F8 - coagulation factor VIII Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 302470

Summary

Predicted to enable copper ion binding activity and oxidoreductase activity. Involved in blood coagulation, intrinsic pathway. Located in extracellular space. Used to study Factor VIII deficiency; hemarthrosis; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in Factor VIII deficiency. Orthologous to human F8 (coagulation Factor VIII). [provided by Alliance of Genome Resources, Apr 2022]

F8 Products (1)

mRNA Protein Name
NM_183331.2 NP_899160.2 coagulation factor VIII precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in blood coagulation, intrinsic pathway IMP
IMP: Inferred from mutant phenotype
2513867 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
2513867 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

coagulation factor VIII

  • coagulation factor VIII, procoagulant component

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9964 Necitumumab Inhibitor 99.90% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-107530 3F8 Inhibitor / Phase 2
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99155 Zalutumumab 98.34% Phase 3
HY-P99757 Nivatrotamab Inhibitor 99.00% Phase 2

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-171036 GAPDH-IN-1 Inhibitor 98.10% Unkown
HY-D2377 F8 98.25% Unkown
HY-157252 CL4F8-6 99.80% Unkown
HY-147844 F8-S43-S3 Inhibitor / Unkown
HY-147845 F8-S40 Inhibitor / Unkown
HY-157125 PI3Kα-IN-14 / Unkown
HY-RS04117 E2F8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04646 F8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04647 F8A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17355 F8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22149 E2f8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23809 F8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W391641 F8BT / Unkown
HY-W440913 DSPE-PEG5000-Cy5 / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990221 Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) Inhibitor ≥95.0% Unkown
HY-P990214 Anti-Mouse IL-3 Antibody (MP2-8F8) Inhibitor 95.00% Unkown
HY-P992000 F8-IL-4 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F8 NCBI NCBI:2157