RET - ret proto-oncogene Gene
Species: Canis lupus familiaris (sub-species: familiaris)
Gene Type: protein coding
Gene ID: 403494
About RET
Primary_assembly 28: 4,126,037-4,174,867 reverse strand.ROS_Cfam_1.0:CM025127.1
This gene has 3 transcripts (splice variants), 205 orthologues and 54 paralogues.
RET Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001197099.1 | NP_001184028.1 | proto-oncogene tyrosine-protein kinase receptor Ret |
RET Protein Structure
RET_CLD1
RET_CLD1: pfam17756 (30 - 156)
Cadherin
Cadherin: pfam00028 (175 - 264)
RET_CLD3
RET_CLD3: pfam17812 (268 - 382)
RET_CLD4
RET_CLD4: pfam17813 (407 - 509)
PTKc_RET
PTKc_RET: cd05045 (727 - 1016)
- 0
- 200
- 400
- 600
- 800
- 1000
- 1119 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
proto-oncogene tyrosine-protein kinase receptor Ret |
|
Related Agents
- Approval
- Clinical Phase
- Pre-clinical Phase
Approval
Bioactive Molecules
(8)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-10981 | Lenvatinib | Inhibitor | 99.75% | Yes |
| HY-10331 | Regorafenib | Inhibitor | 99.97% | Yes |
| HY-10981A | Lenvatinib mesylate | Inhibitor | 99.91% | Yes |
| HY-114370 | Selpercatinib | Inhibitor | 99.83% | Yes |
| HY-112301 | Pralsetinib | Inhibitor | 99.98% | Yes |
| HY-10331A | Regorafenib monohydrate | Inhibitor | 99.94% | Yes |
| HY-13308 | Regorafenib Hydrochloride | Inhibitor | 99.58% | Yes |
| HY-10331B | Regorafenib mesylate | Inhibitor | / | Unkown |
Clinical Phase
Bioactive Molecules
(10)
| Cat. No. | Product Name |
Effect
|
Purity |
Phase
|
|---|---|---|---|---|
| HY-10206 | Amuvatinib | Inhibitor | 99.40% | Phase 2 |
| HY-132846 | Vepafestinib | Inhibitor | 98.61% | Phase 2 |
| HY-145565 | Enbezotinib | Inhibitor | 99.50% | Phase 2 |
| HY-149451 | SYHA1815 | Inhibitor | / | Phase 2 |
| HY-10032 | PF 477736 | Inhibitor | 99.04% | Phase 1 |
| HY-100459 | GSK3179106 | Inhibitor | 99.81% | Phase 1 |
| HY-139590 | Zeteletinib | Inhibitor | 98.31% | Phase 1 |
| HY-116116 | Tafetinib | Inhibitor | 96.20% | Phase 1 |
| HY-178061 | APS03118 | Inhibitor | 98.99% | Phase 1 |
| HY-149413 | FHND5071 | Inhibitor | / | Phase 1 |
Pre-clinical Phase
Bioactive Molecules
(125)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-15002 | AST 487 | Inhibitor | 98.90% | Unkown |
| HY-10410 | TG101209 | Inhibitor | 98.81% | Unkown |
| HY-101963 | AD80 | Inhibitor | 99.41% | Unkown |
| HY-18840 | BBT594 | Inhibitor | 99.93% | Unkown |
| HY-156135 | NSC194598 | Inhibitor | 98.90% | Unkown |
| HY-153175 | BT44 | Activator | 98.87% | Unkown |
| HY-162565 | CDD-2807 | Inhibitor | 99.52% | Unkown |
| HY-N10889 | Sominone | Activator | 99.96% | Unkown |
| HY-136534 | RET V804M-IN-1 | Inhibitor | 99.36% | Unkown |
| HY-13342AS | Apatinib-d8 free base | 92.5% | Unkown | |
| HY-P10044 | IGF1Rtide | 99.53% | Unkown | |
| HY-18507 | AD57 | Inhibitor | 98.27% | Unkown |
| HY-110193 | SPP-86 | Inhibitor | 99.87% | Unkown |
| HY-101246 | RPI-1 | Inhibitor | 98.47% | Unkown |
| HY-10981S | Lenvatinib-d4 | Inhibitor | 99.59% | Unkown |
| HY-112301A | trans-Pralsetinib | Inhibitor | 98.06% | Unkown |
| HY-15769 | WHI-P180 | Inhibitor | 99.84% | Unkown |
| HY-U00437 | Pz-1 | Inhibitor | 99.90% | Unkown |
