Mapk3 - mitogen-activated protein kinase 3 Gene

Also Known as p44; Erk1; Ert2; Mnk1; Erk-1; Esrk1; Prkm3; Mtap2k; p44erk1; p44mapk

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26417

About Mapk3

Chromosome 7: 126,358,773-126,364,991 forward strand.GRCm39:CM001000.3

This gene has 8 transcripts (splice variants), 198 orthologues, 19 paralogues and is associated with 12 phenotypes. Ubiquitous expression in colon adult (RPKM 245.8), large intestine adult (RPKM 217.1) and 28 other tissues.

Summary

Enables MAP kinase activity; MAP kinase kinase activity; and phosphotyrosine residue binding activity. Involved in several processes, including negative regulation of Apolipoprotein binding activity; regulation of DNA-binding transcription factor activity; and sensory perception of pain. Acts upstream of or within several processes, including Bergmann glial cell differentiation; ERK1 and ERK2 cascade; and animal organ development. Located in cytosol; nucleus; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; endometrial adenocarcinoma; pancreatic ductal carcinoma; and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Mapk3 Products (1)

mRNA Protein Name
NM_011952.2 NP_036082.1 mitogen-activated protein kinase 3

Mapk3 Protein Structure

STKc_ERK1_2_like

STKc_ERK1_2_like: cd07849 (36 - 370)

  • 0
  • 100
  • 200
  • 300
  • 380 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 3

  • MAP kinase 3

  • extracellular signal-regulated kinase 1

  • insulin-stimulated MAP2 kinase

  • microtubule-associated protein 2 kinase

  • p44 MAP kinase

  • pp42/MAP kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70844 MAP2K2 Recombinant Human Active Protein Kinase / Unkown
HY-RS08113 MAPK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08114 Mapk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08115 Mapk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk3 NCBI NCBI:5595