Fut8 - fucosyltransferase 8 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53618

Summary

Enables alpha-(1->6)-fucosyltransferase activity. Acts upstream of or within several processes, including N-glycan fucosylation; N-glycan processing; and cell surface receptor signaling pathway. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Is expressed in telencephalon. Used to study pulmonary emphysema. Orthologous to human FUT8 (fucosyltransferase 8). [provided by Alliance of Genome Resources, Apr 2022]

Fut8 Products (4)

mRNA Protein Name
NM_001252614.1 NP_001239543.1 alpha-(1,6)-fucosyltransferase isoform 1
NM_001252615.1 NP_001239544.1 alpha-(1,6)-fucosyltransferase isoform 2
NM_001252616.1 NP_001239545.1 alpha-(1,6)-fucosyltransferase isoform 3
NM_016893.5 NP_058589.2 alpha-(1,6)-fucosyltransferase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables alpha-(1->6)-fucosyltransferase activity IMP
IMP: Inferred from mutant phenotype
16236725 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within N-glycan fucosylation IMP
IMP: Inferred from mutant phenotype
24619415 MGI
acts upstream of or within N-glycan processing IMP
IMP: Inferred from mutant phenotype
24619415 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
17043354 MGI
acts upstream of or within fibroblast migration IMP
IMP: Inferred from mutant phenotype
17043354 MGI
acts upstream of or within integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
17043354 MGI
acts upstream of or within receptor metabolic process IMP
IMP: Inferred from mutant phenotype
16236725 MGI
acts upstream of or within regulation of cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
24619415 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24619415 MGI
acts upstream of or within respiratory gaseous exchange by respiratory system IMP
IMP: Inferred from mutant phenotype
16236725 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16236725 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-(1,6)-fucosyltransferase

  • GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase

  • GDP-fucose--glycoprotein fucosyltransferase

  • alpha1-6FucT

  • glycoprotein 6-alpha-L-fucosyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155747 FDW028 Inhibitor 99.51% Unkown
HY-E70157 Fucosyltransferase 8 / Unkown
HY-RS05159 FUT8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-170541 FUT8-IN-1 Inhibitor / Unkown
HY-181989 CAIF Inhibitor / Unkown
HY-RS17190 Fut8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23641 Fut8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99113A Inebilizumab (FUT8-KO) 99.84% Unkown
HY-P99010A Bemarituzumab (FUT8-KO) Inhibitor 99.74% Unkown
HY-P9980A Belantamab (FUT8-KO) 98.10% Unkown
HY-P9977A Amivantamab (FUT8-KO) Inhibitor 98% Unkown
HY-P99653A Ianalumab (FUT8-KO) Inhibitor 99.85% Unkown
HY-P99406A Petosemtamab (FUT8-KO) Degrader 99% Unkown
HY-P991942A Lanerkitug (FUT8-KO) Inhibitor 98.85% Unkown
HY-P991481A S-531011 (FUT8-KO) Inhibitor 99.10% Unkown
HY-P99226A Daxdilimab (FUT8-KO) Inhibitor 97% Unkown
HY-P990026A Ulviprubart (FUT8-KO) Inhibitor / Unkown
HY-P99014A Cusatuzumab (FUT8-KO) Inhibitor / Unkown
HY-P990755A Pamvatamig (FUT8-KO) Inhibitor / Unkown
HY-P991092A IBI-334 (FUT8-KO) Inhibitor / Unkown
HY-P991135A Enzelkitug (FUT8-KO) Inhibitor / Unkown
HY-P991514A MIL62 (FUT8-KO) Inhibitor / Unkown
HY-P991892A IT1208 (FUT8-KO) Inhibitor / Unkown
HY-P991944A ZL-1218 (FUT8-KO) Inhibitor / Unkown
HY-P992005A DS-1055a (FUT8-KO) Inhibitor / Unkown
HY-P99295A Imgatuzumab (FUT8-KO) Inhibitor / Unkown
HY-P99434A Amlitelimab (FUT8-KO) Inhibitor / Unkown
HY-P9991A Osemitamab (FUT8-KO) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fut8 NCBI NCBI:2530