HSPB7 - heat shock protein family B (small) member 7 Gene

Also Known as cvHSP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27129

About HSPB7

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:16,014,029-16,019,594 (from NCBI)

This gene has 7 transcripts (splice variants), 256 orthologues and 8 paralogues. Biased expression in heart (RPKM 547.7) and fat (RPKM 156.2).

Summary

This gene encodes a small heat shock family B member that can heterodimerize with similar heat shock proteins. Defects in this gene are associated with advanced heart failure. In addition, the encoded protein may be a tumor suppressor in the p53 pathway, with defects in this gene being associated with renal cell carcinoma. [provided by RefSeq, Mar 2017]

HSPB7 Products (8)

mRNA Protein Name
NM_001349682.2 NP_001336611.1 heat shock protein beta-7 isoform 1
NM_001349683.2 NP_001336612.1 heat shock protein beta-7 isoform 3
NM_001349685.2 NP_001336614.1 heat shock protein beta-7 isoform 4
NM_001349686.2 NP_001336615.1 heat shock protein beta-7 isoform 5
NM_001349687.2 NP_001336616.1 heat shock protein beta-7 isoform 6
NM_001349688.2 NP_001336617.1 heat shock protein beta-7 isoform 7
NM_001349689.2 NP_001336618.1 heat shock protein beta-7 isoform 8
NM_014424.5 NP_055239.1 heat shock protein beta-7 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14594798 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19464326 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19464326 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPB7 Protein Structure

HSP20

HSP20: Hsp20/alpha crystallin family (76 - 159)

  • 0
  • 100
  • 170 a.a.
Protein Preferred Names Protein Names

heat shock protein beta-7

  • cardiovascular heat shock protein

HSPB7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HSPB7 Q9UBY9 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
HSPB7 Q9UBY9 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
HSPB7 Q9UBY9 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra
HSPB7 Q9UBY9 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra
HSPB7 Q9UBY9 UBXN1 Homo sapiens Q04323-2
Y2H Array
32296183
Intra
HSPB7 Q9UBY9 UBXN1 Homo sapiens Q04323-2
Y2H Prey Pooling
32296183
Intra
HSPB7 Q9UBY9 PIP4K2B Homo sapiens P78356-2
Y2H Prey Pooling
32296183
Intra
HSPB7 Q9UBY9 PIP4K2B Homo sapiens P78356-2
Y2H Array
32296183
Intra
HSPB7 Q9UBY9 DYNLT1 Homo sapiens P63172
Y2H Array
32296183
Intra
HSPB7 Q9UBY9 DYNLT1 Homo sapiens P63172
Y2H Prey Pooling
32296183
Intra
HSPB7 Q9UBY9 C22orf15 Homo sapiens Q8WYQ4-2
Y2H Array
32296183
Intra
HSPB7 Q9UBY9 C22orf15 Homo sapiens Q8WYQ4-2
Y2H Prey Pooling
32296183
Intra
HSPB7 Q9UBY9 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
HSPB7 Q9UBY9 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
HSPB7 Q9UBY9 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
HSPB7 Q9UBY9 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
HSPB7 Q9UBY9 SF3B4 Homo sapiens Q15427
Validated Y2H
25416956
Intra
HSPB7 Q9UBY9 PDLIM7 Homo sapiens Q9NR12
Y2H Prey Pooling
32296183
Intra
HSPB7 Q9UBY9 PDLIM7 Homo sapiens Q9NR12
Y2H Array
32296183
Intra
HSPB7 Q9UBY9 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
25416956
Intra
HSPB7 Q9UBY9 SYCE1 Homo sapiens Q8N0S2
Y2H Prey Pooling
25416956
Intra
HSPB7 Q9UBY9 HSPB8 Homo sapiens Q9UJY1
Anti Tag CoIP
14594798
Intra
HSPB7 Q9UBY9 HSPB8 Homo sapiens Q9UJY1
Validated Y2H
32296183
Intra
HSPB7 Q9UBY9 HSPB8 Homo sapiens Q9UJY1
Y2H Array
32296183
Intra
HSPB7 Q9UBY9 HSPB8 Homo sapiens Q9UJY1
Y2H
14594798
Intra
HSPB7 Q9UBY9 HSPB8 Homo sapiens Q9UJY1
FRET
14594798
Intra
HSPB7 Q9UBY9 HSPB8 Homo sapiens Q9UJY1
Validated Y2H
25416956
Intra
HSPB7 Q9UBY9 HSPB8 Homo sapiens Q9UJY1
Y2H Prey Pooling
32296183
Intra
HSPB7 Q9UBY9 TRIM23 Homo sapiens P36406
Y2H Array
25416956
Intra
HSPB7 Q9UBY9 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
Intra
HSPB7 Q9UBY9 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
HSPB7 Q9UBY9 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
HSPB7 Q9UBY9 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
Intra
HSPB7 Q9UBY9 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
25416956
Intra
HSPB7 Q9UBY9 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
25416956
Intra
HSPB7 Q9UBY9 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
Intra
HSPB7 Q9UBY9 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
25416956
Intra
HSPB7 Q9UBY9 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
25416956
Intra
HSPB7 Q9UBY9 CEP76 Homo sapiens Q8TAP6
Validated Y2H
25416956
Intra
HSPB7 Q9UBY9 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra
HSPB7 Q9UBY9 CEP76 Homo sapiens Q8TAP6
Y2H Array
25416956
Intra
HSPB7 Q9UBY9 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra
HSPB7 Q9UBY9 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra
HSPB7 Q9UBY9 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra
HSPB7 Q9UBY9 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra
HSPB7 Q9UBY9 FLNA Homo sapiens P21333-2
Anti Tag CoIP
28514442
Intra
HSPB7 Q9UBY9 FLNA Homo sapiens P21333-2
Y2H Array
32296183
Intra
HSPB7 Q9UBY9 FLNA Homo sapiens P21333-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HSPB7 Proteins

