Ski - Ski proto-oncogene Gene

Also Known as c-ski; RGD1565591

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 313757

Summary

Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding activity; and histone deacetylase inhibitor activity. Predicted to be involved in several processes, including SMAD protein signal transduction; negative regulation of osteoblast differentiation; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within several processes, including animal organ development; face morphogenesis; and nervous system development. Predicted to be located in PML body; centrosome; and cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human SKI (SKI proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Ski Products (2)

mRNA Protein Name
XM_039111374.1 XP_038967302.1 ski oncogene isoform X2
XM_017593893.2 XP_017449382.2 ski oncogene isoform X1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cardiac muscle cell proliferation IEP
IEP: Inferred from expression pattern
2447874 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ski oncogene

  • Sloan-Kettering viral oncogene homolog

  • ski sarcoma viral oncogene homolog

  • v-ski avian sarcoma viral oncogene homolog

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10158 Bosutinib 99.97% Yes
HY-10158A Bosutinib hydrate Inhibitor 99.97% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-109082 Cevidoplenib Inhibitor 99.58% Phase 2

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13822 SKI II 99.25% Unkown
HY-18366A RU-SKI 43 hydrochloride Inhibitor 98.81% Unkown
HY-12892 SKI-178 99.29% Unkown
HY-162143 SKI-349 Inhibitor 99.48% Unkown
HY-19325 SKI2852 Inhibitor 98.89% Unkown
HY-115735 SKI-I 99.73% Unkown
HY-12895 SKI V 98.95% Unkown
HY-109082A Cevidoplenib dimesylate Inhibitor 98.96% Unkown
HY-N4308 Hexamethylquercetagetin Inhibitor 98.0% Unkown
HY-18366 RU-SKI 43 Inhibitor / Unkown
HY-10158S Bosutinib-d8 ≥99.0% Unkown
HY-117563 CAY10621 Inhibitor 99.3% Unkown
HY-10158S1 Bosutinib-13C,d3 / Unkown
HY-10158AR Bosutinib hydrate (Standard) Inhibitor / Unkown
HY-106588 Heptaplatin / Unkown
HY-161441 SIK-IN-2 Inhibitor / Unkown
HY-161442 SIK-IN-3 Inhibitor / Unkown
HY-RS12969 SKI Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-114206 SKI-73 / Unkown
HY-117982 SKI2496 / Unkown
HY-RS18593 Ski Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25078 Ski Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W714171 Propoxycarbazone sodium / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ski NCBI NCBI:6497