F8 - coagulation factor VIII Gene

Also Known as AHF; F8B; F8C; HEMA; FVIII; THPH13; DXS1253E

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2157

About F8

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,835,792-155,022,723 (from NCBI)

This gene has 7 transcripts (splice variants), 149 orthologues, 35 paralogues and is associated with 6 phenotypes. Broad expression in fat (RPKM 7.9), lung (RPKM 6.4) and 23 other tissues.

Summary

This gene encodes coagulation Factor VIII, which participates in the intrinsic pathway of blood coagulation; Factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and Phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]

F8 Products (4)

mRNA	Protein	Name
NM_000132.4	NP_000123.1	coagulation factor VIII isoform a preproprotein
NM_019863.3	NP_063916.1	coagulation factor VIII isoform b
NM_000132.4	NP_000123.1	coagulation factor VIII isoform a preproprotein
NM_019863.3	NP_063916.1	coagulation factor VIII isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7756647	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F8 Protein Structure

Cu-oxidase_3

Cu-oxidase

Cu-oxidase_3

Cu-oxidase_2

F5_F8_type_C

0
400
800
1200
1600
2000
2351 a.a.

Protein Preferred Names	Protein Names
coagulation factor VIII	antihemophilic factor

F8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	F8	P00451	VWF	Homo sapiens	P04275	ELISA	18492805
Intra	F8	P00451	VWF	Homo sapiens	P04275	SPR	27749002

