2. Gene
  3. Mapk3 - mitogen-activated protein kinase 3 Gene

Mapk3 - mitogen-activated protein kinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as p44; Erk1; Ert2; Mnk1; Erk-1; Esrk1; Prkm3; Mtap2k; p44erk1; p44mapk

Gene ID: 26417 | Gene type: protein coding

About Mapk3

Chromosome 7: 126,358,773-126,364,991 forward strand.GRCm39:CM001000.3

This gene has 8 transcripts (splice variants), 198 orthologues, 19 paralogues and is associated with 12 phenotypes. Ubiquitous expression in colon adult (RPKM 245.8), large intestine adult (RPKM 217.1) and 28 other tissues.

Summary

Enables MAP kinase activity; MAP kinase kinase activity; and phosphotyrosine residue binding activity. Involved in several processes, including negative regulation of apolipoprotein binding activity; regulation of DNA-binding transcription factor activity; and sensory perception of pain. Acts upstream of or within several processes, including Bergmann glial cell differentiation; ERK1 and ERK2 cascade; and animal organ development. Located in cytosol; nucleus; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; endometrial adenocarcinoma; pancreatic ductal carcinoma; and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Mapk3 Products(1)

mRNA Protein Name
NM_011952.2 NP_036082.1 mitogen-activated protein kinase 3

Mapk3 Protein Structure

STKc_ERK1_2_like

STKc_ERK1_2_like: cd07849 (36 - 370)

  • 0
  • 100
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  • 380 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 3

MAP kinase 3

extracellular signal-regulated kinase 1

insulin-stimulated MAP2 kinase

microtubule-associated protein 2 kinase

p44 MAP kinase

pp42/MAP kinase

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08113 MAPK3 Human Pre-designed siRNA Set A / Unkown
HY-RS08114 Mapk3 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08115 Mapk3 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk3 NCBI NCBI:5595