PI3Kα-IN-14
PI3Kα-IN-14 (compound F8) is a selective PI3Kα inhibitor with an IC50 of 0.14 nM. PI3Kα-IN-14 induces a great decrease in mitochondrial membrane which caused cell cycle arrest at G1 phase and apoptosis in U87-MG cells. PI3Kα-IN-14 shows significant anti-proliferative activities against three tumor-derived cell lines (PC-3: IC50 of 0.28 μM; HCT-116: IC50 of 0.57 μM; and U87-MG: IC50 of 1.37 μM).
For research use only. We do not sell to patients.
- CAS No.: 3026856-46-9
- Formula: C28H29ClF2N10O4
- Molecular Weight:643.04
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PI3Kα 0.14 nM (IC50) |
PI3Kγ 2.45 nM (IC50) |
PI3Kδ 5.69 nM (IC50) |
PI3Kβ 25.89 nM (IC50) |
Chemical Information
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CAS No. 3026856-46-9
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Molecular Weight 643.04
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Formula C28H29ClF2N10O4
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SMILES
O=C(N1CCN(C2=NC(N3C(C(F)F)=NC4=C(OC)C=CC=C34)=NC(N5CCOCC5)=N2)CC1)NNC(C6=CC=C(Cl)C=C6)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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