Cross: Cross-species interaction Intra: Intraspecies interaction

F8 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P85156	Factor VIII Antibody	WB, IHC-P, ICC/IF, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Hemophilia A	Factor Viii Deficiency Haemophilia A Mild Hemophilia A HEMA Hemophilia, Classic Classic Hemophilia Factor 8 Deficiency Severe Hemophilia A Classical Hemophilia Hem A Hemophilia A, Congenital Mild Congenital F8 Deficiency Mild Congenital Factor Viii Deficiency Severe Congenital F8 Deficiency Severe Congenital Factor Viii Deficiency Moderate Hemophilia A Moderate Congenital F8 Deficiency Moderate Congenital Factor Viii Deficiency Bleeding Disorder In Hemophilia A Carriers Congenital F8 Deficiency Congenital Fviii Deficiency Congenital Factor Viii Deficiency Mild Hereditary Factor Viii Deficiency Disease Severe Hereditary Factor Viii Deficiency Disease Ahg - [Antihaemophilic Globulin] Deficiency Ahg - [Antihaemophilic Globulin] Deficiency Disease Congenital Factor Viii Disorder Sex-Linked Factor Viii Deficiency Antihaemophilic Globulin Deficiency Classic Haemophilia Familial Haemophilia Haemophilia Hereditary Haemophilia Subhaemophilia Haemophilia Nos
Thrombophilia, X-Linked, Due To Factor Viii Defect	Thrombophilia 13, X-Linked, Due To Factor Viii Defect THPH13
Factor Viii Deficiency	Autosomal Hemophilia A Hemophilia A Autosomal Factor Viii Deficiency Classic Hemophilia A Congenital Factor Viii Disorder Subhemophilia Factor 8 Deficiency, Congenital Factor Viii
Hemophilia B	Christmas Disease Factor Ix Deficiency F9 Deficiency HEMB Plasma Thromboplastin Component Deficiency Congenital Factor Ix Deficiency Mild Hemophilia B Severe Hemophilia B Congenital Factor Ix Disorder Deficiency, Functional Factor Ix Hem B Mild Congenital F9 Deficiency Mild Congenital Factor Ix Deficiency Moderate Hemophilia B Moderate Congenital F9 Deficiency Moderate Congenital Factor Ix Deficiency Severe Congenital F9 Deficiency Severe Congenital Factor Ix Deficiency Bleeding Disorder In Hemophilia B Carriers Congenital F9 Deficiency Recessive X-Linked Hemophilia B
Hemophilia	Haemophilia Hemophilia, Familial Hemophilia, Hereditary Hemophilia A Hemophilia, Nos
Hemarthrosis	Haemarthrosis Of Shoulder Joint Haemarthrosis Of The Ankle And Foot Haemarthrosis Of The Pelvic Region And Thigh Hemarthrosis Involving Ankle And Foot Hemarthrosis Involving Forearm Hemarthrosis Involving Hand Hemarthrosis Involving Lower Leg Hemarthrosis Involving Pelvic Region And Thigh Hemarthrosis Involving Shoulder Region Hemarthrosis Involving Upper Arm Hemarthrosis Of Ankle And/Or Foot Hemarthrosis Of Forearm Hemarthrosis Of Hand Hemarthrosis Of Lower Leg Hemarthrosis Of Shoulder Hemarthrosis Of Shoulder Region Hemarthrosis Of The Ankle And Foot Hemarthrosis Of The Ankle And/Or Foot Hemarthrosis Of The Forearm Hemarthrosis Of The Hand Hemarthrosis Of The Lower Leg Hemarthrosis Of The Pelvic Region And Thigh Hemarthrosis Of The Shoulder Region Hemarthrosis Of The Upper Arm Hemarthrosis Of Upper Arm
Von Willebrand'S Disease	Von Willebrand Disease Von Willebrand Disorder Vascular Pseudohemophilia Hereditary Von Willebrand Disease Vwd Vascular Hemophilia Von Willebrand'S-Jurgens' Disease Von Willebrand-Jrgens Disease Von Willebrand Factor Deficiency Von Willebrand Factor, Deficiency Angiohemophilia Von Willebrand'S Factor Deficiency Von Willebrand Diseases Factor Viii Deficiency With Vascular Defect Vascular Haemophilia Willebrand Jurgen Thrombopathy Pseudohaemophilia Minot-Von Willebrand-Jurgen Disease Angiohaemophilia Angiohaemophilia A Angiohaemophilia B
Cardiac Tamponade	Pericardial Tamponade Rose'S Tamponade
Von Willebrand Disease, Type 1	Von Willebrand Disease Type 1 VWD1 Von Willebrand'S Disease 1 Von Willebrand Disease Type I Von Willebrand Disease, Type I Vwd, Type 1 Vwd Type 1 Von Willebrand Disease 1 Von Willebrand Factor Deficiency Type 1 Von Willebrand Disease, Type 1, Susceptibility To
Von Willebrand Disease, Type 3	Von Willebrand Disease Type 3 VWD3 Von Willebrand'S Disease 3 Von Willebrand Disease Type Iii Von Willebrand Disease, Type Iii Vwd, Type 3 Vwd Type 3 Von Willebrand Disease 3 Von Willebrand Disease Recessive Form Von Willebrand Factor Deficiency Type 3
