Traf2 - Tnf receptor-associated factor 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 311786

Summary

Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in negative regulation of glial cell apoptotic process; positive regulation of NF-kappaB transcription factor activity; and tumor necrosis factor-mediated signaling pathway. Located in cell cortex and membrane raft. Part of protein-containing complex. Orthologous to human TRAF2 (TNF Receptor associated factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Traf2 Products (1)

mRNA Protein Name
NM_001107815.2 NP_001101285.1 TNF receptor-associated factor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: Inferred from physical interaction
12050113 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12786973 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
10650002 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
12786973 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of glial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
9813034 RGD
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
10713108 RGD
involved in tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
10713108 RGD
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
12786973 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
12786973 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TNF receptor-associated factor 2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19696B Tauroursodeoxycholate dihydrate 99.96% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16591 Birinapant 99.70% Phase 2

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100830 NCB-0846 Inhibitor 99.61% Unkown
HY-134050 Apostatin-1 99.64% Unkown
HY-138779 ICCB-19 hydrochloride 99.25% Unkown
HY-124745 KY-05009 99.88% Unkown
HY-117469 Triptohypol C 96.56% Unkown
HY-153598 LD4172 98.32% Unkown
HY-145293 TNIK-IN-3 Inhibitor 99.79% Unkown
HY-124762 TNIK-IN-1 Inhibitor 99.25% Unkown
HY-156502 TINK-IN-1 Inhibitor 98.02% Unkown
HY-122805 PF-794 Inhibitor 99.19% Unkown
HY-156818 TNIK-IN-7 Inhibitor 99.65% Unkown
HY-100830A NCB-0970 Control 98.81% Unkown
HY-156817 TNIK-IN-6 Inhibitor 98.28% Unkown
HY-145292 TNIK-IN-2 Inhibitor 99.68% Unkown
HY-RS14197 TANK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14968 TRAF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174514 Human TNFRSF4 mRNA / Unkown
HY-RS16859 Traf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23300 Traf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Traf2 NCBI NCBI:7186