Tnik - TRAF2 and NCK interacting kinase Gene

Also Known as RGD1561817

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 294917

About Tnik

Primary_assembly 2: 111,184,387-111,580,750 forward strand.mRatBN7.2:CM026975.1

This gene has 6 transcripts (splice variants), 268 orthologues, 36 paralogues and is associated with 8 phenotypes.

Summary

Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of dendrite morphogenesis. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynapse. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TNIK (TRAF2 and NCK interacting kinase). [provided by Alliance of Genome Resources, Apr 2022]

Tnik Products (1)

mRNA Protein Name
NM_001106422.1 NP_001099892.1 TRAF2 and NCK-interacting protein kinase

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
21048137 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20838393 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
20838393 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
20838393 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TRAF2 and NCK-interacting protein kinase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-160623 Rentosertib 99.96% Phase 2

Pre-clinical Phase

Bioactive Molecules (30)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100830 NCB-0846 Inhibitor 99.61% Unkown
HY-10371 Pim1/AAK1-IN-1 Inhibitor 98.40% Unkown
HY-111754 DMX-5804 Inhibitor 99.64% Unkown
HY-124745 KY-05009 99.88% Unkown
HY-N3127 Orobol Inhibitor 99.74% Unkown
HY-145293 TNIK-IN-3 Inhibitor 99.79% Unkown
HY-156816 ON 108600 Inhibitor 98.65% Unkown
HY-149591 M4K-2009 Inhibitor 99.35% Unkown
HY-124762 TNIK-IN-1 Inhibitor 99.25% Unkown
HY-156502 TINK-IN-1 Inhibitor 98.02% Unkown
HY-162314 TNIK-IN-8 Inhibitor 99.58% Unkown
HY-122805 PF-794 Inhibitor 99.19% Unkown
HY-156818 TNIK-IN-7 Inhibitor 99.65% Unkown
HY-100830A NCB-0970 Control 98.81% Unkown
HY-156817 TNIK-IN-6 Inhibitor 98.28% Unkown
HY-143437 TNIK-IN-5 Inhibitor 99.75% Unkown
HY-156523 TNIK&MAP4K4-IN-1 99.73% Unkown
HY-RS14832 Tnik Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14831 TNIK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-143436 TNIK-IN-4 Inhibitor / Unkown
HY-145292 TNIK-IN-2 Inhibitor 99.68% Unkown
HY-163478 TNIK-IN-9 Inhibitor / Unkown
HY-179111 HPK1-IN-64 Inhibitor / Unkown
HY-181930 TNIK-IN-10 / Unkown
HY-183059 TNIK-IN-11 Inhibitor / Unkown
HY-183950 ALK5-IN-87 Inhibitor / Unkown
HY-RS14833 Tnik Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W402208 MAP4K4-IN-7 Inhibitor / Unkown
HY-149591A M4K2009 hydrochloride Inhibitor / Unkown
HY-180857 TNIK modulator-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnik NCBI NCBI:23043