HOXA5 - homeobox A5 Gene

Also Known as HOX1; HOX1C; HOX1.3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3202

About HOXA5

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,141,052-27,143,681 (from NCBI)

This gene has 2 transcripts (splice variants), 195 orthologues and 42 paralogues. Biased expression in adrenal (RPKM 48.1), lung (RPKM 14.3) and 8 other tissues.

Summary

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]

HOXA5 Products (1)

mRNA	Protein	Name
NM_019102.4	NP_061975.2	homeobox protein Hox-A5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	8657138	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10879542	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10879542	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10879542	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15545268	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	17957028	GOA
involved in negative regulation of erythrocyte differentiation	IDA IDA: Inferred from direct assay	10397719	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	10879542	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	10875927	GOA
involved in positive regulation of myeloid cell differentiation	IDA IDA: Inferred from direct assay	10397719	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10879542	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	15545268	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXA5 Protein Structure

Homeobox

0
100
200
270 a.a.

Protein Preferred Names	Protein Names
homeobox protein Hox-A5	homeo box 1C

HOXA5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HOXA5	P20719	CTBP2	Homo sapiens	P56545-3	Validated Y2H	32296183
Intra	HOXA5	P20719	CTBP2	Homo sapiens	P56545-3	Y2H Prey Pooling	32296183
Intra	HOXA5	P20719	CTBP2	Homo sapiens	P56545-3	Y2H Array	32296183
Intra	HOXA5	P20719	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	HOXA5	P20719	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	HOXA5	P20719	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	HOXA5	P20719	PBX2	Homo sapiens	P40425	Validated Y2H	32296183
Intra	HOXA5	P20719	PBX2	Homo sapiens	P40425	Y2H Array	32296183
Intra	HOXA5	P20719	PBX2	Homo sapiens	P40425	Y2H Prey Pooling	32296183
Intra	HOXA5	P20719	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	HOXA5	P20719	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	HOXA5	P20719	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	HOXA5	P20719	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	HOXA5	P20719	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	HOXA5	P20719	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	HOXA5	P20719	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	HOXA5	P20719	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

HOXA5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83162	HOXA5 Antibody (YA2907)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Embryonal Carcinoma	Embryonal Neoplasm Embryonal Cancer Primary Extragonadal Embryonal Carcinoma Embryo Neoplasm Carcinoma Embryonal Cancer Embryonal Carcinoma, Embryonal Extragonadal Embryonal Carcinoma Cancer, Embryonal
Cardiomyopathy, Familial Hypertrophic, 20	Hypertrophic Cardiomyopathy 20 CMH20 Cardiomyopathy, Hypertrophic, 20 Cardiomyopathy Familial Hypertrophic 20 Cardiomyopathy, Familial Hypertrophic 20 Cardiomyopathy, Hypertrophic, Familial, Type 20
Mediastinal Gray Zone Lymphoma	Mediastinal B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Mediastinal Malignant Lymphoma	Lymphoma Of Mediastinum Mediastinal Lymphoma
Clubfoot	Congenital Talipes Equinovarus Congenital Clubfoot Congenital Equinovarus Equinovarus Deformity Of Foot Club Foot
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06300	HOXA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HOXA5	VGNC	VGNC:29913
Macaca mulatta	HOXA5	VGNC	VGNC:108414
Felis catus	HOXA5	VGNC	VGNC:102601
Canis familiaris	HOXA5	VGNC	VGNC:54769
Mus musculus	HOXA5	MGD	MGI:96177
Rattus norvegicus	HOXA5	RGD	RGD:620609
Others	HOXA5	NCBI