Von Willebrand Disease, Type 2	Von Willebrand Disease Type 2m Von Willebrand Disease Type 2 Von Willebrand Disease Type 2a Von Willebrand Disease Type 2b Von Willebrand Disease Type 2n VWD2 Von Willebrand'S Disease 2 Von Willebrand Disease Type Ii Von Willebrand Disease, Type Ii Vwd, Type 2 Von Willebrand Disease, Types 2a, 2b, 2m, And 2n Vwd Type 2 Von Willebrand Disease 2 Von Willebrand Disease Normandy Variant Von Willebrand Disease Type 2 Malmo Von Willebrand Disease Type I New York Von Willebrand Factor Deficiency Type 2 Vwd2a Vwd2b Vwd2m Vwd2n Von Willebrand Disease, Type 2a, 2b, 2m, And 2n Von Willebrand Disease, Type 2a Von Willebrand Disease, Type 2b Von Willebrand Disease, Type 2n
Hemorrhagic Disease	Hemorrhagic Disorders Hemorrhagic Diathesis Hemorrhagic Diseases Bleeding Tendency Acquired Coagulation Factor Inhibitor Disorder Acquired Inhibitor Of Coagulation Antithrombinaemia Antithromboplastinogenaemia Circulating Anticoagulant Disorder Haemorrhagic Disorder Due To Antithrombinaemia Haemorrhagic Disorder Due To Excess Administered Heparin Antithromboplastinaemia Haemorrhagic Disorder Due To Hyperheparinemia
Thrombophilia	Hypercoagulability State
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Arthropathy	Ankylosis Of Ankle And Foot Joint Ankylosis Of Forearm Joint Ankylosis Of Hand Joint Ankylosis Of Joint Of Ankle And/Or Foot Ankylosis Of Joint Of Forearm Ankylosis Of Joint Of Hand Ankylosis Of Joint Of Lower Leg Ankylosis Of Joint Of Multiple Sites Ankylosis Of Joint Of Pelvic Region And Thigh Ankylosis Of Joint Of Shoulder Region Ankylosis Of Joint Of Upper Arm Ankylosis Of Lower Leg Joint Ankylosis Of Multiple Joints Ankylosis Of Upper Arm Joint Infectious Arthropathy Joint Ankylosis Of The Ankle And Foot Joint Ankylosis Of The Ankle And/Or Foot Joint Ankylosis Of The Forearm Joint Ankylosis Of The Hand Joint Ankylosis Of The Lower Leg Joint Ankylosis Of The Pelvic Region And Thigh Joint Ankylosis Of The Shoulder Region Joint Ankylosis Of The Upper Arm Joint Diseases Joint Disease Arthropathy Associated With Infection
Factor V Deficiency	Parahemophilia Labile Factor Deficiency Proaccelerin Deficiency Owren Disease Owren Parahemophilia Quebec Platelet Disorder Deficiency, Labile Hereditary Hypoproaccelerinaemia Owren'S Disease Congenital Factor V Deficiency FA5D Factor 5 Deficiency Deficiency, Factor V
Factor Xiii Deficiency	Hereditary Factor Xiii Deficiency Disease Deficiency, Laki-Lorand Factor Congenital Factor Xiii Deficiency Fibrin Stabilizing Factor Deficiency Deficiency, Factor Xiii Factor Xiii Deficiency Disease Deficiency Of Factor Xiii Fibrin-Stabilizing Factor Deficiency Factor Xiii Deficiency, Congenital
Factor V And Factor Viii, Combined Deficiency Of, 2	Factor V And Factor Viii, Combined Deficiency Of F5F8D2 Combined Deficiency Of Factor V And Factor Viii F5f8d Factor 5 And Factor Viii, Combined Deficiency Of, 2 Fv And Fviii Combined Deficiency Factor V And Factor Viii Combined Deficiency 2 Mcfd2 Multiple Coagulation Factor Deficiency 2 Deficiency, Combined, Factor V And Factor Viii, Type 2
Thrombophilia Due To Activated Protein C Resistance	Activated Protein C Resistance Apc Resistance THPH2 Thrombophilia Due To Deficiency Of Activated Protein C Cofactor Proc Cofactor Deficiency Pccf Deficiency Thrombophilia V Thrombophilia, Susceptibility To, Due To Factor V Leiden Thrombophilia Due To Factor V Leiden Thrombophilia 2 Due To Activated Protein C Resistance Thrombophilia, Susceptibility To, Due To Activated Protein C Resistance
Compartment Syndrome	Compartment Syndromes Compartmental Syndrome
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Factor Vii Deficiency	Hypoproconvertinemia F7 Deficiency Congenital Proconvertin Deficiency Congenital Factor Vii Deficiency Factor 7 Deficiency Deficiency, Stable Proconvertin Deficiency Prothrombin Conversion Accelerator Deficiency Serum Prothrombin Conversion Accelerator Deficiency Proconvertin Deficiency, Congenital FA7D Stable Disease Deficiency, Factor Vii
Brachydactyly, Type D	Brachydactyly Type D BDD Stub Thumb Brachydactyly D
Thrombosis	Thrombosis Of Blood Vessel
Acquired Von Willebrand Syndrome	Acquired Von Willebrand Disease Willebrand Disease, Acquired Avws
Vitamin K Deficiency Bleeding	Vitamin K Deficiency Deficiency Of Vitamin K Vitamin K Vitamin K Deficiency Hemorrhagic Disease
