Pdk4 - pyruvate dehydrogenase kinase, isoenzyme 4 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27273

Summary

Predicted to enable ATP binding activity and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in several processes, including Insulin Receptor signaling pathway; regulation of bone resorption; and regulation of fatty acid metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and skin. Orthologous to human PDK4 (pyruvate dehydrogenase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Pdk4 Products (1)

mRNA Protein Name
NM_013743.2 NP_038771.1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
16606348 MGI
involved in insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19627255 MGI
involved in regulation of acetyl-CoA biosynthetic process from pyruvate IMP
IMP: Inferred from mutant phenotype
16606348 MGI
involved in regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
21803180 MGI
involved in regulation of cellular ketone metabolic process IMP
IMP: Inferred from mutant phenotype
16606348 MGI
involved in regulation of fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
19627255 MGI
involved in regulation of fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
16606348 MGI
involved in regulation of glucose metabolic process IMP
IMP: Inferred from mutant phenotype
16606348 MGI
involved in regulation of pH IMP
IMP: Inferred from mutant phenotype
22360721 MGI
involved in response to starvation IMP
IMP: Inferred from mutant phenotype
16606348 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

  • [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial

  • pyruvate dehydrogenase kinase 4

Recombinant Pdk4 Proteins

Cat. No. Product Name Accession Purity
HY-P74639 PDK4 Protein, Mouse (sf9, His-GST) O70571 (M1-V412) ≥ 80%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135954A PDK4-IN-1 hydrochloride 99.72% Unkown
HY-12492 VER-246608 Inhibitor 99.10% Unkown
HY-121744 PS10 Inhibitor 98.51% Unkown
HY-135954 PDK4-IN-1 99.34% Unkown
HY-114702 M77976 Inhibitor 99.44% Unkown
HY-139185 PROTAC ERRα Degrader-3 Inhibitor 98.82% Unkown
HY-134908 DHNA Inhibitor 99.65% Unkown
HY-RS10278 PDK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-156109 PDK-IN-2 / Unkown
HY-157538 PDK4-IN-2 Inhibitor / Unkown
HY-183318 PPARα/δ agonist 4 Agonist / Unkown
HY-116257 GSK-7227 Agonist / Unkown
HY-RS16617 Pdk4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23052 Pdk4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdk4 NCBI NCBI:5166