Rorc - RAR-related orphan receptor C Gene

Rattus norvegicus

Gene ID: 368158 | Gene type: protein coding

About Rorc

Primary_assembly 2: 182,009,286-182,034,907 forward strand.mRatBN7.2:CM026975.1

This gene has 4 transcripts (splice variants), 383 orthologues, 19 paralogues and is associated with 13 phenotypes. Biased expression in Thymus (RPKM 399.9), Liver (RPKM 124.) and 5 other tissues.

Summary

Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; oxysterol binding activity; and transcription coactivator binding activity. Involved in circadian rhythm. Predicted to be located in external side of plasma membrane and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 42. Orthologous to human RORC (RAR related orphan receptor C). [provided by Alliance of Genome Resources, Apr 2022]

Rorc Products(4)

mRNA	Protein	Name
XM_017591313.2	XP_017446802.1	nuclear receptor ROR-gamma isoform X2
XM_039103783.1	XP_038959711.1	nuclear receptor ROR-gamma isoform X3
XM_006232926.4	XP_006232988.2	nuclear receptor ROR-gamma isoform X1
XM_039103784.1	XP_038959712.1	nuclear receptor ROR-gamma isoform X4

Rorc Protein Structure

NR_DBD_ROR

NR_LBD_ROR_like

0
100
200
300
400
508 a.a.

Protein Preferred Names

Protein Names

nuclear receptor ROR-gamma

RAR-related orphan receptor gamma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112706	PF-06747711	Antagonist	99.86%	Unkown
HY-19775	GNE-6468		98.04%	Unkown
HY-19774	GNE-0946		98.09%	Unkown
HY-128353	ROR agonist-1	Antagonist	/	Unkown
HY-148237	JNJ-54119936		/	Unkown
HY-RS12132	RORC Human Pre-designed siRNA Set A		/	Unkown
HY-RS12133	Rorc Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS12134	Rorc Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rorc	NCBI	NCBI:6097

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