI
IGI: Inferred from genetic interaction
24431450 MGI
acts upstream of or within DNA damage response IDA
IDA: Inferred from direct assay
15383658 MGI
involved in ERBB2-ERBB3 signaling pathway IDA
IDA: Inferred from direct assay
24493648 MGI
acts upstream of or within ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
19047410 MGI
acts upstream of or within MAPK cascade IDA
IDA: Inferred from direct assay
8626447 MGI
involved in MAPK cascade IGI
IGI: Inferred from genetic interaction
21220101 MGI
involved in Schwann cell development IMP
IMP: Inferred from mutant phenotype
10704452 MGI
acts upstream of or within T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
9064344 MGI
acts upstream of or within animal organ morphogenesis IDA
IDA: Inferred from direct assay
11684667 MGI
acts upstream of or within cardiac neural crest cell development involved in heart development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within cellular response to tumor necrosis factor IGI
IGI: Inferred from genetic interaction
24349514 MGI
acts upstream of or within cytosine metabolic process IDA
IDA: Inferred from direct assay
15284227 MGI
acts upstream of or within face development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within face development IMP
IMP: Inferred from mutant phenotype
18952847 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
18952847 MGI
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
20056832 MGI
involved in insulin-like growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
14997210 MGI
acts upstream of or within labyrinthine layer blood vessel development IMP
IMP: Inferred from mutant phenotype
14622137 MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway IDA
IDA: Inferred from direct assay
12872135 MGI
acts upstream of or within long-term synaptic potentiation IGI
IGI: Inferred from genetic interaction
20661302 MGI
acts upstream of or within lung morphogenesis IGI
IGI: Inferred from genetic interaction
25100655 MGI
acts upstream of or within mammary gland epithelial cell proliferation IDA
IDA: Inferred from direct assay
18604197 MGI
involved in myelination IMP
IMP: Inferred from mutant phenotype
10704452 MGI
acts upstream of or within negative regulation of cell differentiation IGI
IGI: Inferred from genetic interaction
14970190 MGI
acts upstream of or within neural crest cell development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within outer ear morphogenesis IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
18084034 MGI
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
11854404 MGI
acts upstream of or within peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
18084034 MGI
involved in peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
11854404 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
11841548 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
15896720 MGI
acts upstream of or within regulation of cellular pH IMP
IMP: Inferred from mutant phenotype
26375174 MGI
acts upstream of or within regulation of ossification IGI
IGI: Inferred from genetic interaction
20053668 MGI
acts upstream of or within response to exogenous dsRNA IDA
IDA: Inferred from direct assay
12872135 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: Inferred from direct assay
12872135 MGI
involved in response to nicotine IGI
IGI: Inferred from genetic interaction
11404397 MGI
acts upstream of or within thymus development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within thyroid gland development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within trachea formation IGI
IGI: Inferred from genetic interaction
25100655 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11726647 MGI
is active in cytosol IDA
IDA: Inferred from direct assay
22451653 MGI
located in cytosol IDA
IDA: Inferred from direct assay
9447983 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
11884367 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11726647 MGI
located in pseudopodium IDA
IDA: Inferred from direct assay
12821670 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk1 Protein Structure

STKc_ERK1_2_like

STKc_ERK1_2_like: cd07849 (16 - 350)

  • 0
  • 100
  • 200
  • 300
  • 358 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 1

  • ERK-2

  • ERT1

  • MAP kinase 1

  • MAP kinase 2

  • MAPK 1

  • MAPK 2

  • extracellular signal-regulated kinase 2

  • mitogen-activated protein kinase 2

  • p42-MAPK

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13285 Ki16425 99.14% Unkown
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-N2484 Methylnissolin Inhibitor 99.92% Unkown
HY-P2456 MBP MAPK Substrate 99.58% Unkown
HY-N0363 (+)-Columbianetin 99.04% Unkown
HY-113788 PF-719 99.52% Unkown
HY-N0363A (+)-Columbianetin acetate 99.83% Unkown
HY-149921 Antiangiogenic agent 3 Inhibitor / Unkown
HY-152087 DCZ19931 Inhibitor / Unkown
HY-172787 FGFR4-IN-23 Inhibitor / Unkown
HY-184145 AKT1-IN-13 / Unkown
HY-E70844 MAP2K2 Recombinant Human Active Protein Kinase / Unkown
HY-N12726 Halociline Inhibitor / Unkown
HY-N17458 N-Acetyldehydroanonaine Ligand / Unkown
HY-N3487 Isodorsmanin A / Unkown
HY-P0141 Akt/SKG Substrate Peptide / Unkown
HY-P0141A Akt/SKG Substrate Peptide TFA / Unkown
HY-RS08092 MAPK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08093 Mapk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08094 Mapk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08115 Mapk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N0363AR (+)-Columbianetin acetate (Standard) / Unkown
HY-N0363R (+)-Columbianetin (Standard) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk1 NCBI NCBI:5594