2. Gene
  3. RET - ret proto-oncogene Gene

RET - ret proto-oncogene Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Canis lupus familiaris (sub-species: familiaris)
Gene ID: 403494 | Gene type: protein coding

About RET

Primary_assembly 28: 4,126,037-4,174,867 reverse strand.ROS_Cfam_1.0:CM025127.1

This gene has 3 transcripts (splice variants), 205 orthologues and 54 paralogues.

RET Products(1)

mRNA Protein Name
NM_001197099.1 NP_001184028.1 proto-oncogene tyrosine-protein kinase receptor Ret

RET Protein Structure

RET_CLD1

RET_CLD1: pfam17756 (30 - 156)

Cadherin

Cadherin: pfam00028 (175 - 264)

RET_CLD3

RET_CLD3: pfam17812 (268 - 382)

RET_CLD4

RET_CLD4: pfam17813 (407 - 509)

PTKc_RET

PTKc_RET: cd05045 (727 - 1016)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1119 a.a.
Protein Preferred Names Protein Names

proto-oncogene tyrosine-protein kinase receptor Ret

ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)

ret tyrosine kinase

Related Agents

Approval
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10981 Lenvatinib Inhibitor 99.84% Yes
HY-10331 Regorafenib Inhibitor 99.93% Yes
HY-114370 Selpercatinib Inhibitor 99.87% Yes
HY-112301 Pralsetinib Inhibitor 99.98% Yes
HY-10981A Lenvatinib mesylate Inhibitor 99.86% Yes
HY-13308 Regorafenib Hydrochloride Inhibitor 99.58% Yes
HY-10331A Regorafenib monohydrate Inhibitor 99.96% Yes
HY-10331B Regorafenib mesylate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-10206 Amuvatinib Inhibitor 99.47% Phase 2
HY-132846 Vepafestinib Inhibitor 98.84% Phase 2
HY-10206A Amuvatinib hydrochloride Inhibitor / Phase 2
HY-10032 PF 477736 Inhibitor 99.21% Phase 1
HY-100459 GSK3179106 Inhibitor 98.41% Phase 1
Pre-clinical Phase
Bioactive Molecules (60)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10410 TG101209 Inhibitor 99.22% Unkown
HY-15002 AST 487 Inhibitor 99.42% Unkown
HY-124401 BT-13 Agonist 99.59% Unkown
HY-18840 BBT594 Inhibitor 99.86% Unkown
HY-101963 AD80 Inhibitor 99.88% Unkown
HY-133551 WF-47-JS03 Inhibitor 99.63% Unkown
HY-15769 WHI-P180 Inhibitor 99.62% Unkown
HY-139590 Zeteletinib Inhibitor 99.06% Unkown
HY-112301A trans-Pralsetinib Inhibitor 96.07% Unkown
HY-145565 Enbezotinib Inhibitor 99.50% Unkown
HY-156135 NSC194598 Inhibitor ≥98.0% Unkown
HY-110193 SPP-86 Inhibitor 99.62% Unkown
HY-U00437 Pz-1 Inhibitor 99.92% Unkown
HY-136534 RET V804M-IN-1 Inhibitor 98.22% Unkown
HY-153175 BT44 Activator 99.08% Unkown
HY-10981S Lenvatinib-d4 Inhibitor 99.59% Unkown
HY-133553 RET-IN-3 Inhibitor 99.51% Unkown
HY-18507 AD57 Inhibitor 98.08% Unkown
HY-18317 JNJ-38158471 Inhibitor 97.02% Unkown
HY-34595 Pyrazoloadenine Inhibitor 99.98% Unkown
HY-139590A Zeteletinib hemiadipate Inhibitor / Unkown
HY-132193 RET-IN-4 Inhibitor / Unkown
HY-144422 RET-IN-15 Inhibitor / Unkown
HY-10981S1 Lenvatinib-d5 Inhibitor / Unkown
HY-145024 RET-IN-6 Inhibitor / Unkown
HY-117873 KBP-7018 Inhibitor / Unkown
HY-149539 PLM-101 Inhibitor / Unkown
HY-151987 RET-IN-20 Inhibitor / Unkown
HY-146710 RET-IN-16 Inhibitor / Unkown
HY-13342AS Apatinib-d8 free base 92.56% Unkown
HY-153941 RET-IN-24 Inhibitor / Unkown
HY-112950 RET-IN-1 Inhibitor / Unkown
HY-153676 RET-IN-23 Inhibitor / Unkown
HY-156113 RET-IN-25 Inhibitor / Unkown
HY-149413 FHND5071 Inhibitor / Unkown
HY-14979A ML786 dihydrochloride Inhibitor / Unkown
HY-143546 RET-IN-9 Inhibitor / Unkown
HY-151377 RET-IN-19 Inhibitor / Unkown
HY-156471 RET-IN-26 Inhibitor / Unkown
HY-146680 FLT3/ITD-IN-4 Inhibitor / Unkown
HY-144170 RET-IN-14 Inhibitor / Unkown
HY-120214 TAS05567 / Unkown
HY-144029 RET-IN-13 Inhibitor / Unkown
HY-141896 RET-IN-7 Inhibitor 98.00% Unkown
HY-147563 RET-IN-17 Inhibitor / Unkown
HY-149099 RET-IN-22 Inhibitor / Unkown
HY-143615 RET-IN-10 Inhibitor / Unkown
HY-151945 TRK II-IN-1 Inhibitor / Unkown
HY-144131 RET-IN-11 Inhibitor / Unkown
HY-148015 Enbezotinib (enantiomer) Inhibitor 99.72% Unkown
HY-18507A AD57 hydrochloride Inhibitor / Unkown
HY-149415 Multi-kinase-IN-5 Inhibitor / Unkown
HY-143545 RET-IN-8 Inhibitor / Unkown
HY-145023 RET-IN-5 Inhibitor / Unkown
HY-147564 RET-IN-18 Inhibitor / Unkown
HY-10331S1 Regorafenib-13C,d3 Inhibitor / Unkown
HY-15769A WHI-P180 hydrochloride Inhibitor / Unkown
HY-148742 RET-IN-21 Inhibitor / Unkown
HY-116116 Tafetinib Inhibitor / Unkown
HY-144030 RET-IN-12 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens RET NCBI NCBI:5979
Macaca fascicularis RET NCBI NCBI:102135879
Mus musculus RET NCBI NCBI:19713
Susscrofa domestica RET NCBI
Rattus norvegicus RET NCBI NCBI:24716
Macaca mulatta RET NCBI NCBI:703466