SHC4 - SHC adaptor protein 4 Gene

Also Known as RaLP; SHCD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 399694

About SHC4

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:48,823,741-48,963,919 (from NCBI)

This gene has 6 transcripts (splice variants), 179 orthologues and 3 paralogues. Biased expression in testis (RPKM 6.4), brain (RPKM 2.8) and 5 other tissues.

Summary

Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including apoptotic process; positive regulation of cell population proliferation; and stem cell differentiation. Predicted to be located in postsynaptic membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SHC4 Products (1)

mRNA Protein Name
NM_203349.4 NP_976224.3 SHC-transforming protein 4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24658140 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHC4 Protein Structure

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (192 - 347)

SH2

SH2: SH2 domain (527 - 597)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 630 a.a.
Protein Preferred Names Protein Names

SHC-transforming protein 4

  • SH2 domain protein C4

SHC4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SHC4 Q6S5L8 MET Homo sapiens P08581
FPS
24728074
Intra
SHC4 Q6S5L8 EGFR Homo sapiens P00533
Ub Reconstruction
24658140
Intra
SHC4 Q6S5L8 AR Homo sapiens P10275
FPS
24728074
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Obsessive-Compulsive Personality Disorder

  • Anankastic Personality Disorder

  • Obsessive-Compulsive Personality

  • Compulsive Personality Disorder

  • Ocpd

  • Obsessional Personality Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161464 Chlopynostat 98.36% Unkown
HY-RS12859 SHC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SHC4 MGD MGI:2655364
Rattus norvegicus SHC4 RGD RGD:1583644
Felis catus SHC4 VGNC VGNC:80847
Bos taurus SHC4 VGNC VGNC:106925
Macaca mulatta SHC4 VGNC VGNC:77249
Canis familiaris SHC4 VGNC VGNC:46142