| HY-133551 | WF-47-JS03 | Inhibitor | 99.63% | Unkown |
| HY-148742 | RET-IN-21 | Inhibitor | 97.02% | Unkown |
| HY-133553 | RET-IN-3 | Inhibitor | 99.51% | Unkown |
| HY-18317 | JNJ-38158471 | Inhibitor | 97.02% | Unkown |
| HY-34595 | Pyrazoloadenine | Inhibitor | 99.98% | Unkown |
| HY-10331S | Regorafenib-d3 | Inhibitor | 98.0% | Unkown |
| HY-10206A | Amuvatinib hydrochloride | Inhibitor | / | Unkown |
| HY-132193 | RET-IN-4 | Inhibitor | / | Unkown |
| HY-139590A | Zeteletinib hemiadipate | Inhibitor | / | Unkown |
| HY-151987 | RET-IN-20 | Inhibitor | / | Unkown |
| HY-14979A | ML786 dihydrochloride | Inhibitor | / | Unkown |
| HY-117873A | KBP-7018 hydrochloride | Inhibitor | / | Unkown |
| HY-147563 | RET-IN-17 | Inhibitor | / | Unkown |
| HY-170856 | RET ligand-4 | Ligand | / | Unkown |
| HY-E70771 | RET L730I Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-143545 | RET-IN-8 | Inhibitor | / | Unkown |
| HY-E70767 | RET G691S Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-170373 | RET ligand-1 | Inhibitor | / | Unkown |
| HY-144422 | RET-IN-15 | Inhibitor | / | Unkown |
| HY-178964 | PROTAC RET Degrader 1 | Degrader | / | Unkown |
| HY-170926 | CQ1373 | Inhibitor | / | Unkown |
| HY-180551 | ZW-6-052 | Degrader | / | Unkown |
| HY-E70769 | RET G810R Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-183783 | PROTAC RET Degrader 2 | Degrader | / | Unkown |
| HY-170019 | RET-IN-28 | Inhibitor | / | Unkown |
| HY-144131 | RET-IN-11 | Inhibitor | / | Unkown |
| HY-159824 | Soxataltinib | Inhibitor | / | Unkown |
| HY-170809 | RET-IN-29 | Inhibitor | / | Unkown |
| HY-164413 | CLM3 | Inhibitor | / | Unkown |
| HY-176937 | HSN608 | Inhibitor | / | Unkown |
| HY-10981S2 | Lenvatinib-15N,d4 | Inhibitor | 98.01% | Unkown |
| HY-14979 | ML786 | Inhibitor | / | Unkown |
| HY-168867 | RD-23 | Degrader | / | Unkown |
| HY-180550 | ZW-18-116 | Degrader | / | Unkown |
| HY-156471 | RET-IN-26 | Inhibitor | / | Unkown |
| HY-E70774 | RET R749T Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-151945 | TRK II-IN-1 | Inhibitor | / | Unkown |
| HY-168105 | RET-IN-27 | Inhibitor | / | Unkown |
| HY-E70859 | RET L790F Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-171146 | HSN748 | Inhibitor | / | Unkown |
| HY-178786 | RET-IN-31 | Inhibitor | / | Unkown |
| HY-E70776 | RET S891A Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-176885A | CDD-2212 | Inhibitor | / | Unkown |
| HY-E70768 | RET G810C Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-E70770 | RET G810S Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-184396 | GR2-128 | Inhibitor | / | Unkown |
| HY-170855A | YW-N-7 TFA | Degrader | / | Unkown |
| HY-183729 | RET-IN-34 | Inhibitor | / | Unkown |
| HY-143615 | RET-IN-10 | Inhibitor | / | Unkown |
| HY-182741 | RET-IN-32 | Inhibitor | / | Unkown |
| HY-148015 | Enbezotinib (enantiomer) | Inhibitor | 99.72% | Unkown |
| HY-145024 | RET-IN-6 | Inhibitor | / | Unkown |
| HY-183931 | NPA101.3 | Inhibitor | / | Unkown |
| HY-161775 | RET/TRKA-IN-1 | Inhibitor | / | Unkown |
| HY-181895 | RET degrader-1 | Degrader | / | Unkown |
| HY-176885 | CDD-2211 | Inhibitor | / | Unkown |
