Irf5 - interferon regulatory factor 5 Gene

Also Known as mirf5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27056

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and protein kinase binding activity. Involved in cytokine-mediated signaling pathway; defense response to Other organism; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in eye; ovary; telencephalon; and urinary system. Human ortholog(s) of this gene implicated in herpes simplex; inflammatory bowel disease 14; multiple sclerosis; rheumatoid arthritis; and systemic lupus erythematosus. Orthologous to human IRF5 (interferon regulatory factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Irf5 Products (3)

mRNA Protein Name
NM_001252382.1 NP_001239311.1 interferon regulatory factor 5 isoform 1
NM_001311083.1 NP_001298012.1 interferon regulatory factor 5 isoform 3
NM_012057.4 NP_036187.1 interferon regulatory factor 5 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15665823 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16236719 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
25326420 MGI
Biological Process GO Annotation Evidence References Source
involved in cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
15665823 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
20451243 MGI
involved in innate immune response IDA
IDA: Inferred from direct assay
15665823 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15665823 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15665823 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15665823 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon regulatory factor 5

  • interferon regulatory factor 5 bone marrow

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-146244 Agatolimod 98.84% Unkown
HY-149652 IRF5-IN-1 Inhibitor 99.91% Unkown
HY-150095 YE6144 Inhibitor 96.47% Unkown
HY-175759 EN1033 99.96% Unkown
HY-P11072 IRF5-CPP5 Inhibitor 99.23% Unkown
HY-113509B 15(R)-Lipoxin A4 98.3% Unkown
HY-P11003 PTD-N5-1 Inhibitor / Unkown
HY-RS06909 IRF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-150095A YE6144 free base Inhibitor / Unkown
HY-RS16837 Irf5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23279 Irf5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991956 ABB071 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irf5 NCBI NCBI:3663