Bernard-Soulier Syndrome	Giant Platelet Syndrome BSS Von Willebrand Factor Receptor Deficiency Bdplt1 Platelet Glycoprotein Ib Deficiency Bernard-Soulier Syndrome, Type A1 Bernard-Soulier Syndrome, Type B Bernard Soulier Syndrome Deficiency Of Platelet Glycoprotein 1b Hemorrhagiparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type C Bleeding Disorder, Platelet-Type, 1 Glycoprotein Ib, Platelet, Deficiency Of Giant Platelet Disorder, Isolated Giant Platelet Disease Macrothrombocytopenia, Familial Bernard-Soulier Type Bernard-Soulier Syndrome, Type C Bernard - Soulier Thrombopathy Hemorrhagic Dystrophic Thrombocytopenia Thrombopathy, Bernard-Soulier Platelet Glycoprotein 1b, Deficiency Of Hemorrhagioparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type A1 Bernard-Soulier Syndrome Type B Bleeding Disorder Platelet-Type 1 Gpd Macrothrombocytopenia, Familial, Bernard-Soulier Type
Glanzmann Thrombasthenia 1	Glanzmann Thrombasthenia Thrombasthenia Of Glanzmann And Naegeli Glanzmann'S Thrombasthenia Bdplt2 Platelet Glycoprotein Iib-Iiia Deficiency Deficiency Of Platelet Fibrinogen Receptor GT1 Gt Platelet Fibrinogen Receptor Deficiency Glycoprotein Complex Iib-Iiia Deficiency Deficiency Of Glycoprotein Complex Iib-Iiia Glycoprotein Iib/Iiia Defect Glanzmann Thrombasthenia, Type A Thrombasthenia Bleeding Disorder, Platelet-Type, 2 Gp Iib-Iiia Complex Deficiency Deficiency Of Gp Iib-Iiia Complex Platelet-Type Bleeding Disorder 2 Thrombocytasthenia Deficiency Of Gp 2b 3a Complex Diacyclothrombopathia 2b 3a Glanzmann Thrombasthenia Type A Platelet Fibrinogen Receptor, Deficiency Of Platelet Glycoprotein 2b 3a Deficiency Glanzmann Disease Glanzmann-Naegeli Disorder Hereditary Hemorrhagic Thrombasthenia Hereditary Thrombasthenia Bleeding Disorder Platelet-Type 2
Thrombophilia Due To Thrombin Defect	Venous Thromboembolism Venous Thrombosis Thrombophilia Due To Factor 2 Defect Thromboembolism THPH1 Thromboembolism, Susceptibility To Venous Thromboembolism, Susceptibility To Venous Thrombosis, Protection Against Prothrombin-Related Thrombophilia Hyperprothrombinemia Venous Thrombosis, Susceptibility To Thrombophilia 1 Due To Thrombin Defect F2-Related Thrombophilia Factor Ii-Related Thrombophilia Prothrombin 20210g>A Thrombophilia Prothrombin G20210a Thrombophilia Prothrombin Thrombophilia
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Afibrinogenemia, Congenital	Congenital Afibrinogenemia Afibrinogenemia Factor I Deficiency Familial Afibrinogenemia Hypofibrinogenemia, Congenital Fibrinogen Deficiency Afibrinogenemia Congenital CAFBN Congenital Hypofibrinogenemia Hypofibrinogenemia Complement Factor I Deficiency
Retinal Artery Occlusion	Retina Artery Narrowing Retinal Artery Spasm Spasm Of Ophthalmic Artery Retinal Spasm Vasospasm Of Retina
Intracranial Thrombosis	Cerebral Thrombosis Thrombosis Of Cerebral Veins Cerebral Arterial Thrombosis
Hepatic Veno-Occlusive Disease	Veno-Occlusive Disease Sinusoidal Obstruction Syndrome Hepatic Venoocclusive Disease Venoocclusive Disease Hepatic Vein Thrombosis Budd-Chiari Syndrome Hepatic Vein Occlusion Veno-Occlusive Disease Of The Liver
Childhood Angiosarcoma	Paediatric Angiosarcoma Paediatric Hemangiosarcoma Pediatric Angiosarcoma Pediatric Hemangiosarcoma
Thrombophlebitis	Phlebitis And Thrombophlebitis Of Superficial Vessels Of Lower Extremities Superficial Thrombophlebitis Of Leg Thrombophlebitis Of A Superficial Leg Vein Thrombophlebitis Of Superficial Veins Of Lower Extremity
Prothrombin Deficiency	Factor Ii Deficiency Hypoprothrombinemia Dysprothrombinemia Deficiency, Prothrombin Inherited Factor Ii Deficiency Hereditary Factor Ii Deficiency Disease
Blood Coagulation Disease	Blood Coagulation Disorders Coagulation Protein Disease Inherited Blood Coagulation Disease Postpartum Coagulation Defect Postpartum Coagulation Defect With Delivery Coagulation Protein Disorders Puerperal Coagulopathy
Pulmonary Embolism	Pulmonary Artery Embolism Pulmonary Embolus Pulmonary Emboli
Portal Vein Thrombosis	Phlebitis Of Portal Vein Deep Vein Thrombosis Of Portal Vein Portal Thrombosis Pvt - [Portal Vein Thrombosis] Portal Venous Thrombosis Portal Venous Embolism Portal Venous Obstruction Portal Venous Block Portal Vein Embolism Portal Vein Block Portal Obstruction Portal Embolism Portal Block Hepatic Portal Vein Obstruction Occlusion Of Hepatic Portal Vein Portal Vein Obstruction
Factor Xi Deficiency	Plasma Thromboplastin Antecedent Deficiency Rosenthal Syndrome Pta Deficiency Hemophilia C Rosenthal Factor Deficiency F11 Deficiency Congenital Factor Xi Deficiency Hereditary Factor Xi Deficiency Disease Haemophilia C Factor Xi Deficiency, Autosomal Dominant Rosenthal'S Disease Factor 11 Deficiency Factor Xi Factor Xi Deficiency, Autosomal Recessive Factor Xi Deficiency, Congenital FA11D Thromboplastin Antecedent Deficiency Pta - [Plasma Thromboplastin Antecedent] Deficiency Congenital Factor Xi Deficiency Disease Rosenthal Disease
