MDK - midkine Gene

Also Known as MK; ARAP; NEGF2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4192

About MDK

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,380,784-46,383,837 (from NCBI)

This gene has 12 transcripts (splice variants), 247 orthologues and 1 paralogue. Broad expression in ovary (RPKM 88.5), endometrium (RPKM 55.5) and 14 other tissues.

Summary

This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

MDK Products (6)

mRNA Protein Name
NM_001012333.3 NP_001012333.1 midkine isoform a precursor
NM_001012334.2 NP_001012334.1 midkine isoform a precursor
NM_001270550.1 NP_001257479.1 midkine isoform a precursor
NM_001270551.3 NP_001257480.1 midkine isoform a precursor
NM_001270552.3 NP_001257481.1 midkine isoform b precursor
NM_002391.6 NP_002382.1 midkine isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables heparan sulfate binding IDA
IDA: Inferred from direct assay
12084985 GOA
enables heparin binding IDA
IDA: Inferred from direct assay
9384573 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10212223 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
18469519 GOA
involved in leukocyte chemotaxis involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
10683378 GOA
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19060126 GOA
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
12573468 GOA
involved in negative regulation of regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
22323540 GOA
involved in positive regulation of blood vessel branching IMP
IMP: Inferred from mutant phenotype
19060126 GOA
involved in positive regulation of cell adhesion IDA
IDA: Inferred from direct assay
12084985 GOA
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
15466886 GOA
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
18469519 GOA
involved in positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
22323540 GOA
involved in positive regulation of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
22323540 GOA
involved in positive regulation of keratinocyte proliferation IDA
IDA: Inferred from direct assay
18469519 GOA
involved in positive regulation of leukocyte cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
24458438 GOA
involved in positive regulation of macrophage chemotaxis IMP
IMP: Inferred from mutant phenotype
10683378 GOA
involved in positive regulation of neuron migration IMP
IMP: Inferred from mutant phenotype
10212223 GOA
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
12084985 GOA
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
15466886 GOA
involved in positive regulation of oligodendrocyte differentiation IDA
IDA: Inferred from direct assay
27445335 GOA
involved in positive regulation of smooth muscle cell chemotaxis IMP
IMP: Inferred from mutant phenotype
10683378 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MDK Protein Structure

PTN_MK_N

PTN_MK_N: PTN/MK heparin-binding protein family, N-terminal domain (24 - 80)

PTN_MK_C

PTN_MK_C: PTN/MK heparin-binding protein family, C-terminal domain (81 - 143)

  • 0
  • 100
  • 143 a.a.
Protein Preferred Names Protein Names

midkine

  • amphiregulin-associated protein

MDK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MDK P21741 TMED8 Homo sapiens Q6PL24
Validated Y2H
32296183
Intra
MDK P21741 MIEF2 Homo sapiens Q96C03-3
Validated Y2H
32296183
Intra
MDK P21741 JOSD2 Homo sapiens Q8TAC2
Validated Y2H
32296183
Intra
MDK P21741 RBFA Homo sapiens Q8N0V3
Validated Y2H
32296183
Intra
MDK P21741 AP1M1 Homo sapiens Q9BXS5
Validated Y2H
32296183
Intra
MDK P21741 TCEA2 Homo sapiens Q15560
Validated Y2H
32296183
Intra
MDK P21741 NFU1 Homo sapiens Q9UMS0
Validated Y2H
32296183
Intra
MDK P21741 PBX3 Homo sapiens Q96AL5
Validated Y2H
32296183
Intra
MDK P21741 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
MDK P21741 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
MDK P21741 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
MDK P21741 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MDK Proteins

Cat. No. Product Name Accession Purity
HY-P73295 MDK/Midkine Protein, Human (sf9) P21741-1 (V21-D143) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700138AF Animal-Free MDK Protein, Human (His) P21741-1 (V21-D143) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700791 MDK/Midkine Protein, Human (His-Avi) P21741-1 (V21-D143) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P701024 MDK/Midkine Protein, Human (Biotinylated, His-Avi) P21741-1 (V21-D143) ≥ 95%, as determined by reducing SDS-PAGE.

MDK Antibodies

Cat. No. Product Name Application Reactivity
HY-P81837 Midkine Antibody (YA1582) WB, IP Human
HY-P81837A Midkine Antibody (YA1582)(PBS only) WB, IP Human

Related Diseases

Diseases Alias
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110171 iMDK Inhibitor 99.35% Unkown
HY-110171A iMDK quarterhydrate Inhibitor 99.37% Unkown
HY-18633 MDK83190 Activator 98.61% Unkown
HY-178164 HBS-101 99.59% Unkown
HY-RS08262 MDK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119467 MDK0734 / Unkown
HY-RS16729 Mdk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23165 Mdk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MDK RGD RGD:69073
Mus musculus MDK MGD MGI:96949
Felis catus MDK VGNC VGNC:68222
Bos taurus MDK VGNC VGNC:49556
Others MDK NCBI