| HY-143546 | RET-IN-9 | Inhibitor | / | Unkown |
| HY-149099 | RET-IN-22 | Inhibitor | / | Unkown |
| HY-E70781 | RET Y806H Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-172952 | LRRK2-IN-17 | Inhibitor | / | Unkown |
| HY-18507A | AD57 hydrochloride | Inhibitor | / | Unkown |
| HY-174245 | RET-IN-30 | Inhibitor | / | Unkown |
| HY-10331S1 | Regorafenib-13C,d3 | Inhibitor | / | Unkown |
| HY-153676 | RET-IN-23 | Inhibitor | / | Unkown |
| HY-E70789 | BCR-RET Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-181918 | PLM-101-C3-NHBoc | / | Unkown | |
| HY-183684 | RET-IN-33 | Inhibitor | / | Unkown |
| HY-182354 | VEGFR2-IN-84 | Inhibitor | / | Unkown |
| HY-170852 | QZ2135 | Degrader | / | Unkown |
| HY-149539 | PLM-101 | Inhibitor | / | Unkown |
| HY-147564 | RET-IN-18 | Inhibitor | / | Unkown |
| HY-112950 | RET-IN-1 | Inhibitor | / | Unkown |
| HY-E70772 | RET L730M Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-120214 | TAS05567 | / | Unkown | |
| HY-141896 | RET-IN-7 | Inhibitor | 98.00% | Unkown |
| HY-10981S1 | Lenvatinib-d5 | Inhibitor | / | Unkown |
| HY-149415 | Multi-kinase-IN-5 | Inhibitor | / | Unkown |
| HY-E70779 | RET V804M Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-E70775 | RET R813Q Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-E70777 | RET V804E Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-168868 | RET ligand-2 | Inhibitor | / | Unkown |
| HY-114588 | Tafetinib analogue 1 | Inhibitor | / | Unkown |
| HY-115541 | BRD4-IN-41 | / | Unkown | |
| HY-146710 | RET-IN-16 | Inhibitor | / | Unkown |
| HY-153941 | RET-IN-24 | Inhibitor | / | Unkown |
| HY-151377 | RET-IN-19 | Inhibitor | / | Unkown |
| HY-E70766 | RET E762Q Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-144029 | RET-IN-13 | Inhibitor | / | Unkown |
| HY-179308 | RET ligand-5 | Degrader | / | Unkown |
| HY-176884 | CDD-2110 | Inhibitor | / | Unkown |
| HY-170854 | RET Ligand-Linker Conjugate-1 | Ligand | / | Unkown |
| HY-156113 | RET-IN-25 | Inhibitor | / | Unkown |
| HY-144170 | RET-IN-14 | Inhibitor | / | Unkown |
| HY-145023 | RET-IN-5 | Inhibitor | / | Unkown |
| HY-E70778 | RET V804L Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-170853 | RET ligand-3 | Degrader | / | Unkown |
| HY-E70780 | RET Y791F Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-174993 | FHND5071 (1H) | Inhibitor | / | Unkown |
| HY-E70773 | RET M918T Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-146680 | FLT3/ITD-IN-4 | Inhibitor | / | Unkown |
| HY-164549 | XMD15-44 | Inhibitor | / | Unkown |
| HY-18817 | AFG210 | Inhibitor | / | Unkown |
| HY-W759629 | Selpercatinib-d3 | Inhibitor | / | Unkown |
| HY-117873 | KBP-7018 | Inhibitor | / | Unkown |
| HY-15769A | WHI-P180 hydrochloride | Inhibitor | / | Unkown |
| HY-164482 | HG-6-63-01 | Inhibitor | / | Unkown |
| HY-144030 | RET-IN-12 | Inhibitor | / | Unkown |
Inhibitory Antibodies
(3)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-P99828 | Cofetuzumab | Inhibitor | 99.31% | Unkown |
| HY-P992232 | Anti-GFRA4 Antibody (scFv) | Inhibitor | / | Unkown |
| HY-P992009 | Anti-GFRA4 Antibody | Inhibitor | / | Unkown |
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