Sneddon Syndrome	Livedo Reticularis And Cerebrovascular Accidents SNDNS Ehrmann-Sneddon Syndrome Livedo Racemosa-Cerebrovascular Accident Syndrome Livedo Reticularis-Cerebrovascular Accident Syndrome Sneddon'S Syndrome Idiopathic Livedo Reticularis With Systemic Involvement Cerebro-Vascular Lesions And Livedo Reticularis Livedo Racemosa And Cerebrovascular Accidents
Thrombotic Thrombocytopenic Purpura	Purpura, Thrombotic Thrombocytopenic Ttp Thrombotic Thrombocytopenic Purpura, Acquired Idiopathic Thrombotic Thrombocytopenic Purpura Moschcowitz Disease Moschcowitz'S Syndrome Moschowitz Syndrome Chronic Relapsing Thrombotic Thrombocytopenic Purpura Familial Thrombotic Thrombocytopenia Purpura Moschkowitz Disease Purpura Thrombotic Thrombocytopenic Familial Thrombotic Thrombocytopenic Purpura Microangiopathic Hemolytic Anemia Congenital Thrombotic Thrombocytopenic Purpura Autoimmune Thrombotic Thrombocytopenic Purpura Ttp - [Thrombotic Thrombocytopenic Purpura] Moschcowitz Syndrome
Thrombocytopenic Purpura, Autoimmune	Idiopathic Thrombocytopenic Purpura Autoimmune Thrombocytopenic Purpura Immune Thrombocytopenic Purpura Itp Idiopathic Purpura AITP Ideopath Thrombocytopenic Pur Primary Thrombocytopenic Purpura Werlhof'S Disease Thrombocytopenic Purpura Autoimmune Purpura Thrombocytopenic Idiopathic Purpura, Thrombocytopenic, Idiopathic Autoimmune Thrombocytopenia Thrombocytopenia Due To Platelet Alloimmunization Idiopathic Thrombocytopenia Idiopathic Thrombocytopenia Purpura Frank'S Essential Thrombocytopenia Itp - [Idiopathic Thrombocytopenia Purpura] Werlhof Disease Primary Autoimmune Thrombocytopenic Purpura Haemorrhagic Purpura Essential Thrombocytopenia Purpura Haemorrhagica
Homocystinuria	Cystathionine Beta Synthase Deficiency Homocysteinemia Cbs Deficiency Cystathionine Synthase Deficiency Cystathionine Beta-Synthase Deficiency Disease
Breast Hemangioma	Angioma Of The Breast Hemangioma Of Breast Haemangioma Of Breast
Hobnail Hemangioma
Pseudo-Von Willebrand Disease	Bdplt3 Von Willebrand Disease, Platelet-Type VWDP Platelet-Type Bleeding Disorder 3 Platelet Type-Von Willebrand Disease Pt-Vwd Von Willebrand Disease Platelet-Type Von Willebrand Disease, Platelet Type Pseudo Von Willebrand Disease Bleeding Disorder, Platelet-Type, 3 Pseudo-Von Willebrand Disease Type 2b Bleeding Disorder Platelet-Type 3 Pseudo-Vwd
Angiodysplasia	Angiodysplasia Of Colon Angiodysplasia Of Stomach And Duodenum With Hemorrhage Angiodysplasia Of Large Intestine Telangiectasia Of Colon Vascular Ectasia Of Colon Av - [Angiodysplasia Malformation Of Colon] Colon Angiodysplasia Colonic Angiodysplasia Vascular Ectasia Of Large Intestine
Synovial Angioma	Hemangioma Of Synovium Synovial Hemangioma
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Post-Thrombotic Syndrome	Postphlebitic Syndrome Postthrombotic Syndrome Postphlebetic Syndrome With Inflammation Postphlebetic Syndrome With Ulcer Postphlebetic Syndrome With Ulcer And Inflammation Venous Stress Disorder
Cerebral Arteritis	Brain Endarteritis Cerebral Or Cerebrospinal Endarteritis Brain Arteritis
Intracranial Sinus Thrombosis	Sinus Thrombosis, Intracranial
Alpha-2-Plasmin Inhibitor Deficiency	Plasmin Inhibitor Deficiency Antiplasmin Deficiency Antiplasmin Defiency Anti-Plasmin Deficiency, Congenital Antiplasmin Deficiency, Congenital Congenital Alpha2-Antiplasmin Deficiency APLID Congenital Alpha2 Antiplasmin Deficiency
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Factor X Deficiency	Stuart-Prower Factor Deficiency F10 Deficiency Congenital Stuart Factor Deficiency Factor X Deficiency, Congenital Congenital Factor X Deficiency Disease, Stuart-Prower Stuart Factor Deficiency, Congenital FA10D Factor 10 Deficiency Deficiency, Factor X Hereditary Factor X Deficiency Disease Deficiency Of Factor X Stuart Deficiency Disease Stuart Prower Deficiency Stuart-Prower Disease
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Pulmonary Artery Disease	Abnormality Of The Pulmonary Artery
Vein Disease	Disorder Of Vein
Diabetes Mellitus	Diabetes
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Brachydactyly
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P9964	Necitumumab	Inhibitor	99.90%	Unkown

Clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-107530	3F8	Inhibitor	/	Phase 2

Inhibitory Antibodies (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P99155	Zalutumumab		98.34%	Phase 3
HY-P99757	Nivatrotamab	Inhibitor	99.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (14)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-171036	GAPDH-IN-1	Inhibitor	98.10%	Unkown
HY-D2377	F8		98.25%	Unkown
HY-157252	CL4F8-6		99.80%	Unkown
HY-147844	F8-S43-S3	Inhibitor	/	Unkown
HY-147845	F8-S40	Inhibitor	/	Unkown
HY-157125	PI3Kα-IN-14		/	Unkown
HY-RS04117	E2F8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04646	F8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04647	F8A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17355	F8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22149	E2f8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23809	F8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W391641	F8BT		/	Unkown
HY-W440913	DSPE-PEG5000-Cy5		/	Unkown

Inhibitory Antibodies (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P990221	Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)	Inhibitor	≥95.0%	Unkown
HY-P990214	Anti-Mouse IL-3 Antibody (MP2-8F8)	Inhibitor	95.00%	Unkown
HY-P992000	F8-IL-4		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	F8	MGD	MGI:88383
Rattus norvegicus	F8	RGD	RGD:727845
Canis familiaris	F8	VGNC	VGNC:40553
Bos taurus	F8	VGNC	VGNC:28690
Macaca mulatta	F8	VGNC	VGNC:72467
Others	F8	NCBI