Cat. No. Product Name Accession Purity
HY-P70929 HSPB7 Protein, Human (His) Q9UBY9 (M1-I170) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Paraneoplastic Polyneuropathy
Distal Hereditary Motor Neuronopathy Type 2

  • Distal Hereditary Motor Neuropathy, Type Ii

  • Distal Hereditary Motor Neuropathy Type 2

  • Distal Hereditary Motor Neuropathy Type Ii

  • Hmn Ii

  • Hmn2

  • Distal Hereditary Motor Neuronopathy, Type Ii

  • Distal Spinal Muscular Atrophy Type 2

  • Dhmn2

  • Dsma2

  • Neuropathy, Motor, Distal, Hereditary, Type Ii

  • Spinal Muscular Atrophy, Jerash Type
Myopathy, Myofibrillar, 5

  • Myofibrillar Myopathy 5

  • MFM5

  • Myopathy, Myofibrillar, Filamin C-Related

  • Filaminopathy, Autosomal Dominant

  • Filaminopathy

  • Muscle Filaminopathy

  • Autosomal Dominant Filaminopathy

  • Mfm Filamin C-Related

  • Myopathy Myofibrillar Filamin C-Related

  • Myopathy, Myofibrillar, Type 5
Systolic Heart Failure

  • Heart Failure, Systolic
Myofibrillar Myopathy

  • Desmin Related Myopathy

  • Myotilinopathy

  • Myopathy, Myofibrillar

  • Alpha Beta Crystallinopathy

  • Desmin Storage Myopathy

  • Desminopathy

  • Filaminopathy

  • Protein Surplus Myopathy

  • Zaspopathy

  • Myofibrillar Myopathies

  • Myopathy, Myofibrillar, Desmin-Related

  • Myopathy, Desmin Storage

  • Mfm - [Myofibrillar Myopathy]
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy

  • Hypertrophic Obstructive Cardiomyopathy

  • Cardiomyopathy, Hypertrophic

  • Cardiomyopathy Hypertrophic Obstructive

  • Cardiomyopathy, Hypertrophic, Familial

  • Idiopathic Myocardial Hypertrophy

  • Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Cardiomyopathy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Muscular Subaortic Stenosis

  • Hypertrophic Obstructive Subaortic Stenosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06442 HSPB7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HSPB7 MGD MGI:1352494
Rattus norvegicus HSPB7 RGD RGD:62021
Macaca mulatta HSPB7 VGNC VGNC:99972
Canis familiaris HSPB7 VGNC VGNC:52138
Felis catus HSPB7 VGNC VGNC:80236
Bos taurus HSPB7 VGNC VGNC:49068
Others HSPB7 NCBI